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[Clinical forms of neuroborreliosis among hospitalized patients in the years 2000-2005].
Pol Merkur Lekarski. 2007 Aug; 23(134):103-6.PM

Abstract

THE AIM OF THE STUDY

To evaluate the frequency of clinical forms as well as laboratory and neuroimaging results of patients with diagnosed neuroborreliosis in the years 2000-2005 due to neuroborreliosis.

MATERIAL AND METHODS

The records of 125 patients at the age of 21-83 (mean 49 years) treated in the years 2000-2005 in the Department of Infectious Diseases and Neuroinfections, Medical University, Bialystok were subject to retrospective analysis. Diagnosis was based on case history along with a clinical picture and presence of antibodies against Borrelia burgdorferi, using ELISA test (Borrelia IgM and Borrelia IgG recombinant Biomedica). The subject of the detailed analysis was demographic data, clinical symptoms as well as subjective complaints, results of neurological examinations, the results of cerebrospinal fluid (CSF) parameters and results of serologic tests.

RESULTS

The most frequent clinical symptoms observed were: headaches 71%, vertigo 44%, meningeal symptoms 22% and neurological paresis 27% (including facial palsy--23%). Inflammatory changes in CSF in the form of increased proteins concentration and pleocytosis were present among 34% of patients. In all cases the antibodies against B. burgdorferi were present in CSF in diagnostically significant titer. Serum presence of antibodies antiborrelia IgM was found with 55% of patients and anibodies antiborrelia IgG with 76% of patients. 17% of patients suffering from neuroborreliosis were also coinfected with tick-borne encephalitis virus. Along with the neurological symptoms, which were crucial to diagnosis, general symptoms coexisted, such as: weakness 35%, arthralgia 54% and nausea 17%. In the analyzed period of time neuroborreliosis was diagnosed in a 13% of hospitalized patient suffering from borreliosis.

CONCLUSIONS

Absence of erythema migrans does not exclude existence of neuroborreliosis. Symptoms that may suggest presence of neuroborreliosis are not only neurological symptoms such as facial palsy, but also memory and concentration disorders and general symptoms.

Authors+Show Affiliations

Akademia Medyczna w Białymstoku, Klinika Chorób Zakaźnych i Neuroinfekcji. avalon-5@wp.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

18044338

Citation

Czupryna, Piotr, et al. "[Clinical Forms of Neuroborreliosis Among Hospitalized Patients in the Years 2000-2005]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 23, no. 134, 2007, pp. 103-6.
Czupryna P, Kuśmierczyk J, Zajkowska JM, et al. [Clinical forms of neuroborreliosis among hospitalized patients in the years 2000-2005]. Pol Merkur Lekarski. 2007;23(134):103-6.
Czupryna, P., Kuśmierczyk, J., Zajkowska, J. M., Ciemerych, M., Kondrusik, M., Ciemerych, A., & Pancewicz, S. A. (2007). [Clinical forms of neuroborreliosis among hospitalized patients in the years 2000-2005]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 23(134), 103-6.
Czupryna P, et al. [Clinical Forms of Neuroborreliosis Among Hospitalized Patients in the Years 2000-2005]. Pol Merkur Lekarski. 2007;23(134):103-6. PubMed PMID: 18044338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical forms of neuroborreliosis among hospitalized patients in the years 2000-2005]. AU - Czupryna,Piotr, AU - Kuśmierczyk,Justyna, AU - Zajkowska,Joanna M, AU - Ciemerych,Mariusz, AU - Kondrusik,Maciej, AU - Ciemerych,Aleksandra, AU - Pancewicz,Sławomir A, PY - 2007/11/30/pubmed PY - 2008/2/1/medline PY - 2007/11/30/entrez SP - 103 EP - 6 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 23 IS - 134 N2 - THE AIM OF THE STUDY: To evaluate the frequency of clinical forms as well as laboratory and neuroimaging results of patients with diagnosed neuroborreliosis in the years 2000-2005 due to neuroborreliosis. MATERIAL AND METHODS: The records of 125 patients at the age of 21-83 (mean 49 years) treated in the years 2000-2005 in the Department of Infectious Diseases and Neuroinfections, Medical University, Bialystok were subject to retrospective analysis. Diagnosis was based on case history along with a clinical picture and presence of antibodies against Borrelia burgdorferi, using ELISA test (Borrelia IgM and Borrelia IgG recombinant Biomedica). The subject of the detailed analysis was demographic data, clinical symptoms as well as subjective complaints, results of neurological examinations, the results of cerebrospinal fluid (CSF) parameters and results of serologic tests. RESULTS: The most frequent clinical symptoms observed were: headaches 71%, vertigo 44%, meningeal symptoms 22% and neurological paresis 27% (including facial palsy--23%). Inflammatory changes in CSF in the form of increased proteins concentration and pleocytosis were present among 34% of patients. In all cases the antibodies against B. burgdorferi were present in CSF in diagnostically significant titer. Serum presence of antibodies antiborrelia IgM was found with 55% of patients and anibodies antiborrelia IgG with 76% of patients. 17% of patients suffering from neuroborreliosis were also coinfected with tick-borne encephalitis virus. Along with the neurological symptoms, which were crucial to diagnosis, general symptoms coexisted, such as: weakness 35%, arthralgia 54% and nausea 17%. In the analyzed period of time neuroborreliosis was diagnosed in a 13% of hospitalized patient suffering from borreliosis. CONCLUSIONS: Absence of erythema migrans does not exclude existence of neuroborreliosis. Symptoms that may suggest presence of neuroborreliosis are not only neurological symptoms such as facial palsy, but also memory and concentration disorders and general symptoms. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/18044338/[Clinical_forms_of_neuroborreliosis_among_hospitalized_patients_in_the_years_2000_2005]_ DB - PRIME DP - Unbound Medicine ER -