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The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial.
J Cosmet Dermatol. 2007 Dec; 6(4):243-9.JC

Abstract

BACKGROUND

Kinetin and niacinamide are used in the cosmetic industry as anti-aging agents. Neither the interactive/additive effects of these compounds nor the anti-aging efficacy on Asian skin has been studied. Objective To assess the clinical anti-aging effects and efficacy differences between kinetin plus niacinamide and niacinamide alone vs. vehicle placebo in an Asian cohort.

METHODS

Fifty-two Taiwanese subjects were enrolled in a randomized, double-blind, placebo-controlled, split-face comparative study. Group 1 subjects were treated with kinetin 0.03% plus niacinamide 4%, whereas group 2 subjects received niacinamide 4%. The treatment formulation was applied on one side of the face, whereas a placebo was applied on the other for a period of 12 weeks. We used noninvasive biometrological instruments to evaluate a variety of skin parameters at baseline and at weeks 4, 8, and 12.

RESULTS

Persistent and significant reductions in spot, pore, wrinkle, and evenness counts were found at weeks 8 and 12 in group 1. A significant increase in corneal hydration status was also evident at week 12, whereas persistent decreases in erythema index were apparent at 8 and 12 weeks. In group 2, significant reductions in pore and evenness counts at week 8 and wrinkle counts at week 12 were noted.

CONCLUSION

We found kinetin and niacinamide exert a synergistic anti-aging effect. Our data suggest that these compounds have multiactive, multifunctional, and pluripotent effects on skin. They are also both promising to be included in the cutaneous anti-aging cosmeceuticals in the future.

Authors+Show Affiliations

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. pinchichiu@ntu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18047609

Citation

Chiu, Pin-Chi, et al. "The Clinical Anti-aging Effects of Topical Kinetin and Niacinamide in Asians: a Randomized, Double-blind, Placebo-controlled, Split-face Comparative Trial." Journal of Cosmetic Dermatology, vol. 6, no. 4, 2007, pp. 243-9.
Chiu PC, Chan CC, Lin HM, et al. The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. J Cosmet Dermatol. 2007;6(4):243-9.
Chiu, P. C., Chan, C. C., Lin, H. M., & Chiu, H. C. (2007). The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. Journal of Cosmetic Dermatology, 6(4), 243-9.
Chiu PC, et al. The Clinical Anti-aging Effects of Topical Kinetin and Niacinamide in Asians: a Randomized, Double-blind, Placebo-controlled, Split-face Comparative Trial. J Cosmet Dermatol. 2007;6(4):243-9. PubMed PMID: 18047609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial. AU - Chiu,Pin-Chi, AU - Chan,Chih-Chieh, AU - Lin,Hui-Min, AU - Chiu,Hsien-Ching, PY - 2007/12/1/pubmed PY - 2008/3/26/medline PY - 2007/12/1/entrez SP - 243 EP - 9 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 6 IS - 4 N2 - BACKGROUND: Kinetin and niacinamide are used in the cosmetic industry as anti-aging agents. Neither the interactive/additive effects of these compounds nor the anti-aging efficacy on Asian skin has been studied. Objective To assess the clinical anti-aging effects and efficacy differences between kinetin plus niacinamide and niacinamide alone vs. vehicle placebo in an Asian cohort. METHODS: Fifty-two Taiwanese subjects were enrolled in a randomized, double-blind, placebo-controlled, split-face comparative study. Group 1 subjects were treated with kinetin 0.03% plus niacinamide 4%, whereas group 2 subjects received niacinamide 4%. The treatment formulation was applied on one side of the face, whereas a placebo was applied on the other for a period of 12 weeks. We used noninvasive biometrological instruments to evaluate a variety of skin parameters at baseline and at weeks 4, 8, and 12. RESULTS: Persistent and significant reductions in spot, pore, wrinkle, and evenness counts were found at weeks 8 and 12 in group 1. A significant increase in corneal hydration status was also evident at week 12, whereas persistent decreases in erythema index were apparent at 8 and 12 weeks. In group 2, significant reductions in pore and evenness counts at week 8 and wrinkle counts at week 12 were noted. CONCLUSION: We found kinetin and niacinamide exert a synergistic anti-aging effect. Our data suggest that these compounds have multiactive, multifunctional, and pluripotent effects on skin. They are also both promising to be included in the cutaneous anti-aging cosmeceuticals in the future. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/18047609/The_clinical_anti_aging_effects_of_topical_kinetin_and_niacinamide_in_Asians:_a_randomized_double_blind_placebo_controlled_split_face_comparative_trial_ L2 - https://doi.org/10.1111/j.1473-2165.2007.00342.x DB - PRIME DP - Unbound Medicine ER -