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Alexander's disease: a report and reappraisal.
Neurology. 1976 Jul; 26(7):607-14.Neur

Abstract

A boy with juvenile onset of symptoms of Alexander's disease had a clinical picture of pseudobulbar palsy, ataxia, and spastic paraparesis. Pathologic examination of the central nervous system revealed the diffuse presence of Rosenthal fibers and patchy demyelination. This may be the first report of a case with significant neuronal changes and inflammation within the brain stem in this disease. The clinical picture of this entity is varied and age-dependent. Alexander's disease may be a motor system specific entity secondary to astrocytic dysfunction.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

180453

Citation

Russo, L S., et al. "Alexander's Disease: a Report and Reappraisal." Neurology, vol. 26, no. 7, 1976, pp. 607-14.
Russo LS, Aron A, Anderson PJ. Alexander's disease: a report and reappraisal. Neurology. 1976;26(7):607-14.
Russo, L. S., Aron, A., & Anderson, P. J. (1976). Alexander's disease: a report and reappraisal. Neurology, 26(7), 607-14.
Russo LS, Aron A, Anderson PJ. Alexander's Disease: a Report and Reappraisal. Neurology. 1976;26(7):607-14. PubMed PMID: 180453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alexander's disease: a report and reappraisal. AU - Russo,L S,Jr AU - Aron,A, AU - Anderson,P J, PY - 1976/7/1/pubmed PY - 2001/3/28/medline PY - 1976/7/1/entrez SP - 607 EP - 14 JF - Neurology JO - Neurology VL - 26 IS - 7 N2 - A boy with juvenile onset of symptoms of Alexander's disease had a clinical picture of pseudobulbar palsy, ataxia, and spastic paraparesis. Pathologic examination of the central nervous system revealed the diffuse presence of Rosenthal fibers and patchy demyelination. This may be the first report of a case with significant neuronal changes and inflammation within the brain stem in this disease. The clinical picture of this entity is varied and age-dependent. Alexander's disease may be a motor system specific entity secondary to astrocytic dysfunction. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/180453/Alexander's_disease:_a_report_and_reappraisal_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=180453.ui DB - PRIME DP - Unbound Medicine ER -