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Predictive factors for organic central precocious puberty and utility of simplified gonadotropin-releasing hormone tests.
Pediatr Int. 2007 Dec; 49(6):806-10.PI

Abstract

BACKGROUND

The aim of the present study was to determine whether the clinical presentation of patients with central precocious puberty (CPP) permits differentiation between idiopathic and organic forms, and to examine whether luteinizing hormone (LH) determination in single blood sample after gonadotropin-releasing hormone (GnRH) administration is sufficient to diagnose CPP.

METHODS

Potential clinical and laboratory predictors for the presence of central nervous system (CNS) abnormalities were assessed. Sensitivities and specificities of LH and follicle-stimulating hormone (FSH) levels at 0, 15, 30, 60, 90 and 120 min were compared after GnRH stimulation.

RESULTS

In 45 girls with signs of breast development, 26 were diagnosed as having CPP. The age of onset in patients with organic CPP was 4.75 +/- 2.01 years (range 1.2-7.1 years, median 5.0 years), whereas the age in patients with idiopathic CPP was 7.09 +/- 0.87 years (range 5.0-7.9 years, median 7.0 years). This parameter is the only one showing statistical significance. In addition, the specimen at 30 min after GnRH stimulation yielded highest sensitivity for the diagnosis of CPP.

CONCLUSIONS

The earlier the onset of disease, the higher the possibility of presence of CNS lesion. According to the mean GnRH-stimulated LH levels and sensitivity at each time, a single blood sample obtained for LH determined after GnRH administration at 30 min can be used to diagnose CPP.

Authors+Show Affiliations

Department of Pediatrics, Chungnam National University Hospital, College of Medicine, Chungnam National University, Daejeon, Korea.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18045276

Citation

Choi, Jin-Ho, et al. "Predictive Factors for Organic Central Precocious Puberty and Utility of Simplified Gonadotropin-releasing Hormone Tests." Pediatrics International : Official Journal of the Japan Pediatric Society, vol. 49, no. 6, 2007, pp. 806-10.
Choi JH, Shin YL, Yoo HW. Predictive factors for organic central precocious puberty and utility of simplified gonadotropin-releasing hormone tests. Pediatr Int. 2007;49(6):806-10.
Choi, J. H., Shin, Y. L., & Yoo, H. W. (2007). Predictive factors for organic central precocious puberty and utility of simplified gonadotropin-releasing hormone tests. Pediatrics International : Official Journal of the Japan Pediatric Society, 49(6), 806-10.
Choi JH, Shin YL, Yoo HW. Predictive Factors for Organic Central Precocious Puberty and Utility of Simplified Gonadotropin-releasing Hormone Tests. Pediatr Int. 2007;49(6):806-10. PubMed PMID: 18045276.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predictive factors for organic central precocious puberty and utility of simplified gonadotropin-releasing hormone tests. AU - Choi,Jin-Ho, AU - Shin,Young-Lim, AU - Yoo,Han-Wook, PY - 2007/11/30/pubmed PY - 2008/2/27/medline PY - 2007/11/30/entrez SP - 806 EP - 10 JF - Pediatrics international : official journal of the Japan Pediatric Society JO - Pediatr Int VL - 49 IS - 6 N2 - BACKGROUND: The aim of the present study was to determine whether the clinical presentation of patients with central precocious puberty (CPP) permits differentiation between idiopathic and organic forms, and to examine whether luteinizing hormone (LH) determination in single blood sample after gonadotropin-releasing hormone (GnRH) administration is sufficient to diagnose CPP. METHODS: Potential clinical and laboratory predictors for the presence of central nervous system (CNS) abnormalities were assessed. Sensitivities and specificities of LH and follicle-stimulating hormone (FSH) levels at 0, 15, 30, 60, 90 and 120 min were compared after GnRH stimulation. RESULTS: In 45 girls with signs of breast development, 26 were diagnosed as having CPP. The age of onset in patients with organic CPP was 4.75 +/- 2.01 years (range 1.2-7.1 years, median 5.0 years), whereas the age in patients with idiopathic CPP was 7.09 +/- 0.87 years (range 5.0-7.9 years, median 7.0 years). This parameter is the only one showing statistical significance. In addition, the specimen at 30 min after GnRH stimulation yielded highest sensitivity for the diagnosis of CPP. CONCLUSIONS: The earlier the onset of disease, the higher the possibility of presence of CNS lesion. According to the mean GnRH-stimulated LH levels and sensitivity at each time, a single blood sample obtained for LH determined after GnRH administration at 30 min can be used to diagnose CPP. SN - 1328-8067 UR - https://www.unboundmedicine.com/medline/citation/18045276/Predictive_factors_for_organic_central_precocious_puberty_and_utility_of_simplified_gonadotropin_releasing_hormone_tests_ L2 - https://doi.org/10.1111/j.1442-200X.2007.02475.x DB - PRIME DP - Unbound Medicine ER -