Tags

Type your tag names separated by a space and hit enter

Herpes simplex virus-2 and HIV among noninjecting drug users in New York city.
Sex Transm Dis. 2007 Nov; 34(11):923-7.ST

Abstract

OBJECTIVE

To examine the relationship between herpes simplex virus 2 (HSV-2) seroprevalence and human immunodeficiency virus (HIV) seroprevalence among noninjecting heroin and cocaine users in New York City.

METHODS

Four hundred sixty-two noninjecting cocaine and heroin users were recruited from a drug detoxification program in New York City. Smoking crack cocaine, intranasal use of heroin, and intranasal use of cocaine were the most common types of drug use. A structured interview was administered and a serum sample was collected for HIV and HSV testing.

RESULTS

HIV prevalence was 19% (95% CI 15%-22%) and HSV-2 seroprevalence was 60% (95% CI 55%-64%). The adjusted risk ratio for the association between HSV-2 and HIV was 1.9 (95% CI 1.21%-2.98%). The relationship between HSV-2 and HIV was particularly strong among females, among whom 86% were HSV-2 seropositive, 23% were HIV seropositive, and all HIV seropositives were also HSV-2 seropositive.

CONCLUSIONS

HSV-2 appears to be an important factor in sexual transmission of HIV among noninjecting cocaine and heroin users in New York City, especially among females. The estimated population attributable risk for HIV infection attributable to HSV-2 infection in this sample was 38%. Programs to manage HSV-2 infection should be developed as part of comprehensive HIV prevention for noninjecting drug users.

Authors+Show Affiliations

Baron Edmond de Rothschild Chemical Dependency Institute, Beth Israel Medical Center, New York, NY 10038, USA. dcdesjarla@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18049425

Citation

Des Jarlais, Don C., et al. "Herpes Simplex Virus-2 and HIV Among Noninjecting Drug Users in New York City." Sexually Transmitted Diseases, vol. 34, no. 11, 2007, pp. 923-7.
Des Jarlais DC, Hagan H, Arasteh K, et al. Herpes simplex virus-2 and HIV among noninjecting drug users in New York city. Sex Transm Dis. 2007;34(11):923-7.
Des Jarlais, D. C., Hagan, H., Arasteh, K., McKnight, C., Perlman, D., & Friedman, S. R. (2007). Herpes simplex virus-2 and HIV among noninjecting drug users in New York city. Sexually Transmitted Diseases, 34(11), 923-7.
Des Jarlais DC, et al. Herpes Simplex Virus-2 and HIV Among Noninjecting Drug Users in New York City. Sex Transm Dis. 2007;34(11):923-7. PubMed PMID: 18049425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Herpes simplex virus-2 and HIV among noninjecting drug users in New York city. AU - Des Jarlais,Don C, AU - Hagan,Holly, AU - Arasteh,Kamyar, AU - McKnight,Courtney, AU - Perlman,David, AU - Friedman,Samuel R, PY - 2007/12/1/pubmed PY - 2008/1/16/medline PY - 2007/12/1/entrez SP - 923 EP - 7 JF - Sexually transmitted diseases JO - Sex Transm Dis VL - 34 IS - 11 N2 - OBJECTIVE: To examine the relationship between herpes simplex virus 2 (HSV-2) seroprevalence and human immunodeficiency virus (HIV) seroprevalence among noninjecting heroin and cocaine users in New York City. METHODS: Four hundred sixty-two noninjecting cocaine and heroin users were recruited from a drug detoxification program in New York City. Smoking crack cocaine, intranasal use of heroin, and intranasal use of cocaine were the most common types of drug use. A structured interview was administered and a serum sample was collected for HIV and HSV testing. RESULTS: HIV prevalence was 19% (95% CI 15%-22%) and HSV-2 seroprevalence was 60% (95% CI 55%-64%). The adjusted risk ratio for the association between HSV-2 and HIV was 1.9 (95% CI 1.21%-2.98%). The relationship between HSV-2 and HIV was particularly strong among females, among whom 86% were HSV-2 seropositive, 23% were HIV seropositive, and all HIV seropositives were also HSV-2 seropositive. CONCLUSIONS: HSV-2 appears to be an important factor in sexual transmission of HIV among noninjecting cocaine and heroin users in New York City, especially among females. The estimated population attributable risk for HIV infection attributable to HSV-2 infection in this sample was 38%. Programs to manage HSV-2 infection should be developed as part of comprehensive HIV prevention for noninjecting drug users. SN - 0148-5717 UR - https://www.unboundmedicine.com/medline/citation/18049425/Herpes_simplex_virus_2_and_HIV_among_noninjecting_drug_users_in_New_York_city_ L2 - https://doi.org/10.1097/OLQ.0b013e3180ca9647 DB - PRIME DP - Unbound Medicine ER -