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Fish oil fatty acids improve postprandial vascular reactivity in healthy men.
Clin Sci (Lond). 2008 Jun; 114(11):679-86.CS

Abstract

Chronic fish oil intervention had been shown to have a positive impact on endothelial function. Although high-fat meals have often been associated with a loss of postprandial vascular reactivity, studies examining the effects of fish oil fatty acids on vascular function in the postprandial phase are limited. The aim of the present study was to examine the impact of the addition of fish oil fatty acids to a standard test meal on postprandial vascular reactivity. A total of 25 men received in a random order either a placebo oil meal (40 g of mixed fat; fatty acid profile representative of the U.K. diet) or a fish oil meal (31 g of mixed fat and 9 g of fish oil) on two occasions. Vascular reactivity was measured at baseline (0 h) and 4 h after the meal by laser Doppler iontophoresis, and blood samples were taken for the measurement of plasma lipids, total nitrite, glucose and insulin. eNOS (endothelial NO synthase) and NADPH oxidase gene expression were determined in endothelial cells after incubation with TRLs (triacylglycerol-rich lipoproteins) isolated from the plasma samples taken at 4 h. Compared with baseline, sodium nitroprusside (an endothelium-independent vasodilator)-induced reactivity (P=0.024) and plasma nitrite levels (P=0.001) were increased after the fish oil meal. In endothelial cells, postprandial TRLs isolated after the fish oil meal increased eNOS and decreased NADPH oxidase gene expression compared with TRLs isolated following the placebo oil meal (P</=0.03). In conclusion, meal fatty acids appear to be an important determinant of vascular reactivity, with fish oils significantly improving postprandial endothelium-independent vasodilation.

Authors+Show Affiliations

Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, University of Reading, Reading RG6 6AP, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18052925

Citation

Armah, Christopher K., et al. "Fish Oil Fatty Acids Improve Postprandial Vascular Reactivity in Healthy Men." Clinical Science (London, England : 1979), vol. 114, no. 11, 2008, pp. 679-86.
Armah CK, Jackson KG, Doman I, et al. Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clin Sci. 2008;114(11):679-86.
Armah, C. K., Jackson, K. G., Doman, I., James, L., Cheghani, F., & Minihane, A. M. (2008). Fish oil fatty acids improve postprandial vascular reactivity in healthy men. Clinical Science (London, England : 1979), 114(11), 679-86.
Armah CK, et al. Fish Oil Fatty Acids Improve Postprandial Vascular Reactivity in Healthy Men. Clin Sci. 2008;114(11):679-86. PubMed PMID: 18052925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fish oil fatty acids improve postprandial vascular reactivity in healthy men. AU - Armah,Christopher K, AU - Jackson,Kim G, AU - Doman,Izzy, AU - James,Lewis, AU - Cheghani,Farah, AU - Minihane,Anne M, PY - 2007/12/7/pubmed PY - 2008/5/31/medline PY - 2007/12/7/entrez SP - 679 EP - 86 JF - Clinical science (London, England : 1979) JO - Clin. Sci. VL - 114 IS - 11 N2 - Chronic fish oil intervention had been shown to have a positive impact on endothelial function. Although high-fat meals have often been associated with a loss of postprandial vascular reactivity, studies examining the effects of fish oil fatty acids on vascular function in the postprandial phase are limited. The aim of the present study was to examine the impact of the addition of fish oil fatty acids to a standard test meal on postprandial vascular reactivity. A total of 25 men received in a random order either a placebo oil meal (40 g of mixed fat; fatty acid profile representative of the U.K. diet) or a fish oil meal (31 g of mixed fat and 9 g of fish oil) on two occasions. Vascular reactivity was measured at baseline (0 h) and 4 h after the meal by laser Doppler iontophoresis, and blood samples were taken for the measurement of plasma lipids, total nitrite, glucose and insulin. eNOS (endothelial NO synthase) and NADPH oxidase gene expression were determined in endothelial cells after incubation with TRLs (triacylglycerol-rich lipoproteins) isolated from the plasma samples taken at 4 h. Compared with baseline, sodium nitroprusside (an endothelium-independent vasodilator)-induced reactivity (P=0.024) and plasma nitrite levels (P=0.001) were increased after the fish oil meal. In endothelial cells, postprandial TRLs isolated after the fish oil meal increased eNOS and decreased NADPH oxidase gene expression compared with TRLs isolated following the placebo oil meal (P</=0.03). In conclusion, meal fatty acids appear to be an important determinant of vascular reactivity, with fish oils significantly improving postprandial endothelium-independent vasodilation. SN - 1470-8736 UR - https://www.unboundmedicine.com/medline/citation/18052925/Fish_oil_fatty_acids_improve_postprandial_vascular_reactivity_in_healthy_men_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/CS20070277 DB - PRIME DP - Unbound Medicine ER -