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A case series of contact lens-associated Fusarium keratitis in Hong Kong.
Cornea 2007; 26(10):1205-9C

Abstract

PURPOSE

To report the clinical features and management outcomes of a cluster of Fusarium keratitis in patients that used the Bausch & Lomb ReNu MostureLoc contact lens solution.

METHODS

Retrospective case series.

RESULTS

In a 1-year period starting from June 2005, we treated 12 patients with unilateral Fusarium keratitis in our tertiary care center. All patients were contact lens users that used ReNu MostureLoc contact lens solution and had no other specific predisposing conditions. Microbiological examination yielded growth of Fusarium spp. in 7 patients from corneal scrapings at presentation and from 3 patients in subsequent corneal specimens. For 2 other patients, fungi were not detected from corneal scrapings, but Fusarium spp. were isolated from their contact lenses. The infections were treated with topical natamycin and amphotericin B eye drops and with systemic itraconazole in 8 patients. The infection resolved with medical treatment in 8 eyes, a conjunctival flap in 1 eye, and a therapeutic corneal graft in 1 eye. Two eyes required tectonic corneal grafts for perforation. Two of the 3 corneal grafts failed because of graft rejection. Final visual acuities ranged from count fingers to 1.0.

CONCLUSIONS

This cluster of Fusarium keratitis seems to be related to the use of the ReNu MoistureLoc contact lens solution. The cure rate with medical therapy was 66%. However, corneal scarring limited visual recovery. This episode highlights the need for clinical vigilance when dealing with corneal infiltrates in contact lens users.

Authors+Show Affiliations

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 3/F Hong Kong Eye Hospital, Kowloon, Hong Kong Special Administrative Region, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18043177

Citation

Rao, Srinivas K., et al. "A Case Series of Contact Lens-associated Fusarium Keratitis in Hong Kong." Cornea, vol. 26, no. 10, 2007, pp. 1205-9.
Rao SK, Lam PT, Li EY, et al. A case series of contact lens-associated Fusarium keratitis in Hong Kong. Cornea. 2007;26(10):1205-9.
Rao, S. K., Lam, P. T., Li, E. Y., Yuen, H. K., & Lam, D. S. (2007). A case series of contact lens-associated Fusarium keratitis in Hong Kong. Cornea, 26(10), pp. 1205-9.
Rao SK, et al. A Case Series of Contact Lens-associated Fusarium Keratitis in Hong Kong. Cornea. 2007;26(10):1205-9. PubMed PMID: 18043177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case series of contact lens-associated Fusarium keratitis in Hong Kong. AU - Rao,Srinivas K, AU - Lam,Philip T H, AU - Li,Emmy Y M, AU - Yuen,Hunter K L, AU - Lam,Dennis S C, PY - 2007/11/29/pubmed PY - 2008/3/5/medline PY - 2007/11/29/entrez SP - 1205 EP - 9 JF - Cornea JO - Cornea VL - 26 IS - 10 N2 - PURPOSE: To report the clinical features and management outcomes of a cluster of Fusarium keratitis in patients that used the Bausch & Lomb ReNu MostureLoc contact lens solution. METHODS: Retrospective case series. RESULTS: In a 1-year period starting from June 2005, we treated 12 patients with unilateral Fusarium keratitis in our tertiary care center. All patients were contact lens users that used ReNu MostureLoc contact lens solution and had no other specific predisposing conditions. Microbiological examination yielded growth of Fusarium spp. in 7 patients from corneal scrapings at presentation and from 3 patients in subsequent corneal specimens. For 2 other patients, fungi were not detected from corneal scrapings, but Fusarium spp. were isolated from their contact lenses. The infections were treated with topical natamycin and amphotericin B eye drops and with systemic itraconazole in 8 patients. The infection resolved with medical treatment in 8 eyes, a conjunctival flap in 1 eye, and a therapeutic corneal graft in 1 eye. Two eyes required tectonic corneal grafts for perforation. Two of the 3 corneal grafts failed because of graft rejection. Final visual acuities ranged from count fingers to 1.0. CONCLUSIONS: This cluster of Fusarium keratitis seems to be related to the use of the ReNu MoistureLoc contact lens solution. The cure rate with medical therapy was 66%. However, corneal scarring limited visual recovery. This episode highlights the need for clinical vigilance when dealing with corneal infiltrates in contact lens users. SN - 0277-3740 UR - https://www.unboundmedicine.com/medline/citation/18043177/A_case_series_of_contact_lens_associated_Fusarium_keratitis_in_Hong_Kong_ L2 - http://dx.doi.org/10.1097/ICO.0b013e31813e32a6 DB - PRIME DP - Unbound Medicine ER -