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Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve.
Fertil Steril. 2008 Nov; 90(5):1579-82.FS

Abstract

OBJECTIVE

To evaluate whether methotrexate (MTX) compromises ovarian reserve and future reproductive outcome in women undergoing assisted reproductive technology (ART), when it is used as first-line treatment for ectopic pregnancy (EP).

DESIGN

Prospective, observational study.

SETTING

University-affiliated private IVF unit.

PATIENT(S)

Twenty-five women undergoing IVF-ICSI who were treated with MTX (1 mg/kg IM) for an EP after ART.

INTERVENTION(S)

Evaluation of reproductive outcome and serum anti-Müllerian hormone (AMH) levels. Serum AMH was evaluated before administering MTX and >or=1 week after the resolution of the EP. Reproductive outcome was evaluated by comparing subsequent IVF-ICSI cycles after EP resolution.

MAIN OUTCOME MEASURE(S)

Serum AMH levels, cycle length, gonadotropin dose required, peak serum E(2) level, oocytes collected, and embryos obtained.

RESULT(S)

Serum AMH levels before MTX were not statistically significantly different from those after treatment (3.7 +/- 0.3 ng/mL vs. 3.9 +/- 0.3 ng/mL). Patients undergoing a subsequent cycle after systemic treatment for EP had similar cycle durations (10.3 vs. 10.8 d), gonadotropin requirements (2,775 vs. 2,630.3 IU), peak E(2) levels (1,884.3 vs. 1,523.6 pg/mL), number of oocytes retrieved (12.1 vs. 10.5), and total number of embryos obtained (7.1 vs. 6.5).

CONCLUSION(S)

Single-dose MTX is a safe first-treatment choice that does not compromise future reproductive outcomes in women who are diagnosed with EP after ART.

Authors+Show Affiliations

IVI-Madrid, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18054933

Citation

Oriol, Bárbara, et al. "Systemic Methotrexate to Treat Ectopic Pregnancy Does Not Affect Ovarian Reserve." Fertility and Sterility, vol. 90, no. 5, 2008, pp. 1579-82.
Oriol B, Barrio A, Pacheco A, et al. Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve. Fertil Steril. 2008;90(5):1579-82.
Oriol, B., Barrio, A., Pacheco, A., Serna, J., Zuzuarregui, J. L., & Garcia-Velasco, J. A. (2008). Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve. Fertility and Sterility, 90(5), 1579-82.
Oriol B, et al. Systemic Methotrexate to Treat Ectopic Pregnancy Does Not Affect Ovarian Reserve. Fertil Steril. 2008;90(5):1579-82. PubMed PMID: 18054933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systemic methotrexate to treat ectopic pregnancy does not affect ovarian reserve. AU - Oriol,Bárbara, AU - Barrio,Ana, AU - Pacheco,Alberto, AU - Serna,José, AU - Zuzuarregui,José Luis, AU - Garcia-Velasco,Juan A, Y1 - 2007/12/11/ PY - 2007/06/08/received PY - 2007/08/13/revised PY - 2007/08/13/accepted PY - 2007/12/7/pubmed PY - 2008/12/17/medline PY - 2007/12/7/entrez SP - 1579 EP - 82 JF - Fertility and sterility JO - Fertil Steril VL - 90 IS - 5 N2 - OBJECTIVE: To evaluate whether methotrexate (MTX) compromises ovarian reserve and future reproductive outcome in women undergoing assisted reproductive technology (ART), when it is used as first-line treatment for ectopic pregnancy (EP). DESIGN: Prospective, observational study. SETTING: University-affiliated private IVF unit. PATIENT(S): Twenty-five women undergoing IVF-ICSI who were treated with MTX (1 mg/kg IM) for an EP after ART. INTERVENTION(S): Evaluation of reproductive outcome and serum anti-Müllerian hormone (AMH) levels. Serum AMH was evaluated before administering MTX and >or=1 week after the resolution of the EP. Reproductive outcome was evaluated by comparing subsequent IVF-ICSI cycles after EP resolution. MAIN OUTCOME MEASURE(S): Serum AMH levels, cycle length, gonadotropin dose required, peak serum E(2) level, oocytes collected, and embryos obtained. RESULT(S): Serum AMH levels before MTX were not statistically significantly different from those after treatment (3.7 +/- 0.3 ng/mL vs. 3.9 +/- 0.3 ng/mL). Patients undergoing a subsequent cycle after systemic treatment for EP had similar cycle durations (10.3 vs. 10.8 d), gonadotropin requirements (2,775 vs. 2,630.3 IU), peak E(2) levels (1,884.3 vs. 1,523.6 pg/mL), number of oocytes retrieved (12.1 vs. 10.5), and total number of embryos obtained (7.1 vs. 6.5). CONCLUSION(S): Single-dose MTX is a safe first-treatment choice that does not compromise future reproductive outcomes in women who are diagnosed with EP after ART. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18054933/Systemic_methotrexate_to_treat_ectopic_pregnancy_does_not_affect_ovarian_reserve_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)03175-5 DB - PRIME DP - Unbound Medicine ER -