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Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease.
Neurosci Res. 2008 Feb; 60(2):156-61.NR

Abstract

Emerging evidence suggests beneficial effects of estrogen and estrogen-like chemicals on neurodegenerative diseases, especially Parkinson's disease (PD). Genistein, an isoflavone naturally found in soy products, displays estrogenic properties. The present study aims to investigate the neuroprotective effects of genistein on dopaminergic neurons in ovariectomized (OVX), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model mice. MPTP significantly decreased the levels of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum, which could be restored by genistein or estrogen pretreatment. MPTP-challenge with genistein or estrogen pretreatment demonstrated reduced neurotoxicity, with tyrosine hydroxylase-immunoreactive (TH-IR) neurons in the substantia nigra pars compacta (SNpc) affected to a significantly lesser extent as compared to the MPTP treated control. The reverse transcription-PCR results also confirmed that the MPTP-induced downregulation of TH, dopamine transporter (DAT) and Bcl-2 mRNA expression in the midbrain could be restored by genistein or estrogen pretreatment. These findings provide the first evidence that genistein has neuroprotective effects on dopaminergic neurons in the MPTP-induced PD mice and this effect may be attributed to enhancing Bcl-2 gene expression.

Authors+Show Affiliations

Department of Physiology, Medical College of Qingdao University, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18054104

Citation

Liu, Li-Xing, et al. "Neuroprotective Effects of Genistein On Dopaminergic Neurons in the Mice Model of Parkinson's Disease." Neuroscience Research, vol. 60, no. 2, 2008, pp. 156-61.
Liu LX, Chen WF, Xie JX, et al. Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease. Neurosci Res. 2008;60(2):156-61.
Liu, L. X., Chen, W. F., Xie, J. X., & Wong, M. S. (2008). Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease. Neuroscience Research, 60(2), 156-61.
Liu LX, et al. Neuroprotective Effects of Genistein On Dopaminergic Neurons in the Mice Model of Parkinson's Disease. Neurosci Res. 2008;60(2):156-61. PubMed PMID: 18054104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of genistein on dopaminergic neurons in the mice model of Parkinson's disease. AU - Liu,Li-Xing, AU - Chen,Wen-Fang, AU - Xie,Jun-Xia, AU - Wong,Man-Sau, Y1 - 2007/10/23/ PY - 2007/08/20/received PY - 2007/10/01/revised PY - 2007/10/16/accepted PY - 2007/12/7/pubmed PY - 2008/4/19/medline PY - 2007/12/7/entrez SP - 156 EP - 61 JF - Neuroscience research JO - Neurosci Res VL - 60 IS - 2 N2 - Emerging evidence suggests beneficial effects of estrogen and estrogen-like chemicals on neurodegenerative diseases, especially Parkinson's disease (PD). Genistein, an isoflavone naturally found in soy products, displays estrogenic properties. The present study aims to investigate the neuroprotective effects of genistein on dopaminergic neurons in ovariectomized (OVX), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model mice. MPTP significantly decreased the levels of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the striatum, which could be restored by genistein or estrogen pretreatment. MPTP-challenge with genistein or estrogen pretreatment demonstrated reduced neurotoxicity, with tyrosine hydroxylase-immunoreactive (TH-IR) neurons in the substantia nigra pars compacta (SNpc) affected to a significantly lesser extent as compared to the MPTP treated control. The reverse transcription-PCR results also confirmed that the MPTP-induced downregulation of TH, dopamine transporter (DAT) and Bcl-2 mRNA expression in the midbrain could be restored by genistein or estrogen pretreatment. These findings provide the first evidence that genistein has neuroprotective effects on dopaminergic neurons in the MPTP-induced PD mice and this effect may be attributed to enhancing Bcl-2 gene expression. SN - 0168-0102 UR - https://www.unboundmedicine.com/medline/citation/18054104/Neuroprotective_effects_of_genistein_on_dopaminergic_neurons_in_the_mice_model_of_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-0102(07)01816-0 DB - PRIME DP - Unbound Medicine ER -