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Folate and vitamin B12 levels in levodopa-treated Parkinson's disease patients: their relationship to clinical manifestations, mood and cognition.
Parkinsonism Relat Disord. 2008; 14(4):321-5.PR

Abstract

We tested the hypothesis that mood, clinical manifestations and cognitive impairment of levodopa-treated Parkinson's disease (PD) patients are associated with vitamin B12 and folate deficiency. To this end, we performed this cross-sectional study by measuring serum folate and vitamin B12 blood levels in 111 consecutive PD patients. Levodopa-treated PD patients showed significantly lower serum levels of folate and vitamin B12 than neurological controls, while depressed patients had significantly lower serum folate levels as compared to non-depressed. Cognitively impaired PD patients exhibited significantly lower serum vitamin B12 levels as compared to cognitively non-impaired. In conclusion, lower folate levels were associated with depression, while lower vitamin B12 levels were associated with cognitive impairment. The effects of vitamin supplementation merit further attention and investigation.

Authors+Show Affiliations

Department of Neurology, Aeginition Hospital, Athens University Medical School, Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

18055246

Citation

Triantafyllou, Nikolaos I., et al. "Folate and Vitamin B12 Levels in Levodopa-treated Parkinson's Disease Patients: Their Relationship to Clinical Manifestations, Mood and Cognition." Parkinsonism & Related Disorders, vol. 14, no. 4, 2008, pp. 321-5.
Triantafyllou NI, Nikolaou C, Boufidou F, et al. Folate and vitamin B12 levels in levodopa-treated Parkinson's disease patients: their relationship to clinical manifestations, mood and cognition. Parkinsonism Relat Disord. 2008;14(4):321-5.
Triantafyllou, N. I., Nikolaou, C., Boufidou, F., Angelopoulos, E., Rentzos, M., Kararizou, E., Evangelopoulos, M. E., & Vassilopoulos, D. (2008). Folate and vitamin B12 levels in levodopa-treated Parkinson's disease patients: their relationship to clinical manifestations, mood and cognition. Parkinsonism & Related Disorders, 14(4), 321-5.
Triantafyllou NI, et al. Folate and Vitamin B12 Levels in Levodopa-treated Parkinson's Disease Patients: Their Relationship to Clinical Manifestations, Mood and Cognition. Parkinsonism Relat Disord. 2008;14(4):321-5. PubMed PMID: 18055246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate and vitamin B12 levels in levodopa-treated Parkinson's disease patients: their relationship to clinical manifestations, mood and cognition. AU - Triantafyllou,Nikolaos I, AU - Nikolaou,Chrysoula, AU - Boufidou,Fotini, AU - Angelopoulos,Elias, AU - Rentzos,Michael, AU - Kararizou,Evangelia, AU - Evangelopoulos,Maria-Eleftheria, AU - Vassilopoulos,Dimitrios, Y1 - 2007/12/04/ PY - 2006/03/03/received PY - 2007/08/21/revised PY - 2007/10/01/accepted PY - 2007/12/7/pubmed PY - 2008/10/9/medline PY - 2007/12/7/entrez SP - 321 EP - 5 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 14 IS - 4 N2 - We tested the hypothesis that mood, clinical manifestations and cognitive impairment of levodopa-treated Parkinson's disease (PD) patients are associated with vitamin B12 and folate deficiency. To this end, we performed this cross-sectional study by measuring serum folate and vitamin B12 blood levels in 111 consecutive PD patients. Levodopa-treated PD patients showed significantly lower serum levels of folate and vitamin B12 than neurological controls, while depressed patients had significantly lower serum folate levels as compared to non-depressed. Cognitively impaired PD patients exhibited significantly lower serum vitamin B12 levels as compared to cognitively non-impaired. In conclusion, lower folate levels were associated with depression, while lower vitamin B12 levels were associated with cognitive impairment. The effects of vitamin supplementation merit further attention and investigation. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/18055246/Folate_and_vitamin_B12_levels_in_levodopa_treated_Parkinson's_disease_patients:_their_relationship_to_clinical_manifestations_mood_and_cognition_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(07)00214-3 DB - PRIME DP - Unbound Medicine ER -