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Oxidative stress and neurotoxicity.
Chem Res Toxicol. 2008 Jan; 21(1):172-88.CR

Abstract

There is increasing awareness of the ubiquitous role of oxidative stress in neurodegenerative disease states. A continuing challenge is to be able to distinguish between oxidative changes that occur early in the disease from those that are secondary manifestations of neuronal degeneration. This perspective highlights the role of oxidative stress in Alzheimer's, Parkinson's, and Huntington's diseases, amyotrophic lateral sclerosis, and multiple sclerosis, neurodegenerative and neuroinflammatory disorders where there is evidence for a primary contribution of oxidative stress in neuronal death, as opposed to other diseases where oxidative stress more likely plays a secondary or by-stander role. We begin with a brief review of the biochemistry of oxidative stress as it relates to mechanisms that lead to cell death, and why the central nervous system is particularly susceptible to such mechanisms. Following a review of oxidative stress involvement in individual disease states, some conclusions are provided as to what further research should hope to accomplish in the field.

Authors+Show Affiliations

Sayre LM
Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA. LMS3@case.edu
Perry G
No affiliation info available
Smith MA
No affiliation info available

MeSH

Alzheimer DiseaseAmyotrophic Lateral SclerosisAnimalsCell DeathHumansHuntington DiseaseMultiple SclerosisNeurodegenerative DiseasesNeuronsNeurotoxicity SyndromesOxidative StressParkinson Disease

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18052107

Citation

Sayre, Lawrence M., et al. "Oxidative Stress and Neurotoxicity." Chemical Research in Toxicology, vol. 21, no. 1, 2008, pp. 172-88.
Sayre LM, Perry G, Smith MA. Oxidative stress and neurotoxicity. Chem Res Toxicol. 2008;21(1):172-88.
Sayre, L. M., Perry, G., & Smith, M. A. (2008). Oxidative stress and neurotoxicity. Chemical Research in Toxicology, 21(1), 172-88.
Sayre LM, Perry G, Smith MA. Oxidative Stress and Neurotoxicity. Chem Res Toxicol. 2008;21(1):172-88. PubMed PMID: 18052107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and neurotoxicity. AU - Sayre,Lawrence M, AU - Perry,George, AU - Smith,Mark A, Y1 - 2007/12/04/ PY - 2007/12/7/pubmed PY - 2008/3/12/medline PY - 2007/12/7/entrez SP - 172 EP - 88 JF - Chemical research in toxicology JO - Chem Res Toxicol VL - 21 IS - 1 N2 - There is increasing awareness of the ubiquitous role of oxidative stress in neurodegenerative disease states. A continuing challenge is to be able to distinguish between oxidative changes that occur early in the disease from those that are secondary manifestations of neuronal degeneration. This perspective highlights the role of oxidative stress in Alzheimer's, Parkinson's, and Huntington's diseases, amyotrophic lateral sclerosis, and multiple sclerosis, neurodegenerative and neuroinflammatory disorders where there is evidence for a primary contribution of oxidative stress in neuronal death, as opposed to other diseases where oxidative stress more likely plays a secondary or by-stander role. We begin with a brief review of the biochemistry of oxidative stress as it relates to mechanisms that lead to cell death, and why the central nervous system is particularly susceptible to such mechanisms. Following a review of oxidative stress involvement in individual disease states, some conclusions are provided as to what further research should hope to accomplish in the field. SN - 0893-228X UR - https://www.unboundmedicine.com/medline/citation/18052107/Oxidative_stress_and_neurotoxicity_ DB - PRIME DP - Unbound Medicine ER -