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Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial.
Fertil Steril 2008; 90(1):113-20FS

Abstract

OBJECTIVE

To evaluate the effectiveness of a GnRH antagonist in preventing premature LH surge under a letrozole and gonadotropin protocol.

DESIGN

Prospective, randomized clinical trial.

SETTING

A teaching hospital and tertiary medical center.

PATIENT(S)

Sixty-one patients were randomly assigned into two letrozole and gonadotropin-treated groups. These were distinguished by the absence (group I) or presence (group II) of supplementation with 0.25 mg of cetrorelix.

INTERVENTION(S)

Controlled ovarian stimulation with letrozole and gonadotropins, cetrorelix and intrauterine insemination.

MAIN OUTCOME MEASURE(S)

Rate of premature LH surge.

RESULT(S)

Compared with group I, the rate of premature LH surge was statistically significantly lower for group II (43.4% [13/30] vs. 19.4% [6/31]), but the amount of gonadotropins used was statistically significantly higher (817.5 +/- 28.5 vs. 907.5 +/- 27.3 IU). Patients with premature LH surge had a statistically significantly lower pregnancy rate (21.4% [9/42] vs. 0 [0/18]) relative to their unaffected counterparts.

CONCLUSION(S)

A flexible protocol of 0.25 mg of cetrorelix for IUI cycles appears to suppress the rate of premature LH surge during ovarian stimulation with letrozole and gonadotropins. However, the incidence of premature LH surge remains too high, and modification will be necessary before the application of cetrorelix to IVF treatment.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, National Taiwan University Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18054932

Citation

Lee, Tsung-Hsien, et al. "Effectiveness of Cetrorelix for the Prevention of Premature Luteinizing Hormone Surge During Controlled Ovarian Stimulation Using Letrozole and Gonadotropins: a Randomized Trial." Fertility and Sterility, vol. 90, no. 1, 2008, pp. 113-20.
Lee TH, Lin YH, Seow KM, et al. Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial. Fertil Steril. 2008;90(1):113-20.
Lee, T. H., Lin, Y. H., Seow, K. M., Hwang, J. L., Tzeng, C. R., & Yang, Y. S. (2008). Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial. Fertility and Sterility, 90(1), pp. 113-20.
Lee TH, et al. Effectiveness of Cetrorelix for the Prevention of Premature Luteinizing Hormone Surge During Controlled Ovarian Stimulation Using Letrozole and Gonadotropins: a Randomized Trial. Fertil Steril. 2008;90(1):113-20. PubMed PMID: 18054932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of cetrorelix for the prevention of premature luteinizing hormone surge during controlled ovarian stimulation using letrozole and gonadotropins: a randomized trial. AU - Lee,Tsung-Hsien, AU - Lin,Yu-Hung, AU - Seow,Kok-Min, AU - Hwang,Jiann-Loung, AU - Tzeng,Chii-Ruey, AU - Yang,Yu-Shih, Y1 - 2007/12/11/ PY - 2007/04/11/received PY - 2007/06/06/revised PY - 2007/06/06/accepted PY - 2007/12/7/pubmed PY - 2008/7/18/medline PY - 2007/12/7/entrez SP - 113 EP - 20 JF - Fertility and sterility JO - Fertil. Steril. VL - 90 IS - 1 N2 - OBJECTIVE: To evaluate the effectiveness of a GnRH antagonist in preventing premature LH surge under a letrozole and gonadotropin protocol. DESIGN: Prospective, randomized clinical trial. SETTING: A teaching hospital and tertiary medical center. PATIENT(S): Sixty-one patients were randomly assigned into two letrozole and gonadotropin-treated groups. These were distinguished by the absence (group I) or presence (group II) of supplementation with 0.25 mg of cetrorelix. INTERVENTION(S): Controlled ovarian stimulation with letrozole and gonadotropins, cetrorelix and intrauterine insemination. MAIN OUTCOME MEASURE(S): Rate of premature LH surge. RESULT(S): Compared with group I, the rate of premature LH surge was statistically significantly lower for group II (43.4% [13/30] vs. 19.4% [6/31]), but the amount of gonadotropins used was statistically significantly higher (817.5 +/- 28.5 vs. 907.5 +/- 27.3 IU). Patients with premature LH surge had a statistically significantly lower pregnancy rate (21.4% [9/42] vs. 0 [0/18]) relative to their unaffected counterparts. CONCLUSION(S): A flexible protocol of 0.25 mg of cetrorelix for IUI cycles appears to suppress the rate of premature LH surge during ovarian stimulation with letrozole and gonadotropins. However, the incidence of premature LH surge remains too high, and modification will be necessary before the application of cetrorelix to IVF treatment. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18054932/Effectiveness_of_cetrorelix_for_the_prevention_of_premature_luteinizing_hormone_surge_during_controlled_ovarian_stimulation_using_letrozole_and_gonadotropins:_a_randomized_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)01373-8 DB - PRIME DP - Unbound Medicine ER -