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Changes in lens dimensions and refractive index with age and accommodation.
Optom Vis Sci. 2007 Oct; 84(10):990-5.OV

Abstract

PURPOSE

To measure changes in human eye lens dimensions and refractive index with age and state of accommodation.

METHODS

MRI methods were used to measure refractive index maps and lens geometry (diameter and thickness) of an axial slice through the lens in 44 volunteers aged 18 to 59 years, with an accommodation stimulus of 0.17 D (unaccommodated state). In a subpopulation of 26 young volunteers aged 18 to 33 years, lens dimensions were also measured in an accommodated (6.67 D stimulus) state. For a subpopulation of six of the young volunteers (22 to 33 years), refractive index maps were also acquired with an accommodation stimulus of 6.67 D.

RESULTS

Unaccommodated lens thickness increased significantly with age (T = 3.31 +/- 0.10 mm + 0.0180 +/- 0.0036 mm x Age; p < 0.0001). Lens diameter (D = 9.33 +/- 0.0033 mm) and central refractive index (nc = 1.4198 +/- 0.0067) showed no significant age dependence. Lens thickness increased (DeltaT = 0.050 +/- 0.024 mm/D) and diameter decreased (DeltaD = -0.067 +/- 0.030 mm/D) on accommodation. A slight decrease in central refractive index with accommodation was not statistically significant.

CONCLUSIONS

The results are consistent with the Helmholtz theory of accommodation.

Authors+Show Affiliations

School of Physical and Chemical Sciences, Queensland University of Technology, Brisbane, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18049365

Citation

Jones, Catherine E., et al. "Changes in Lens Dimensions and Refractive Index With Age and Accommodation." Optometry and Vision Science : Official Publication of the American Academy of Optometry, vol. 84, no. 10, 2007, pp. 990-5.
Jones CE, Atchison DA, Pope JM. Changes in lens dimensions and refractive index with age and accommodation. Optom Vis Sci. 2007;84(10):990-5.
Jones, C. E., Atchison, D. A., & Pope, J. M. (2007). Changes in lens dimensions and refractive index with age and accommodation. Optometry and Vision Science : Official Publication of the American Academy of Optometry, 84(10), 990-5.
Jones CE, Atchison DA, Pope JM. Changes in Lens Dimensions and Refractive Index With Age and Accommodation. Optom Vis Sci. 2007;84(10):990-5. PubMed PMID: 18049365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in lens dimensions and refractive index with age and accommodation. AU - Jones,Catherine E, AU - Atchison,David A, AU - Pope,James M, PY - 2007/12/1/pubmed PY - 2008/1/17/medline PY - 2007/12/1/entrez SP - 990 EP - 5 JF - Optometry and vision science : official publication of the American Academy of Optometry JO - Optom Vis Sci VL - 84 IS - 10 N2 - PURPOSE: To measure changes in human eye lens dimensions and refractive index with age and state of accommodation. METHODS: MRI methods were used to measure refractive index maps and lens geometry (diameter and thickness) of an axial slice through the lens in 44 volunteers aged 18 to 59 years, with an accommodation stimulus of 0.17 D (unaccommodated state). In a subpopulation of 26 young volunteers aged 18 to 33 years, lens dimensions were also measured in an accommodated (6.67 D stimulus) state. For a subpopulation of six of the young volunteers (22 to 33 years), refractive index maps were also acquired with an accommodation stimulus of 6.67 D. RESULTS: Unaccommodated lens thickness increased significantly with age (T = 3.31 +/- 0.10 mm + 0.0180 +/- 0.0036 mm x Age; p < 0.0001). Lens diameter (D = 9.33 +/- 0.0033 mm) and central refractive index (nc = 1.4198 +/- 0.0067) showed no significant age dependence. Lens thickness increased (DeltaT = 0.050 +/- 0.024 mm/D) and diameter decreased (DeltaD = -0.067 +/- 0.030 mm/D) on accommodation. A slight decrease in central refractive index with accommodation was not statistically significant. CONCLUSIONS: The results are consistent with the Helmholtz theory of accommodation. SN - 1040-5488 UR - https://www.unboundmedicine.com/medline/citation/18049365/Changes_in_lens_dimensions_and_refractive_index_with_age_and_accommodation_ L2 - http://dx.doi.org/10.1097/OPX.0b013e318157c6b5 DB - PRIME DP - Unbound Medicine ER -