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Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia.
Phytochemistry. 2008 Feb; 69(4):1043-8.P

Abstract

Five cucurbitacins, kuguacins A-E (1-5), together with three known analogues, 3beta,7beta,25-trihydroxycucurbita-5,(23E)-diene-19-al (6), 3beta,25-dihydroxy-5beta,19-epoxycucurbita-6,(23E)-diene (7), and momordicine I (8), were isolated from roots of Momordica charantia. Structures of 1-5 were elucidated by NMR and MS spectroscopic analysis. Among them, compounds 3-5 possess an unprecedented 25,26,27-trinorcucurbitane backbone. Compounds 3 and 5 showed moderate anti-HIV-1 activity with EC(50) values of 8.45 and 25.62 microg/ml, and exerted minimal cytotoxicity against C8166 cells (IC(50)>200 microg/ml), with a selectivity index more than 23.68 and 7.81, respectively.

Authors+Show Affiliations

Chen J
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
Tian R
No affiliation info available
Qiu M
No affiliation info available
Lu L
No affiliation info available
Zheng Y
No affiliation info available
Zhang Z
No affiliation info available

MeSH

Cell LineCell SurvivalCucurbitacinsGlycosidesHumansMomordica charantiaPlant RootsTriterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18045630

Citation

Chen, Jianchao, et al. "Trinorcucurbitane and Cucurbitane Triterpenoids From the Roots of Momordica Charantia." Phytochemistry, vol. 69, no. 4, 2008, pp. 1043-8.
Chen J, Tian R, Qiu M, et al. Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. Phytochemistry. 2008;69(4):1043-8.
Chen, J., Tian, R., Qiu, M., Lu, L., Zheng, Y., & Zhang, Z. (2008). Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. Phytochemistry, 69(4), 1043-8.
Chen J, et al. Trinorcucurbitane and Cucurbitane Triterpenoids From the Roots of Momordica Charantia. Phytochemistry. 2008;69(4):1043-8. PubMed PMID: 18045630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia. AU - Chen,Jianchao, AU - Tian,Renrong, AU - Qiu,Minghua, AU - Lu,Lu, AU - Zheng,Yongtang, AU - Zhang,Zhongquan, Y1 - 2007/11/28/ PY - 2007/05/16/received PY - 2007/08/17/revised PY - 2007/10/15/accepted PY - 2007/11/30/pubmed PY - 2008/7/29/medline PY - 2007/11/30/entrez SP - 1043 EP - 8 JF - Phytochemistry JO - Phytochemistry VL - 69 IS - 4 N2 - Five cucurbitacins, kuguacins A-E (1-5), together with three known analogues, 3beta,7beta,25-trihydroxycucurbita-5,(23E)-diene-19-al (6), 3beta,25-dihydroxy-5beta,19-epoxycucurbita-6,(23E)-diene (7), and momordicine I (8), were isolated from roots of Momordica charantia. Structures of 1-5 were elucidated by NMR and MS spectroscopic analysis. Among them, compounds 3-5 possess an unprecedented 25,26,27-trinorcucurbitane backbone. Compounds 3 and 5 showed moderate anti-HIV-1 activity with EC(50) values of 8.45 and 25.62 microg/ml, and exerted minimal cytotoxicity against C8166 cells (IC(50)>200 microg/ml), with a selectivity index more than 23.68 and 7.81, respectively. SN - 0031-9422 UR - https://www.unboundmedicine.com/medline/citation/18045630/Trinorcucurbitane_and_cucurbitane_triterpenoids_from_the_roots_of_Momordica_charantia_ DB - PRIME DP - Unbound Medicine ER -