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[Transient hyperglycemia in acute myocardial infarct: the short- and long-term risk factor for mortality].
G Ital Cardiol 1991; 21(10):1047-56GI

Abstract

To evaluate the prevalence and prognostic significance of hyperglycemia in acute myocardial infarction, we studied 700 patients (mean age 63.3 +/- 10.97) subsequently admitted to the UCIC of Tradate Hospital during the period January 1976 to December 1987. Patients were followed up for a median period of four years. On the basis of fasting blood glycaemia values in the first five days of hospitalization, excluding the admission day, patients were divided into groups: 401 patients (57.0%) with constantly normal glycaemia; 84 patients (12.0%) with glycaemia equal or superior to 120 mg/100 ml, and with subsequent normalization; and 215 patients (31.0%) with diabetes mellitus diagnosed before hospitalization and/or with persistent hyperglycaemia. The overall mortality was 284 (40.5%) and cardiovascular deaths were 90.8%. Within the first month of myocardial infarction 98 patients died. The mortality rate was 9.4% in normoglycaemic patients and 20.2% in transient hyperglycaemic patients, similar to the value observed in diabetic patients (20.0%). During the follow-up 186 patients died. Late mortality after the first month is higher in diabetic patients (40%) and patients with transient hyperglycaemia (37%) compared to normoglycaemic patients (25.3%). Multivariate analysis shows that independent predictive variables are: for mortality in the first month, Killip class only; and after the first month, Killip class, metabolic classification, sex and supraventricular arrhythmias. The present study shows that transient hyperglycaemia has a low prevalence in the first days of acute myocardial infarction. Transient hyperglycaemia could be attributed not only to increased sympathetic tone elicited by acute myocardial infarction, but is probably a pathologic condition with an adverse outcome to which multiple factors contribute.

Authors+Show Affiliations

Servizio di Cardiologia e UCIC, Ospedale di Tradate.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

ita

PubMed ID

1804742

Citation

Gualtierotti, C, et al. "[Transient Hyperglycemia in Acute Myocardial Infarct: the Short- and Long-term Risk Factor for Mortality]." Giornale Italiano Di Cardiologia, vol. 21, no. 10, 1991, pp. 1047-56.
Gualtierotti C, Della Rosa C, Barbieri P, et al. [Transient hyperglycemia in acute myocardial infarct: the short- and long-term risk factor for mortality]. G Ital Cardiol. 1991;21(10):1047-56.
Gualtierotti, C., Della Rosa, C., Barbieri, P., Amati, L., Barbieri, D., Poggio, G. L., & Radice, M. (1991). [Transient hyperglycemia in acute myocardial infarct: the short- and long-term risk factor for mortality]. Giornale Italiano Di Cardiologia, 21(10), pp. 1047-56.
Gualtierotti C, et al. [Transient Hyperglycemia in Acute Myocardial Infarct: the Short- and Long-term Risk Factor for Mortality]. G Ital Cardiol. 1991;21(10):1047-56. PubMed PMID: 1804742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Transient hyperglycemia in acute myocardial infarct: the short- and long-term risk factor for mortality]. AU - Gualtierotti,C, AU - Della Rosa,C, AU - Barbieri,P, AU - Amati,L, AU - Barbieri,D, AU - Poggio,G L, AU - Radice,M, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 1047 EP - 56 JF - Giornale italiano di cardiologia JO - G Ital Cardiol VL - 21 IS - 10 N2 - To evaluate the prevalence and prognostic significance of hyperglycemia in acute myocardial infarction, we studied 700 patients (mean age 63.3 +/- 10.97) subsequently admitted to the UCIC of Tradate Hospital during the period January 1976 to December 1987. Patients were followed up for a median period of four years. On the basis of fasting blood glycaemia values in the first five days of hospitalization, excluding the admission day, patients were divided into groups: 401 patients (57.0%) with constantly normal glycaemia; 84 patients (12.0%) with glycaemia equal or superior to 120 mg/100 ml, and with subsequent normalization; and 215 patients (31.0%) with diabetes mellitus diagnosed before hospitalization and/or with persistent hyperglycaemia. The overall mortality was 284 (40.5%) and cardiovascular deaths were 90.8%. Within the first month of myocardial infarction 98 patients died. The mortality rate was 9.4% in normoglycaemic patients and 20.2% in transient hyperglycaemic patients, similar to the value observed in diabetic patients (20.0%). During the follow-up 186 patients died. Late mortality after the first month is higher in diabetic patients (40%) and patients with transient hyperglycaemia (37%) compared to normoglycaemic patients (25.3%). Multivariate analysis shows that independent predictive variables are: for mortality in the first month, Killip class only; and after the first month, Killip class, metabolic classification, sex and supraventricular arrhythmias. The present study shows that transient hyperglycaemia has a low prevalence in the first days of acute myocardial infarction. Transient hyperglycaemia could be attributed not only to increased sympathetic tone elicited by acute myocardial infarction, but is probably a pathologic condition with an adverse outcome to which multiple factors contribute. SN - 0046-5968 UR - https://www.unboundmedicine.com/medline/citation/1804742/[Transient_hyperglycemia_in_acute_myocardial_infarct:_the_short__and_long_term_risk_factor_for_mortality]_ L2 - https://medlineplus.gov/hyperglycemia.html DB - PRIME DP - Unbound Medicine ER -