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Initial acute in vivo performance of the Cleveland Clinic PediPump left ventricular assist device.
ASAIO J. 2007 Nov-Dec; 53(6):766-70.AJ

Abstract

The PediPump is a small ventricular assist device (VAD) with a hydraulic output range designed to support children from newborns to adolescents. The present report describes our initial evaluation of the PediPump as a left VAD in an acute sheep model. The PediPump was implanted in two sheep (50.8 and 62.7 kg). Pump speed was adjusted to achieve a flow of 2 L/min with the naturally occurring preload and afterload conditions to evaluate pump performance under a steady hemodynamic state for 4 hours. Upon completion, pump performance was evaluated under various blood pressure and heart rate conditions. During steady-state evaluations, the ascending aortic flow and pump speed varied slightly depending on systemic arterial pressure variations. During the hemodynamic manipulation studies, flows ranged between 0.5 and 3.2 L/min with pump speeds of 5,200-16,200 rpm and motor current of 0.06-0.75 A. The PediPump demonstrated good initial hemodynamic performance for use as an implantable left VAD. However, some depositions were detected at the time of explanation, mainly at the rear of the pump. We are continuing with further acute studies to evaluate pump performance in anticipation of beginning chronic studies to evaluate long-term biocompatibility.

Authors+Show Affiliations

Saeed D
Department of Biomedical Engineering, Lerner Research Institute, OH, USA.
Weber S
No affiliation info available
Ootaki Y
No affiliation info available
Mielke N
No affiliation info available
Ootaki C
No affiliation info available
Akiyama M
No affiliation info available
Horai T
No affiliation info available
Catanese J
No affiliation info available
Fumoto H
No affiliation info available
Hideyuki F
No affiliation info available
Dessoffy R
No affiliation info available
Dudzinski DT
No affiliation info available
Gu L
No affiliation info available
Casas F
No affiliation info available
Smith WA
No affiliation info available
Fukamachi K
No affiliation info available
Duncan BW
No affiliation info available

MeSH

AnimalsBiomedical EngineeringBlood Chemical AnalysisBlood PressureHeart RateHeart-Assist DevicesHemodynamicsHemoglobinsHemolysisMagneticsMaleNitroprussidePhenylephrineProsthesis DesignProsthesis ImplantationRotationSheepTime FactorsVasoconstrictor AgentsVasodilator AgentsVentricular Function, Left

Pub Type(s)

Evaluation Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18043163

Citation

Saeed, Diyar, et al. "Initial Acute in Vivo Performance of the Cleveland Clinic PediPump Left Ventricular Assist Device." ASAIO Journal (American Society for Artificial Internal Organs : 1992), vol. 53, no. 6, 2007, pp. 766-70.
Saeed D, Weber S, Ootaki Y, et al. Initial acute in vivo performance of the Cleveland Clinic PediPump left ventricular assist device. ASAIO J. 2007;53(6):766-70.
Saeed, D., Weber, S., Ootaki, Y., Mielke, N., Ootaki, C., Akiyama, M., Horai, T., Catanese, J., Fumoto, H., Hideyuki, F., Dessoffy, R., Dudzinski, D. T., Gu, L., Casas, F., Smith, W. A., Fukamachi, K., & Duncan, B. W. (2007). Initial acute in vivo performance of the Cleveland Clinic PediPump left ventricular assist device. ASAIO Journal (American Society for Artificial Internal Organs : 1992), 53(6), 766-70.
Saeed D, et al. Initial Acute in Vivo Performance of the Cleveland Clinic PediPump Left Ventricular Assist Device. ASAIO J. 2007 Nov-Dec;53(6):766-70. PubMed PMID: 18043163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Initial acute in vivo performance of the Cleveland Clinic PediPump left ventricular assist device. AU - Saeed,Diyar, AU - Weber,Stephan, AU - Ootaki,Yoshio, AU - Mielke,Nicole, AU - Ootaki,Chiyo, AU - Akiyama,Masatoshi, AU - Horai,Tetsuya, AU - Catanese,Jacquelyn, AU - Fumoto,Hideyuki, AU - Hideyuki,Fumoto, AU - Dessoffy,Raymond, AU - Dudzinski,David T, AU - Gu,Lei, AU - Casas,Fernando, AU - Smith,William A, AU - Fukamachi,Kiyotaka, AU - Duncan,Brian W, PY - 2007/11/29/pubmed PY - 2008/1/8/medline PY - 2007/11/29/entrez SP - 766 EP - 70 JF - ASAIO journal (American Society for Artificial Internal Organs : 1992) JO - ASAIO J VL - 53 IS - 6 N2 - The PediPump is a small ventricular assist device (VAD) with a hydraulic output range designed to support children from newborns to adolescents. The present report describes our initial evaluation of the PediPump as a left VAD in an acute sheep model. The PediPump was implanted in two sheep (50.8 and 62.7 kg). Pump speed was adjusted to achieve a flow of 2 L/min with the naturally occurring preload and afterload conditions to evaluate pump performance under a steady hemodynamic state for 4 hours. Upon completion, pump performance was evaluated under various blood pressure and heart rate conditions. During steady-state evaluations, the ascending aortic flow and pump speed varied slightly depending on systemic arterial pressure variations. During the hemodynamic manipulation studies, flows ranged between 0.5 and 3.2 L/min with pump speeds of 5,200-16,200 rpm and motor current of 0.06-0.75 A. The PediPump demonstrated good initial hemodynamic performance for use as an implantable left VAD. However, some depositions were detected at the time of explanation, mainly at the rear of the pump. We are continuing with further acute studies to evaluate pump performance in anticipation of beginning chronic studies to evaluate long-term biocompatibility. SN - 1538-943X UR - https://www.unboundmedicine.com/medline/citation/18043163/Initial_acute_in_vivo_performance_of_the_Cleveland_Clinic_PediPump_left_ventricular_assist_device_ DB - PRIME DP - Unbound Medicine ER -