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Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why?

Abstract

Low blood folate and raised homocysteine concentrations are associated with poor cognitive function. Folic acid supplementation improves cognitive function. Folic acid enhances the plasma concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). EPA, DHA, and arachidonic acid (AA) are of benefit in dementia and Alzheimer's disease by up-regulating gene expression concerned with neurogenesis, neurotransmission and connectivity, improving endothelial nitric oxide (eNO) generation, enhancing brain acetylcholine levels, and suppressing the production of pro-inflammatory cytokines. EPA, DHA, and AA also form precursors to anti-inflammatory compounds such as lipoxins, resolvins, and neuroprotectin D1 (NPD1) that protect neurons from the cytotoxic action of various noxious stimuli. Furthermore, various neurotrophins and statins enhance the formation of NPD1 and thus, protect neurons from oxidative stress and prevent neuronal apoptosis Folic acid improves eNO generation, enhances plasma levels of EPA/DHA and thus, could augment the formation of NPD1. These results suggest that a combination of EPA, DHA, AA and folic acid could be of significant benefit in dementia, depression, and Alzheimer's disease and improve cognitive function.

Authors+Show Affiliations

UND Life Sciences, 13800 Fairhill Road #321, Shaker Heights, OH 44120, USA. undurti@hotmail.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18054217

Citation

Das, Undurti N.. "Folic Acid and Polyunsaturated Fatty Acids Improve Cognitive Function and Prevent Depression, Dementia, and Alzheimer's Disease--but How and Why?" Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 78, no. 1, 2008, pp. 11-9.
Das UN. Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why? Prostaglandins Leukot Essent Fatty Acids. 2008;78(1):11-9.
Das, U. N. (2008). Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why? Prostaglandins, Leukotrienes, and Essential Fatty Acids, 78(1), 11-9.
Das UN. Folic Acid and Polyunsaturated Fatty Acids Improve Cognitive Function and Prevent Depression, Dementia, and Alzheimer's Disease--but How and Why. Prostaglandins Leukot Essent Fatty Acids. 2008;78(1):11-9. PubMed PMID: 18054217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease--but how and why? A1 - Das,Undurti N, Y1 - 2007/11/28/ PY - 2007/03/23/received PY - 2007/08/18/revised PY - 2007/10/21/accepted PY - 2007/12/7/pubmed PY - 2008/3/21/medline PY - 2007/12/7/entrez SP - 11 EP - 9 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 78 IS - 1 N2 - Low blood folate and raised homocysteine concentrations are associated with poor cognitive function. Folic acid supplementation improves cognitive function. Folic acid enhances the plasma concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). EPA, DHA, and arachidonic acid (AA) are of benefit in dementia and Alzheimer's disease by up-regulating gene expression concerned with neurogenesis, neurotransmission and connectivity, improving endothelial nitric oxide (eNO) generation, enhancing brain acetylcholine levels, and suppressing the production of pro-inflammatory cytokines. EPA, DHA, and AA also form precursors to anti-inflammatory compounds such as lipoxins, resolvins, and neuroprotectin D1 (NPD1) that protect neurons from the cytotoxic action of various noxious stimuli. Furthermore, various neurotrophins and statins enhance the formation of NPD1 and thus, protect neurons from oxidative stress and prevent neuronal apoptosis Folic acid improves eNO generation, enhances plasma levels of EPA/DHA and thus, could augment the formation of NPD1. These results suggest that a combination of EPA, DHA, AA and folic acid could be of significant benefit in dementia, depression, and Alzheimer's disease and improve cognitive function. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/18054217/Folic_acid_and_polyunsaturated_fatty_acids_improve_cognitive_function_and_prevent_depression_dementia_and_Alzheimer's_disease__but_how_and_why L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(07)00135-4 DB - PRIME DP - Unbound Medicine ER -