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Interaction of vitamins C and E as better cosmeceuticals.
Dermatol Ther. 2007 Sep-Oct; 20(5):314-21.DT

Abstract

Although many cosmeceutical formulations contain vitamin C and/or vitamin E, very few are actually effective in topical application. First because there is only a low concentration, second because the stability is compromised as soon as the product is opened and exposed to air and light, and third because the form of the molecule (an ester or a mixture of isomers) is not absorbed or metabolized effectively by the skin. However, when a stable formulation delivers a high concentration of the nonesterified, optimal isomer of the antioxidant, vitamins C and E do indeed inhibit the acute ultraviolet (UV) damage of erythema, sunburn, and tanning as well as chronic UV photoaging and skin cancer. Both are highly effective depigmenting agents. Topical vitamin C also increases collagen synthesis in both young and old fibroblasts. Because vitamin C regenerates oxidized vitamin E, the combination in a cosmeceutical formulation is synergistic - particularly in UV protection.

Authors+Show Affiliations

Department of Dermatology, Mount Sinai Medical Center, New York, USA. kebmdphd@gmail.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18045356

Citation

Burke, Karen E.. "Interaction of Vitamins C and E as Better Cosmeceuticals." Dermatologic Therapy, vol. 20, no. 5, 2007, pp. 314-21.
Burke KE. Interaction of vitamins C and E as better cosmeceuticals. Dermatol Ther. 2007;20(5):314-21.
Burke, K. E. (2007). Interaction of vitamins C and E as better cosmeceuticals. Dermatologic Therapy, 20(5), 314-21.
Burke KE. Interaction of Vitamins C and E as Better Cosmeceuticals. Dermatol Ther. 2007 Sep-Oct;20(5):314-21. PubMed PMID: 18045356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of vitamins C and E as better cosmeceuticals. A1 - Burke,Karen E, PY - 2007/11/30/pubmed PY - 2008/2/6/medline PY - 2007/11/30/entrez SP - 314 EP - 21 JF - Dermatologic therapy JO - Dermatol Ther VL - 20 IS - 5 N2 - Although many cosmeceutical formulations contain vitamin C and/or vitamin E, very few are actually effective in topical application. First because there is only a low concentration, second because the stability is compromised as soon as the product is opened and exposed to air and light, and third because the form of the molecule (an ester or a mixture of isomers) is not absorbed or metabolized effectively by the skin. However, when a stable formulation delivers a high concentration of the nonesterified, optimal isomer of the antioxidant, vitamins C and E do indeed inhibit the acute ultraviolet (UV) damage of erythema, sunburn, and tanning as well as chronic UV photoaging and skin cancer. Both are highly effective depigmenting agents. Topical vitamin C also increases collagen synthesis in both young and old fibroblasts. Because vitamin C regenerates oxidized vitamin E, the combination in a cosmeceutical formulation is synergistic - particularly in UV protection. SN - 1529-8019 UR - https://www.unboundmedicine.com/medline/citation/18045356/Interaction_of_vitamins_C_and_E_as_better_cosmeceuticals_ L2 - https://doi.org/10.1111/j.1529-8019.2007.00145.x DB - PRIME DP - Unbound Medicine ER -