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[Evaluation of bronchial hyperreactivity in children with asthma undergoing food challenges].

Abstract

It has been shown that food allergy does not always manifest within the respiratory tract in such as obvious way as: dyspnea, cough or wheezing. The aim of the study was to evaluate the influence of food allergens on bronchial reactivity in children with asthma challenged with food.

MATERIALS AND METHODS

A total of 304 patients (age range 5.5 to 18 years, mean 9.5 +/- 4.69 years) with atopic asthma were evaluated for food allergy by means of questionnaire, skin prick testing with food allergens, specific IgE tests (Unicap 100) and double-blind placebo-controlled food challenge (DBPCFC). Bronchial hyperreactivity was measured by methacholine inhalation challenges performed before and after DBPCFC in 70 asthmatic patients suspected of food allergy.

RESULTS

IgE-related food allergy was confirmed by DBPCFC in 24 asthmatic children. The mean FEV1 before and after food challenges in the group with IgE-related food allergy, as well as in the group without IgE-related food allergy, was not significantly different (p > 0.05). The mean PC20 in IgE-related food allergy group was 1.41 +/- 1.12 mg/ml and 0.86 +/- 0.71 mg/ml before and after food challenge respectively which was significantly different (p < 0.05). In the group without IgE-related food allergy the mean PC20 was 1.93 +/- 1.68 and 2.02 +/- 1.75 before and after challenge respectively (p > 0.05).

CONCLUSIONS

IgE-related food allergy was present in 9.8% children with asthma. Prevalence of respiratory manifestations induced by foods in children with asthma is 4.1%. Food challenges in these children increased bronchial reactivity, without exacerbation. Evaluation of food allergy in patients with asthma is indicated.

Authors+Show Affiliations

,

Department of Allergology, Gastroenterology and Feeding of Children, Medical University of Łódź, Poland. anetkrog@poczta.onet.pl

,

Source

MeSH

Adolescent
Allergens
Asthma
Bronchial Hyperreactivity
Bronchial Provocation Tests
Child
Child, Preschool
Double-Blind Method
Female
Food Hypersensitivity
Humans
Immunoglobulin E
Male
Skin Tests
Spirometry

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial

Language

pol

PubMed ID

18051826

Citation

Krogulska, Aneta, et al. "[Evaluation of Bronchial Hyperreactivity in Children With Asthma Undergoing Food Challenges]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 23, no. 133, 2007, pp. 30-5.
Krogulska A, Wasowska-Królikowska K, Dynowski J. [Evaluation of bronchial hyperreactivity in children with asthma undergoing food challenges]. Pol Merkur Lekarski. 2007;23(133):30-5.
Krogulska, A., Wasowska-Królikowska, K., & Dynowski, J. (2007). [Evaluation of bronchial hyperreactivity in children with asthma undergoing food challenges]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 23(133), pp. 30-5.
Krogulska A, Wasowska-Królikowska K, Dynowski J. [Evaluation of Bronchial Hyperreactivity in Children With Asthma Undergoing Food Challenges]. Pol Merkur Lekarski. 2007;23(133):30-5. PubMed PMID: 18051826.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Evaluation of bronchial hyperreactivity in children with asthma undergoing food challenges]. AU - Krogulska,Aneta, AU - Wasowska-Królikowska,Krystyna, AU - Dynowski,Jarosław, PY - 2007/12/7/pubmed PY - 2008/1/26/medline PY - 2007/12/7/entrez SP - 30 EP - 5 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 23 IS - 133 N2 - UNLABELLED: It has been shown that food allergy does not always manifest within the respiratory tract in such as obvious way as: dyspnea, cough or wheezing. The aim of the study was to evaluate the influence of food allergens on bronchial reactivity in children with asthma challenged with food. MATERIALS AND METHODS: A total of 304 patients (age range 5.5 to 18 years, mean 9.5 +/- 4.69 years) with atopic asthma were evaluated for food allergy by means of questionnaire, skin prick testing with food allergens, specific IgE tests (Unicap 100) and double-blind placebo-controlled food challenge (DBPCFC). Bronchial hyperreactivity was measured by methacholine inhalation challenges performed before and after DBPCFC in 70 asthmatic patients suspected of food allergy. RESULTS: IgE-related food allergy was confirmed by DBPCFC in 24 asthmatic children. The mean FEV1 before and after food challenges in the group with IgE-related food allergy, as well as in the group without IgE-related food allergy, was not significantly different (p > 0.05). The mean PC20 in IgE-related food allergy group was 1.41 +/- 1.12 mg/ml and 0.86 +/- 0.71 mg/ml before and after food challenge respectively which was significantly different (p < 0.05). In the group without IgE-related food allergy the mean PC20 was 1.93 +/- 1.68 and 2.02 +/- 1.75 before and after challenge respectively (p > 0.05). CONCLUSIONS: IgE-related food allergy was present in 9.8% children with asthma. Prevalence of respiratory manifestations induced by foods in children with asthma is 4.1%. Food challenges in these children increased bronchial reactivity, without exacerbation. Evaluation of food allergy in patients with asthma is indicated. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/18051826/[Evaluation_of_bronchial_hyperreactivity_in_children_with_asthma_undergoing_food_challenges]_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -