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Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter.
Am J Physiol Heart Circ Physiol 2008; 294(2):H605-12AJ

Abstract

The cardiovascular benefits of light to moderate red wine consumption often have been attributed to its polyphenol constituents. However, the acute dose-related hemodynamic, vasodilator, and sympathetic neural effects of ethanol and red wine have not been characterized and compared in the same individual. We sought to test the hypotheses that responses to one and two alcoholic drinks differ and that red wine with high polyphenol content elicits a greater effect than ethanol alone. Thirteen volunteers (24-47 yr; 7 men, 6 women) drank wine, ethanol, and water in a randomized, single-blind trial on three occasions 2 wk apart. One drink of wine and ethanol increased blood alcohol to 38 +/- 2 and 39 +/- 2 mg/dl, respectively, and two drinks to 72 +/- 4 and 83 +/- 3 mg/dl, respectively. Wine quadrupled plasma resveratrol (P < 0.001) and increased catechin (P < 0.03). No intervention affected blood pressure. One drink had no heart rate effect, but two drinks of wine increased heart rate by 5.7 +/- 1.6 beats/min; P < 0.001). Cardiac output fell 0.8 +/- 0.3 l/min after one drink of ethanol and wine (both P < 0.02) but increased after two drinks of ethanol (+0.8 +/- 0.3 l/min) and wine (+1.2 +/- 0.3 l/min) (P < 0.01). One alcoholic drink did not alter muscle sympathetic nerve activity (MSNA), while two drinks increased MSNA by 9-10 bursts/min (P < 0.001). Brachial artery diameter increased after both one and two alcoholic drinks (P < 0.001). No beverage augmented, and the second wine dose attenuated (P = 0.02), flow-mediated vasodilation. One drink of ethanol dilates the brachial artery without activating sympathetic outflow, whereas two drinks increase MSNA, heart rate, and cardiac output. These acute effects, which exhibit a narrow dose response, are not modified by red wine polyphenols.

Authors+Show Affiliations

University Health Network, Mount Sinai Hospital, Division of Cardiology, Department of Medicine, University of Toronto, Ontario, Canada. jonas.spaak@ds.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18055508

Citation

Spaak, Jonas, et al. "Dose-related Effects of Red Wine and Alcohol On Hemodynamics, Sympathetic Nerve Activity, and Arterial Diameter." American Journal of Physiology. Heart and Circulatory Physiology, vol. 294, no. 2, 2008, pp. H605-12.
Spaak J, Merlocco AC, Soleas GJ, et al. Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter. Am J Physiol Heart Circ Physiol. 2008;294(2):H605-12.
Spaak, J., Merlocco, A. C., Soleas, G. J., Tomlinson, G., Morris, B. L., Picton, P., ... Floras, J. S. (2008). Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter. American Journal of Physiology. Heart and Circulatory Physiology, 294(2), pp. H605-12.
Spaak J, et al. Dose-related Effects of Red Wine and Alcohol On Hemodynamics, Sympathetic Nerve Activity, and Arterial Diameter. Am J Physiol Heart Circ Physiol. 2008;294(2):H605-12. PubMed PMID: 18055508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter. AU - Spaak,Jonas, AU - Merlocco,Anthony C, AU - Soleas,George J, AU - Tomlinson,George, AU - Morris,Beverley L, AU - Picton,Peter, AU - Notarius,Catherine F, AU - Chan,Christopher T, AU - Floras,John S, Y1 - 2007/11/30/ PY - 2007/12/7/pubmed PY - 2008/4/1/medline PY - 2007/12/7/entrez SP - H605 EP - 12 JF - American journal of physiology. Heart and circulatory physiology JO - Am. J. Physiol. Heart Circ. Physiol. VL - 294 IS - 2 N2 - The cardiovascular benefits of light to moderate red wine consumption often have been attributed to its polyphenol constituents. However, the acute dose-related hemodynamic, vasodilator, and sympathetic neural effects of ethanol and red wine have not been characterized and compared in the same individual. We sought to test the hypotheses that responses to one and two alcoholic drinks differ and that red wine with high polyphenol content elicits a greater effect than ethanol alone. Thirteen volunteers (24-47 yr; 7 men, 6 women) drank wine, ethanol, and water in a randomized, single-blind trial on three occasions 2 wk apart. One drink of wine and ethanol increased blood alcohol to 38 +/- 2 and 39 +/- 2 mg/dl, respectively, and two drinks to 72 +/- 4 and 83 +/- 3 mg/dl, respectively. Wine quadrupled plasma resveratrol (P < 0.001) and increased catechin (P < 0.03). No intervention affected blood pressure. One drink had no heart rate effect, but two drinks of wine increased heart rate by 5.7 +/- 1.6 beats/min; P < 0.001). Cardiac output fell 0.8 +/- 0.3 l/min after one drink of ethanol and wine (both P < 0.02) but increased after two drinks of ethanol (+0.8 +/- 0.3 l/min) and wine (+1.2 +/- 0.3 l/min) (P < 0.01). One alcoholic drink did not alter muscle sympathetic nerve activity (MSNA), while two drinks increased MSNA by 9-10 bursts/min (P < 0.001). Brachial artery diameter increased after both one and two alcoholic drinks (P < 0.001). No beverage augmented, and the second wine dose attenuated (P = 0.02), flow-mediated vasodilation. One drink of ethanol dilates the brachial artery without activating sympathetic outflow, whereas two drinks increase MSNA, heart rate, and cardiac output. These acute effects, which exhibit a narrow dose response, are not modified by red wine polyphenols. SN - 0363-6135 UR - https://www.unboundmedicine.com/medline/citation/18055508/Dose_related_effects_of_red_wine_and_alcohol_on_hemodynamics_sympathetic_nerve_activity_and_arterial_diameter_ L2 - http://www.physiology.org/doi/full/10.1152/ajpheart.01162.2007?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -