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Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity.
J Nat Prod. 2007 Dec; 70(12):1915-8.JN

Abstract

The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine.

Authors+Show Affiliations

Suzuki K
Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan.
Okasaka M
No affiliation info available
Kashiwada Y
No affiliation info available
Takaishi Y
No affiliation info available
Honda G
No affiliation info available
Ito M
No affiliation info available
Takeda Y
No affiliation info available
Kodzhimatov OK
No affiliation info available
Ashurmetov O
No affiliation info available
Sekiya M
No affiliation info available
Ikeshiro Y
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicColchicineDrug Resistance, MultipleDrug Resistance, NeoplasmDrug Screening Assays, AntitumorFerulaHumansKB CellsLactonesMolecular StructurePlant RootsPlants, MedicinalSesquiterpenesUzbekistan

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18052129

Citation

Suzuki, Kyoko, et al. "Sesquiterpene Lactones From the Roots of Ferula Varia and Their Cytotoxic Activity." Journal of Natural Products, vol. 70, no. 12, 2007, pp. 1915-8.
Suzuki K, Okasaka M, Kashiwada Y, et al. Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity. J Nat Prod. 2007;70(12):1915-8.
Suzuki, K., Okasaka, M., Kashiwada, Y., Takaishi, Y., Honda, G., Ito, M., Takeda, Y., Kodzhimatov, O. K., Ashurmetov, O., Sekiya, M., & Ikeshiro, Y. (2007). Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity. Journal of Natural Products, 70(12), 1915-8.
Suzuki K, et al. Sesquiterpene Lactones From the Roots of Ferula Varia and Their Cytotoxic Activity. J Nat Prod. 2007;70(12):1915-8. PubMed PMID: 18052129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sesquiterpene lactones from the roots of Ferula varia and their cytotoxic activity. AU - Suzuki,Kyoko, AU - Okasaka,Mamoru, AU - Kashiwada,Yoshiki, AU - Takaishi,Yoshihisa, AU - Honda,Gisho, AU - Ito,Michiho, AU - Takeda,Yoshio, AU - Kodzhimatov,Olimjon K, AU - Ashurmetov,Ozodbek, AU - Sekiya,Michiko, AU - Ikeshiro,Yasumasa, Y1 - 2007/12/04/ PY - 2007/12/7/pubmed PY - 2008/3/7/medline PY - 2007/12/7/entrez SP - 1915 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 70 IS - 12 N2 - The ethyl acetate-soluble fraction from a MeOH extract of the roots of Ferula varia gave six new sesquiterpene lactones (1-6) and five known sesquiterpenes (7-11). Their structures were established on the basis of spectroscopic evidence. The cytotoxic activities of 1-11 were evaluated against selected human cancer cell lines. Compound 4 showed significant selective cytotoxicity against multidrug-resistant cancer cells (KB-C2). The cytotoxicities of compounds 1, 3, 5, 8, and 11 against KB-C2 cells were enhanced in the presence of nontoxic concentrations of colchicine. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/18052129/Sesquiterpene_lactones_from_the_roots_of_Ferula_varia_and_their_cytotoxic_activity_ DB - PRIME DP - Unbound Medicine ER -