Tags

Type your tag names separated by a space and hit enter

Factors associated with undiagnosed open-angle glaucoma: the Thessaloniki Eye Study.
Am J Ophthalmol 2008; 145(2):327-335AJ

Abstract

PURPOSE

To identify factors associated with undiagnosed open-angle glaucoma (OAG), primary open-angle glaucoma (POAG), and pseudoexfoliative glaucoma (PEXG) in an elderly population in Thessaloniki, Greece.

DESIGN

Cross-sectional population-based study.

METHODS

Randomly selected subjects > or =60 years (n = 2,554) participated in the study. Subjects were classified as having POAG or PEXG according to specific criteria and using a two-scale definition of glaucoma. Undiagnosed glaucoma was defined as absence of either prior diagnosis of glaucoma or ocular hypertension or prior medical treatment for glaucoma or prior glaucoma surgery. Logistic regression analyses were performed with age, gender, family history of glaucoma, history of cataract surgery, visual acuity, vertical cup-to-disk (C/D) ratio, intraocular pressure, Advanced Glaucoma Intervention Study visual field score, time since last eye doctor visit, and type of OAG as covariates.

RESULTS

The prevalence of undiagnosed glaucoma was 57.1% (56/98) for POAG, significantly higher than the prevalence of 34.9% (15/43) for PEXG (P = .017). POAG patients presented three to four times increased risk to be undiagnosed compared with PEXG patients (P = .02 and P = .04, respectively). Patients with OAG who had not visited an ophthalmologist during the last year had six times an increased risk to be undiagnosed (P = .003). In POAG, smaller vertical C/D ratio was statistically significantly associated with an increased risk to be undiagnosed (P = .008).

CONCLUSIONS

Lack of regular visits to an ophthalmologist was a major factor for undiagnosed OAG. POAG was more likely to be undiagnosed than PEXG. Since C/D ratio was associated with undiagnosed POAG, standardized protocols involving thorough evaluation of the optic disk are recommended for ophthalmologists.

Authors+Show Affiliations

II Department of Ophthalmology, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Periferiaki Odos Thessalonikis N. Efkarpia 56403, Thessaloniki, Greece. ftopouzis@otenet.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18045565

Citation

Topouzis, Fotis, et al. "Factors Associated With Undiagnosed Open-angle Glaucoma: the Thessaloniki Eye Study." American Journal of Ophthalmology, vol. 145, no. 2, 2008, pp. 327-335.
Topouzis F, Coleman AL, Harris A, et al. Factors associated with undiagnosed open-angle glaucoma: the Thessaloniki Eye Study. Am J Ophthalmol. 2008;145(2):327-335.
Topouzis, F., Coleman, A. L., Harris, A., Koskosas, A., Founti, P., Gong, G., ... Wilson, M. R. (2008). Factors associated with undiagnosed open-angle glaucoma: the Thessaloniki Eye Study. American Journal of Ophthalmology, 145(2), pp. 327-335.
Topouzis F, et al. Factors Associated With Undiagnosed Open-angle Glaucoma: the Thessaloniki Eye Study. Am J Ophthalmol. 2008;145(2):327-335. PubMed PMID: 18045565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with undiagnosed open-angle glaucoma: the Thessaloniki Eye Study. AU - Topouzis,Fotis, AU - Coleman,Anne L, AU - Harris,Alon, AU - Koskosas,Archimidis, AU - Founti,Panayiota, AU - Gong,Gordon, AU - Yu,Fei, AU - Anastasopoulos,Eleftherios, AU - Pappas,Theofanis, AU - Wilson,M Roy, Y1 - 2007/11/28/ PY - 2007/06/28/received PY - 2007/09/10/revised PY - 2007/09/11/accepted PY - 2007/11/30/pubmed PY - 2008/3/21/medline PY - 2007/11/30/entrez SP - 327 EP - 335 JF - American journal of ophthalmology JO - Am. J. Ophthalmol. VL - 145 IS - 2 N2 - PURPOSE: To identify factors associated with undiagnosed open-angle glaucoma (OAG), primary open-angle glaucoma (POAG), and pseudoexfoliative glaucoma (PEXG) in an elderly population in Thessaloniki, Greece. DESIGN: Cross-sectional population-based study. METHODS: Randomly selected subjects > or =60 years (n = 2,554) participated in the study. Subjects were classified as having POAG or PEXG according to specific criteria and using a two-scale definition of glaucoma. Undiagnosed glaucoma was defined as absence of either prior diagnosis of glaucoma or ocular hypertension or prior medical treatment for glaucoma or prior glaucoma surgery. Logistic regression analyses were performed with age, gender, family history of glaucoma, history of cataract surgery, visual acuity, vertical cup-to-disk (C/D) ratio, intraocular pressure, Advanced Glaucoma Intervention Study visual field score, time since last eye doctor visit, and type of OAG as covariates. RESULTS: The prevalence of undiagnosed glaucoma was 57.1% (56/98) for POAG, significantly higher than the prevalence of 34.9% (15/43) for PEXG (P = .017). POAG patients presented three to four times increased risk to be undiagnosed compared with PEXG patients (P = .02 and P = .04, respectively). Patients with OAG who had not visited an ophthalmologist during the last year had six times an increased risk to be undiagnosed (P = .003). In POAG, smaller vertical C/D ratio was statistically significantly associated with an increased risk to be undiagnosed (P = .008). CONCLUSIONS: Lack of regular visits to an ophthalmologist was a major factor for undiagnosed OAG. POAG was more likely to be undiagnosed than PEXG. Since C/D ratio was associated with undiagnosed POAG, standardized protocols involving thorough evaluation of the optic disk are recommended for ophthalmologists. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/18045565/Factors_associated_with_undiagnosed_open_angle_glaucoma:_the_Thessaloniki_Eye_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(07)00804-5 DB - PRIME DP - Unbound Medicine ER -