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[Reactive oxygen and nitrogen species in inflammatory process].
Pol Merkur Lekarski. 2007 Aug; 23(134):131-6.PM

Abstract

Reactive oxygen species (ROS) are generated in every cell during normal oxidation. The most important ROS include: superoxide anion (O2*-), hydroxyl radical (OH*), hydroperoxyl radical (HO2*), hydrogen peroxide (H2O2) and singlet oxygen ((1)O2*-). Reactive oxygen species can react with key cellular structures and molecules altering their biological function. Similarly reactive nitrogen species (RNS) such as nitric oxide (NO) or peroxinitrite anion (ONOO-) have physiological activity or reacts with different types of molecules to form toxic products. ROS and RNS are important in process of energy generation, lipids peroxidation, protein and DNA oxidation, nitration, nitrosation or nitrosylation and catecholamine response. Reactive oxygen/nitrogen species are neutralized by enzymatic activity or natural antioxidants that stop the initial formation of radicals. Overproduction of ROS or RNS results in "oxidative" or "nitrosative" stress which contributes to variety of pathological processes typical for different cancer, neurodegenerative, viral, toxic or inflammatory diseases.

Authors+Show Affiliations

Rutkowski R
Akademia Medyczna w Białymstoku, Samodzielna Pracownia Diagnostyki Oddechowej i Bronchoskopii. rutkowski@csk.pl
Pancewicz SA
No affiliation info available
Rutkowski K
No affiliation info available
Rutkowska J
No affiliation info available

MeSH

AnimalsAntioxidantsHumansHydrogen PeroxideHydroxyl RadicalInflammationNeoplasmsNitric OxideOxidation-ReductionOxidative StressReactive Nitrogen SpeciesReactive Oxygen SpeciesSuperoxide DismutaseSuperoxides

Pub Type(s)

English Abstract
Journal Article
Review

Language

pol

PubMed ID

18044345

Citation

Rutkowski, Ryszard, et al. "[Reactive Oxygen and Nitrogen Species in Inflammatory Process]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 23, no. 134, 2007, pp. 131-6.
Rutkowski R, Pancewicz SA, Rutkowski K, et al. [Reactive oxygen and nitrogen species in inflammatory process]. Pol Merkur Lekarski. 2007;23(134):131-6.
Rutkowski, R., Pancewicz, S. A., Rutkowski, K., & Rutkowska, J. (2007). [Reactive oxygen and nitrogen species in inflammatory process]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 23(134), 131-6.
Rutkowski R, et al. [Reactive Oxygen and Nitrogen Species in Inflammatory Process]. Pol Merkur Lekarski. 2007;23(134):131-6. PubMed PMID: 18044345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Reactive oxygen and nitrogen species in inflammatory process]. AU - Rutkowski,Ryszard, AU - Pancewicz,Sławomir A, AU - Rutkowski,Krzysztof, AU - Rutkowska,Joanna, PY - 2007/11/30/pubmed PY - 2008/2/1/medline PY - 2007/11/30/entrez SP - 131 EP - 6 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol Merkur Lekarski VL - 23 IS - 134 N2 - Reactive oxygen species (ROS) are generated in every cell during normal oxidation. The most important ROS include: superoxide anion (O2*-), hydroxyl radical (OH*), hydroperoxyl radical (HO2*), hydrogen peroxide (H2O2) and singlet oxygen ((1)O2*-). Reactive oxygen species can react with key cellular structures and molecules altering their biological function. Similarly reactive nitrogen species (RNS) such as nitric oxide (NO) or peroxinitrite anion (ONOO-) have physiological activity or reacts with different types of molecules to form toxic products. ROS and RNS are important in process of energy generation, lipids peroxidation, protein and DNA oxidation, nitration, nitrosation or nitrosylation and catecholamine response. Reactive oxygen/nitrogen species are neutralized by enzymatic activity or natural antioxidants that stop the initial formation of radicals. Overproduction of ROS or RNS results in "oxidative" or "nitrosative" stress which contributes to variety of pathological processes typical for different cancer, neurodegenerative, viral, toxic or inflammatory diseases. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/18044345/[Reactive_oxygen_and_nitrogen_species_in_inflammatory_process]_ DB - PRIME DP - Unbound Medicine ER -