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Lycopene attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain.
Eur J Pain. 2008 Jul; 12(5):624-32.EJ

Abstract

Diabetic neuropathic pain, an important microvascular complication of diabetes mellitus is recognized as one of the most difficult types of pain to treat. The development of tolerance, inadequate relief and potential toxicity of classical antinociceptives warrant the investigation of the newer agents to relieve this pain. The aim of the present study was to explore the antinociceptive effect of lycopene and its effect on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) release in streptozotocin induced diabetic mice. Four weeks after a single intraperitoneal injection of streptozotocin (200 mg/kg), mice were tested in the tail immersion and hot-plate assays. Diabetic mice exhibited significant hyperalgesia alongwith increased plasma glucose and decreased body weights as compared with control mice. Lycopene (1, 2 and 4 mg/kg body weight; per oral) treatment, from the 4th to 8th week after streptozotocin injection, significantly attenuated thermal hyperalgesia and the hot-plate latencies. Lycopene also inhibited the TNF-alpha and NO release in a dose dependent manner. These results indicate an antinociceptive activity of lycopene possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain.

Authors+Show Affiliations

Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh 160 014, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18055235

Citation

Kuhad, Anurag, et al. "Lycopene Attenuates Thermal Hyperalgesia in a Diabetic Mouse Model of Neuropathic Pain." European Journal of Pain (London, England), vol. 12, no. 5, 2008, pp. 624-32.
Kuhad A, Sharma S, Chopra K. Lycopene attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur J Pain. 2008;12(5):624-32.
Kuhad, A., Sharma, S., & Chopra, K. (2008). Lycopene attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. European Journal of Pain (London, England), 12(5), 624-32.
Kuhad A, Sharma S, Chopra K. Lycopene Attenuates Thermal Hyperalgesia in a Diabetic Mouse Model of Neuropathic Pain. Eur J Pain. 2008;12(5):624-32. PubMed PMID: 18055235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lycopene attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. AU - Kuhad,Anurag, AU - Sharma,Sameer, AU - Chopra,Kanwaljit, Y1 - 2007/12/04/ PY - 2007/05/18/received PY - 2007/10/18/revised PY - 2007/10/18/accepted PY - 2007/12/7/pubmed PY - 2008/9/27/medline PY - 2007/12/7/entrez SP - 624 EP - 32 JF - European journal of pain (London, England) JO - Eur J Pain VL - 12 IS - 5 N2 - Diabetic neuropathic pain, an important microvascular complication of diabetes mellitus is recognized as one of the most difficult types of pain to treat. The development of tolerance, inadequate relief and potential toxicity of classical antinociceptives warrant the investigation of the newer agents to relieve this pain. The aim of the present study was to explore the antinociceptive effect of lycopene and its effect on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) release in streptozotocin induced diabetic mice. Four weeks after a single intraperitoneal injection of streptozotocin (200 mg/kg), mice were tested in the tail immersion and hot-plate assays. Diabetic mice exhibited significant hyperalgesia alongwith increased plasma glucose and decreased body weights as compared with control mice. Lycopene (1, 2 and 4 mg/kg body weight; per oral) treatment, from the 4th to 8th week after streptozotocin injection, significantly attenuated thermal hyperalgesia and the hot-plate latencies. Lycopene also inhibited the TNF-alpha and NO release in a dose dependent manner. These results indicate an antinociceptive activity of lycopene possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain. SN - 1532-2149 UR - https://www.unboundmedicine.com/medline/citation/18055235/Lycopene_attenuates_thermal_hyperalgesia_in_a_diabetic_mouse_model_of_neuropathic_pain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-3801(07)00670-2 DB - PRIME DP - Unbound Medicine ER -