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Characterization of the encephalitogenic immune response in a model of multiple sclerosis.
Eur J Immunol. 2008 Jan; 38(1):299-308.EJ

Abstract

Experimental autoimmune encephalomyelitis (EAE) can be actively induced with the extracellular domain of myelin oligodendrocyte glycoprotein (MOG 1-125). MOG-EAE closely mimics multiple sclerosis (MS) especially as far as demyelination, lesion formation and axonal pathology are concerned. MOG 91-108 is the encephalitogenic stretch within MOG 1-125 in two EAE-susceptible MHC congenic LEW rat strains [LEW.1AV1 (RT1(av1)) and LEW.1N (RT1(n))] and DA (RT1(av1)) rats. In LEW.1AV1 rats, disease could be induced with MOG 96-104 and to a lesser extent with MOG 98-106, whereas in LEW.1N rats, only MOG 98-106 was pathogenic. Both peptides bound well to their restricting MHC class II molecules, i.e., RT1.D(n) in the LEW.1N rat and RT1.B(a) in the LEW.1AV1 rat. TCR spectratyping of MOG 91-108 immunized LEW.1N, LEW.1AV1 and DA rats revealed that MHC class II determined the TCRBV preference of CNS infiltrating T cells. The data demonstrate that the most critical factor in inducing MS like pathology is presentation of autoantigenic peptides on MHC class II molecules resulting in demyelination and axonal pathology.

Authors+Show Affiliations

Experimental Neuroimmunology Laboratory, Hertie Institute for Clinical Brain Research, Department of General Neurology, University of Tübingen, Tübingen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18050272

Citation

de Graaf, Katrien L., et al. "Characterization of the Encephalitogenic Immune Response in a Model of Multiple Sclerosis." European Journal of Immunology, vol. 38, no. 1, 2008, pp. 299-308.
de Graaf KL, Barth S, Herrmann MM, et al. Characterization of the encephalitogenic immune response in a model of multiple sclerosis. Eur J Immunol. 2008;38(1):299-308.
de Graaf, K. L., Barth, S., Herrmann, M. M., Storch, M. K., Wiesmüller, K. H., & Weissert, R. (2008). Characterization of the encephalitogenic immune response in a model of multiple sclerosis. European Journal of Immunology, 38(1), 299-308.
de Graaf KL, et al. Characterization of the Encephalitogenic Immune Response in a Model of Multiple Sclerosis. Eur J Immunol. 2008;38(1):299-308. PubMed PMID: 18050272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of the encephalitogenic immune response in a model of multiple sclerosis. AU - de Graaf,Katrien L, AU - Barth,Silvia, AU - Herrmann,Martin M, AU - Storch,Maria K, AU - Wiesmüller,Karl-Heinz, AU - Weissert,Robert, PY - 2007/12/1/pubmed PY - 2008/3/14/medline PY - 2007/12/1/entrez SP - 299 EP - 308 JF - European journal of immunology JO - Eur J Immunol VL - 38 IS - 1 N2 - Experimental autoimmune encephalomyelitis (EAE) can be actively induced with the extracellular domain of myelin oligodendrocyte glycoprotein (MOG 1-125). MOG-EAE closely mimics multiple sclerosis (MS) especially as far as demyelination, lesion formation and axonal pathology are concerned. MOG 91-108 is the encephalitogenic stretch within MOG 1-125 in two EAE-susceptible MHC congenic LEW rat strains [LEW.1AV1 (RT1(av1)) and LEW.1N (RT1(n))] and DA (RT1(av1)) rats. In LEW.1AV1 rats, disease could be induced with MOG 96-104 and to a lesser extent with MOG 98-106, whereas in LEW.1N rats, only MOG 98-106 was pathogenic. Both peptides bound well to their restricting MHC class II molecules, i.e., RT1.D(n) in the LEW.1N rat and RT1.B(a) in the LEW.1AV1 rat. TCR spectratyping of MOG 91-108 immunized LEW.1N, LEW.1AV1 and DA rats revealed that MHC class II determined the TCRBV preference of CNS infiltrating T cells. The data demonstrate that the most critical factor in inducing MS like pathology is presentation of autoantigenic peptides on MHC class II molecules resulting in demyelination and axonal pathology. SN - 0014-2980 UR - https://www.unboundmedicine.com/medline/citation/18050272/Characterization_of_the_encephalitogenic_immune_response_in_a_model_of_multiple_sclerosis_ L2 - https://doi.org/10.1002/eji.200737475 DB - PRIME DP - Unbound Medicine ER -