Tags

Type your tag names separated by a space and hit enter

Ankle-brachial index and hemostatic markers in the Atherosclerosis Risk in Communities (ARIC) study cohort.
Vasc Med 2007; 12(4):267-73VM

Abstract

To determine whether elevated levels of hemostatic and inflammatory markers [von Willebrand factor (vWF), fibrinogen, D-dimer, factor VII, factor VIII, PAI-1, tPA, beta-thromboglobulin (beta-TG), CRP, and WBC count] are associated with increased peripheral arterial disease (PAD) prevalence, measured by low ABI, we studied 13,778 participants from the ARIC study in a cross-sectional analysis after adjustment for major cardiovascular risk factors. PAD was positively associated with fibrinogen, vWF, factor VIII, WBC count, D-dimer, beta-TG, and CRP (p for trend <0.05) but not with the other markers. Adjusted odds ratios for the highest versus the lowest quartile of fibrinogen in men and women, respectively, were 3.49 (95% CI 1.68-7.26) and 2.44 (95% CI 1.58-3.77); for vWF 2.36 (95% CI 1.36-4.07) and 1.45 (95% CI 1.00-2.10); for factor VIII 2.31 (95% CI 1.36-3.94) and 1.68 (95% CI 1.14-2.48). In a smaller subset, the sex and risk factor adjusted odds ratio for the highest versus the lowest quartile of D-dimer was 2.70 (95% CI 1.56-4.65), for beta-TG was 1.80 (95% CI 1.12-2.88), and for CRP was 1.57 (95% CI 0.84-2.95). Plasma levels of hemostatic and inflammatory markers are elevated in PAD, suggesting these processes are involved in the pathophysiology of PAD.

Authors+Show Affiliations

Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18048462

Citation

Reich, Laura M., et al. "Ankle-brachial Index and Hemostatic Markers in the Atherosclerosis Risk in Communities (ARIC) Study Cohort." Vascular Medicine (London, England), vol. 12, no. 4, 2007, pp. 267-73.
Reich LM, Heiss G, Boland LL, et al. Ankle-brachial index and hemostatic markers in the Atherosclerosis Risk in Communities (ARIC) study cohort. Vasc Med. 2007;12(4):267-73.
Reich, L. M., Heiss, G., Boland, L. L., Hirsch, A. T., Wu, K., & Folsom, A. R. (2007). Ankle-brachial index and hemostatic markers in the Atherosclerosis Risk in Communities (ARIC) study cohort. Vascular Medicine (London, England), 12(4), pp. 267-73.
Reich LM, et al. Ankle-brachial Index and Hemostatic Markers in the Atherosclerosis Risk in Communities (ARIC) Study Cohort. Vasc Med. 2007;12(4):267-73. PubMed PMID: 18048462.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ankle-brachial index and hemostatic markers in the Atherosclerosis Risk in Communities (ARIC) study cohort. AU - Reich,Laura M, AU - Heiss,Gerardo, AU - Boland,Lori L, AU - Hirsch,Alan T, AU - Wu,Kenneth, AU - Folsom,Aaron R, PY - 2007/12/1/pubmed PY - 2008/3/21/medline PY - 2007/12/1/entrez SP - 267 EP - 73 JF - Vascular medicine (London, England) JO - Vasc Med VL - 12 IS - 4 N2 - To determine whether elevated levels of hemostatic and inflammatory markers [von Willebrand factor (vWF), fibrinogen, D-dimer, factor VII, factor VIII, PAI-1, tPA, beta-thromboglobulin (beta-TG), CRP, and WBC count] are associated with increased peripheral arterial disease (PAD) prevalence, measured by low ABI, we studied 13,778 participants from the ARIC study in a cross-sectional analysis after adjustment for major cardiovascular risk factors. PAD was positively associated with fibrinogen, vWF, factor VIII, WBC count, D-dimer, beta-TG, and CRP (p for trend <0.05) but not with the other markers. Adjusted odds ratios for the highest versus the lowest quartile of fibrinogen in men and women, respectively, were 3.49 (95% CI 1.68-7.26) and 2.44 (95% CI 1.58-3.77); for vWF 2.36 (95% CI 1.36-4.07) and 1.45 (95% CI 1.00-2.10); for factor VIII 2.31 (95% CI 1.36-3.94) and 1.68 (95% CI 1.14-2.48). In a smaller subset, the sex and risk factor adjusted odds ratio for the highest versus the lowest quartile of D-dimer was 2.70 (95% CI 1.56-4.65), for beta-TG was 1.80 (95% CI 1.12-2.88), and for CRP was 1.57 (95% CI 0.84-2.95). Plasma levels of hemostatic and inflammatory markers are elevated in PAD, suggesting these processes are involved in the pathophysiology of PAD. SN - 1358-863X UR - https://www.unboundmedicine.com/medline/citation/18048462/Ankle_brachial_index_and_hemostatic_markers_in_the_Atherosclerosis_Risk_in_Communities__ARIC__study_cohort_ L2 - http://journals.sagepub.com/doi/full/10.1177/1358863X07082767?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -