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An evaluation of octogenarians undergoing percutaneous coronary intervention from the Melbourne Interventional Group registry.
Catheter Cardiovasc Interv. 2007 Dec 01; 70(7):928-36.CC

Abstract

OBJECTIVES

The objective of this study was to evaluate the clinical characteristics and outcomes of octogenarians (> or =80 years of age) in a contemporary, multi-centre percutaneous coronary intervention (PCI) registry.

BACKGROUND

Octogenarians are increasingly referred for PCI. This patient population frequently has significant comorbidities, which result in major therapeutic challenges.

METHODS

The study population consisted of consecutive patients undergoing PCI in seven major Australian hospitals, who were treated over a 2-year period (2004-2005).

RESULTS

Of 4,360 PCI's, 11.3% (n = 491) were performed in octogenarians and 88.7% (n = 3,869) in patients <80 years. Octogenarians (compared with patients <80 years of age) were more likely female and have greater comorbidities such as cerebrovascular disease, renal impairment, congestive heart failure, and chronic airway disease. Octogenarians more frequently presented with acute coronary syndromes and cardiogenic shock. Octogenarians had significantly increased 30-day (6.0 vs. 1.4%, P < 0.01) and 12-month mortality (8.4% vs. 2.5%, P < 0.01), and major adverse cardiac event rates [(MACE), 30 days 11.3% vs. 5.4%, P < 0.01 and 12-months 18.7% vs. 12.9%, P = 0.04]. Cardiogenic shock, ST-segment elevation myocardial infarction, chronic renal failure, and age > or =80 years were independent predictors of 12-month mortality.

CONCLUSIONS

Octogenarians comprise a significant cohort of patients undergoing PCI. Octogenarians have more comorbidities, and higher rates of mortality and MACE, mandating thorough clinical evaluation before acceptance for PCI.

Authors+Show Affiliations

Department of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18044763

Citation

Yan, Bryan P., et al. "An Evaluation of Octogenarians Undergoing Percutaneous Coronary Intervention From the Melbourne Interventional Group Registry." Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, vol. 70, no. 7, 2007, pp. 928-36.
Yan BP, Gurvitch R, Duffy SJ, et al. An evaluation of octogenarians undergoing percutaneous coronary intervention from the Melbourne Interventional Group registry. Catheter Cardiovasc Interv. 2007;70(7):928-36.
Yan, B. P., Gurvitch, R., Duffy, S. J., Clark, D. J., Sebastian, M., New, G., Warren, R., Lefkovits, J., Lew, R., Brennan, A. L., Reid, C., Andrianopoulos, N., & Ajani, A. E. (2007). An evaluation of octogenarians undergoing percutaneous coronary intervention from the Melbourne Interventional Group registry. Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, 70(7), 928-36.
Yan BP, et al. An Evaluation of Octogenarians Undergoing Percutaneous Coronary Intervention From the Melbourne Interventional Group Registry. Catheter Cardiovasc Interv. 2007 Dec 1;70(7):928-36. PubMed PMID: 18044763.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An evaluation of octogenarians undergoing percutaneous coronary intervention from the Melbourne Interventional Group registry. AU - Yan,Bryan P, AU - Gurvitch,Ronen, AU - Duffy,Stephen J, AU - Clark,David J, AU - Sebastian,Martin, AU - New,Gishel, AU - Warren,Roderick, AU - Lefkovits,Jeffery, AU - Lew,Robert, AU - Brennan,Angela L, AU - Reid,Chris, AU - Andrianopoulos,Nick, AU - Ajani,Andrew E, PY - 2007/11/30/pubmed PY - 2008/2/8/medline PY - 2007/11/30/entrez SP - 928 EP - 36 JF - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions JO - Catheter Cardiovasc Interv VL - 70 IS - 7 N2 - OBJECTIVES: The objective of this study was to evaluate the clinical characteristics and outcomes of octogenarians (> or =80 years of age) in a contemporary, multi-centre percutaneous coronary intervention (PCI) registry. BACKGROUND: Octogenarians are increasingly referred for PCI. This patient population frequently has significant comorbidities, which result in major therapeutic challenges. METHODS: The study population consisted of consecutive patients undergoing PCI in seven major Australian hospitals, who were treated over a 2-year period (2004-2005). RESULTS: Of 4,360 PCI's, 11.3% (n = 491) were performed in octogenarians and 88.7% (n = 3,869) in patients <80 years. Octogenarians (compared with patients <80 years of age) were more likely female and have greater comorbidities such as cerebrovascular disease, renal impairment, congestive heart failure, and chronic airway disease. Octogenarians more frequently presented with acute coronary syndromes and cardiogenic shock. Octogenarians had significantly increased 30-day (6.0 vs. 1.4%, P < 0.01) and 12-month mortality (8.4% vs. 2.5%, P < 0.01), and major adverse cardiac event rates [(MACE), 30 days 11.3% vs. 5.4%, P < 0.01 and 12-months 18.7% vs. 12.9%, P = 0.04]. Cardiogenic shock, ST-segment elevation myocardial infarction, chronic renal failure, and age > or =80 years were independent predictors of 12-month mortality. CONCLUSIONS: Octogenarians comprise a significant cohort of patients undergoing PCI. Octogenarians have more comorbidities, and higher rates of mortality and MACE, mandating thorough clinical evaluation before acceptance for PCI. SN - 1522-1946 UR - https://www.unboundmedicine.com/medline/citation/18044763/An_evaluation_of_octogenarians_undergoing_percutaneous_coronary_intervention_from_the_Melbourne_Interventional_Group_registry_ L2 - https://doi.org/10.1002/ccd.21303 DB - PRIME DP - Unbound Medicine ER -