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Abnormal motor cortex excitability in congenital stroke.
Pediatr Res. 2008 Jan; 63(1):84-8.PR

Abstract

The aim of the present study was to investigate corticospinal and intracortical excitability in patients with congenital stroke. In adults, stroke sequelae reduce corticospinal excitability, as indicated by an elevated threshold for motor evoked potentials (MEP), and increase intracortical excitability, as indicated by reduced intracortical inhibition. Ten patients with pre- or perinatally acquired, unilateral cortico-subcortical infarctions in the middle cerebral artery territory were studied with single pulse transcranial magnetic stimulation (TMS) to measure motor threshold (MT) and with paired pulse TMS to study short interval intracortical inhibition (SICI) and intracortical facilitation (ICF). Eight healthy, age-matched subjects served as controls. MT over the affected hemisphere of patients compared with the dominant hemisphere of controls was significantly elevated, reflecting reduced corticospinal excitability, and SICI was significantly reduced, reflecting increased intracortical excitability. No such differences were found for ICF. Findings in patients with congenital stroke were comparable with adulthood stroke. Thus, similar assumptions can be made: reduced corticospinal excitability is probably a consequence of neuronal damage. Reduced intracortical inhibition might represent deficient inhibitory cortical properties or might reflect a compensational mechanism, dispositioning for use-dependent plasticity.

Authors+Show Affiliations

Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauners' Children's Hospital of the University of Munich, 80337 Munich, Germany. steffen.berweck@med.uni-muenchen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18043504

Citation

Berweck, Steffen, et al. "Abnormal Motor Cortex Excitability in Congenital Stroke." Pediatric Research, vol. 63, no. 1, 2008, pp. 84-8.
Berweck S, Walther M, Brodbeck V, et al. Abnormal motor cortex excitability in congenital stroke. Pediatr Res. 2008;63(1):84-8.
Berweck, S., Walther, M., Brodbeck, V., Wagner, N., Koerte, I., Henschel, V., Juenger, H., Staudt, M., & Mall, V. (2008). Abnormal motor cortex excitability in congenital stroke. Pediatric Research, 63(1), 84-8.
Berweck S, et al. Abnormal Motor Cortex Excitability in Congenital Stroke. Pediatr Res. 2008;63(1):84-8. PubMed PMID: 18043504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abnormal motor cortex excitability in congenital stroke. AU - Berweck,Steffen, AU - Walther,Michael, AU - Brodbeck,Verena, AU - Wagner,Nina, AU - Koerte,Inga, AU - Henschel,Volkmar, AU - Juenger,Hendrik, AU - Staudt,Martin, AU - Mall,Volker, PY - 2007/11/29/pubmed PY - 2008/2/8/medline PY - 2007/11/29/entrez SP - 84 EP - 8 JF - Pediatric research JO - Pediatr Res VL - 63 IS - 1 N2 - The aim of the present study was to investigate corticospinal and intracortical excitability in patients with congenital stroke. In adults, stroke sequelae reduce corticospinal excitability, as indicated by an elevated threshold for motor evoked potentials (MEP), and increase intracortical excitability, as indicated by reduced intracortical inhibition. Ten patients with pre- or perinatally acquired, unilateral cortico-subcortical infarctions in the middle cerebral artery territory were studied with single pulse transcranial magnetic stimulation (TMS) to measure motor threshold (MT) and with paired pulse TMS to study short interval intracortical inhibition (SICI) and intracortical facilitation (ICF). Eight healthy, age-matched subjects served as controls. MT over the affected hemisphere of patients compared with the dominant hemisphere of controls was significantly elevated, reflecting reduced corticospinal excitability, and SICI was significantly reduced, reflecting increased intracortical excitability. No such differences were found for ICF. Findings in patients with congenital stroke were comparable with adulthood stroke. Thus, similar assumptions can be made: reduced corticospinal excitability is probably a consequence of neuronal damage. Reduced intracortical inhibition might represent deficient inhibitory cortical properties or might reflect a compensational mechanism, dispositioning for use-dependent plasticity. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/18043504/Abnormal_motor_cortex_excitability_in_congenital_stroke_ L2 - https://doi.org/10.1203/PDR.0b013e31815b88f1 DB - PRIME DP - Unbound Medicine ER -