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Effects of iron supplementation on attention deficit hyperactivity disorder in children.

Abstract

Iron deficiency has been suggested as a possible contributing cause of attention deficit hyperactivity disorder (ADHD) in children. This present study examined the effects of iron supplementation on ADHD in children. Twenty-three nonanemic children (aged 5-8 years) with serum ferritin levels <30 ng/mL who met DSM-IV criteria for ADHD were randomized (3:1 ratio) to either oral iron (ferrous sulfate, 80 mg/day, n = 18) or placebo (n = 5) for 12 weeks. There was a progressive significant decrease in the ADHD Rating Scale after 12 weeks on iron (-11.0 +/- 13.9; P < 0.008), but not on placebo (3.0 +/- 5.7; P = 0.308). Improvement on Conners' Parent Rating Scale (P = 0.055) and Conners' Teacher Rating Scale (P = 0.076) with iron supplementation therapy failed to reach significance. The mean Clinical Global Impression-Severity significantly decreased at 12 weeks (P < 0.01) with iron, without change in the placebo group. Iron supplementation (80 mg/day) appeared to improve ADHD symptoms in children with low serum ferritin levels suggesting a need for future investigations with larger controlled trials. Iron therapy was well tolerated and effectiveness is comparable to stimulants.

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  • Authors+Show Affiliations

    ,

    Hôpital Robert Debré, Service de Psychopathologie de l'Enfant et de l'Adolescent, Paris, France. eric.konofal@rdb.aphp.fr

    , , , , , ,

    Source

    Pediatric neurology 38:1 2008 Jan pg 20-6

    MeSH

    Attention Deficit Disorder with Hyperactivity
    Biomarkers
    Caregivers
    Child
    Child, Preschool
    Dietary Supplements
    Disability Evaluation
    Double-Blind Method
    Female
    Ferritins
    Ferrous Compounds
    Humans
    Iron
    Male
    Parents
    Pilot Projects
    Placebos
    Restless Legs Syndrome
    Surveys and Questionnaires
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    18054688

    Citation

    Konofal, Eric, et al. "Effects of Iron Supplementation On Attention Deficit Hyperactivity Disorder in Children." Pediatric Neurology, vol. 38, no. 1, 2008, pp. 20-6.
    Konofal E, Lecendreux M, Deron J, et al. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol. 2008;38(1):20-6.
    Konofal, E., Lecendreux, M., Deron, J., Marchand, M., Cortese, S., Zaïm, M., ... Arnulf, I. (2008). Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatric Neurology, 38(1), pp. 20-6.
    Konofal E, et al. Effects of Iron Supplementation On Attention Deficit Hyperactivity Disorder in Children. Pediatr Neurol. 2008;38(1):20-6. PubMed PMID: 18054688.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of iron supplementation on attention deficit hyperactivity disorder in children. AU - Konofal,Eric, AU - Lecendreux,Michel, AU - Deron,Juliette, AU - Marchand,Martine, AU - Cortese,Samuele, AU - Zaïm,Mohammed, AU - Mouren,Marie Christine, AU - Arnulf,Isabelle, PY - 2007/06/12/received PY - 2007/07/03/revised PY - 2007/08/16/accepted PY - 2007/12/7/pubmed PY - 2008/2/20/medline PY - 2007/12/7/entrez SP - 20 EP - 6 JF - Pediatric neurology JO - Pediatr. Neurol. VL - 38 IS - 1 N2 - Iron deficiency has been suggested as a possible contributing cause of attention deficit hyperactivity disorder (ADHD) in children. This present study examined the effects of iron supplementation on ADHD in children. Twenty-three nonanemic children (aged 5-8 years) with serum ferritin levels <30 ng/mL who met DSM-IV criteria for ADHD were randomized (3:1 ratio) to either oral iron (ferrous sulfate, 80 mg/day, n = 18) or placebo (n = 5) for 12 weeks. There was a progressive significant decrease in the ADHD Rating Scale after 12 weeks on iron (-11.0 +/- 13.9; P < 0.008), but not on placebo (3.0 +/- 5.7; P = 0.308). Improvement on Conners' Parent Rating Scale (P = 0.055) and Conners' Teacher Rating Scale (P = 0.076) with iron supplementation therapy failed to reach significance. The mean Clinical Global Impression-Severity significantly decreased at 12 weeks (P < 0.01) with iron, without change in the placebo group. Iron supplementation (80 mg/day) appeared to improve ADHD symptoms in children with low serum ferritin levels suggesting a need for future investigations with larger controlled trials. Iron therapy was well tolerated and effectiveness is comparable to stimulants. SN - 0887-8994 UR - https://www.unboundmedicine.com/medline/citation/18054688/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0887-8994(07)00417-1 DB - PRIME DP - Unbound Medicine ER -