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Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat.
Med Sci Monit. 2007 Dec; 13(12):BR286-92.MS

Abstract

BACKGROUND

There is increasing evidence that complications related to diabetes are associated with increased oxidative stress. Curcumin, an active principle of turmeric, has several biological properties, including antioxidant activity. The protective effect of curcumin and turmeric on streptozotocin (STZ)-induced oxidative stress in various tissues of rats was studied.

MATERIAL/METHODS

Three-month-old Wistar-NIN rats were made diabetic by injecting STZ (35 mg/kg body weight) intraperitoneally and fed either only the AIN-93 diet or the AIN-93 diet containing 0.002% or 0.01% curcumin or 0.5% turmeric for a period of eight weeks. After eight weeks the levels of oxidative stress parameters and activity of antioxidant enzymes were determined in various tissues.

RESULTS

STZ-induced hyperglycemia resulted in increased lipid peroxidation and protein carbonyls in red blood cells and other tissues and altered antioxidant enzyme activities. Interestingly, feeding curcumin and turmeric to the diabetic rats controlled oxidative stress by inhibiting the increase in TBARS and protein carbonyls and reversing altered antioxidant enzyme activities without altering the hyperglycemic state in most of the tissues.

CONCLUSIONS

Turmeric and curcumin appear to be beneficial in preventing diabetes-induced oxidative stress in rats despite unaltered hyperglycemic status.

Authors+Show Affiliations

Department of Biochemistry, National Institute of Nutrition, Hyderabad, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18049430

Citation

Suryanarayana, Palla, et al. "Effect of Turmeric and Curcumin On Oxidative Stress and Antioxidant Enzymes in Streptozotocin-induced Diabetic Rat." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 13, no. 12, 2007, pp. BR286-92.
Suryanarayana P, Satyanarayana A, Balakrishna N, et al. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med Sci Monit. 2007;13(12):BR286-92.
Suryanarayana, P., Satyanarayana, A., Balakrishna, N., Kumar, P. U., & Reddy, G. B. (2007). Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 13(12), BR286-92.
Suryanarayana P, et al. Effect of Turmeric and Curcumin On Oxidative Stress and Antioxidant Enzymes in Streptozotocin-induced Diabetic Rat. Med Sci Monit. 2007;13(12):BR286-92. PubMed PMID: 18049430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. AU - Suryanarayana,Palla, AU - Satyanarayana,Alleboena, AU - Balakrishna,Nagalla, AU - Kumar,Putcha Uday, AU - Reddy,Geereddy Bhanuprakash, PY - 2007/12/1/pubmed PY - 2008/4/12/medline PY - 2007/12/1/entrez SP - BR286 EP - 92 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 13 IS - 12 N2 - BACKGROUND: There is increasing evidence that complications related to diabetes are associated with increased oxidative stress. Curcumin, an active principle of turmeric, has several biological properties, including antioxidant activity. The protective effect of curcumin and turmeric on streptozotocin (STZ)-induced oxidative stress in various tissues of rats was studied. MATERIAL/METHODS: Three-month-old Wistar-NIN rats were made diabetic by injecting STZ (35 mg/kg body weight) intraperitoneally and fed either only the AIN-93 diet or the AIN-93 diet containing 0.002% or 0.01% curcumin or 0.5% turmeric for a period of eight weeks. After eight weeks the levels of oxidative stress parameters and activity of antioxidant enzymes were determined in various tissues. RESULTS: STZ-induced hyperglycemia resulted in increased lipid peroxidation and protein carbonyls in red blood cells and other tissues and altered antioxidant enzyme activities. Interestingly, feeding curcumin and turmeric to the diabetic rats controlled oxidative stress by inhibiting the increase in TBARS and protein carbonyls and reversing altered antioxidant enzyme activities without altering the hyperglycemic state in most of the tissues. CONCLUSIONS: Turmeric and curcumin appear to be beneficial in preventing diabetes-induced oxidative stress in rats despite unaltered hyperglycemic status. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/18049430/Effect_of_turmeric_and_curcumin_on_oxidative_stress_and_antioxidant_enzymes_in_streptozotocin_induced_diabetic_rat_ DB - PRIME DP - Unbound Medicine ER -