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Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis.
Br J Psychiatry Suppl. 2007 Dec; 51:s123-7.BJ

Abstract

BACKGROUND

First-episode psychosis is typically preceded by a prodrome in which there is deterioration in global and social functioning.

AIMS

To examine whether the duration of the prodromal phase influences grey and white matter volumes at the onset of psychosis.

METHODS

Eighty-two people were scanned using magnetic resonance imaging when they developed a first episode of psychosis. The duration of the prodromal phase was estimated from detailed interviews and medical records. Voxel-based morphometry was used to assess neuroanatomical abnormalities.

RESULTS

A long prodromal phase was associated with smaller grey matter volumes in the cingulate, frontal and left insular cortex, and with less white matter volume bilaterally in the superior longitudinal and uncinate fasciculi and the cingulum.

CONCLUSIONS

The severity of volumetric abnormalities in first-episode psychosis was greater in those with a long prodrome.

Authors+Show Affiliations

King's College London, Institute of Psychiatry, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18055928

Citation

Lappin, Julia M., et al. "Duration of Prodromal Phase and Severity of Volumetric Abnormalities in First-episode Psychosis." The British Journal of Psychiatry. Supplement, vol. 51, 2007, pp. s123-7.
Lappin JM, Dazzan P, Morgan K, et al. Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis. Br J Psychiatry Suppl. 2007;51:s123-7.
Lappin, J. M., Dazzan, P., Morgan, K., Morgan, C., Chitnis, X., Suckling, J., Fearon, P., Jones, P. B., Leff, J., Murray, R. M., & McGuire, P. K. (2007). Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis. The British Journal of Psychiatry. Supplement, 51, s123-7. https://doi.org/10.1192/bjp.191.51.s123
Lappin JM, et al. Duration of Prodromal Phase and Severity of Volumetric Abnormalities in First-episode Psychosis. Br J Psychiatry Suppl. 2007;51:s123-7. PubMed PMID: 18055928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis. AU - Lappin,Julia M, AU - Dazzan,Paola, AU - Morgan,Kevin, AU - Morgan,Craig, AU - Chitnis,Xavier, AU - Suckling,John, AU - Fearon,Paul, AU - Jones,Peter B, AU - Leff,Julian, AU - Murray,Robin M, AU - McGuire,Philip K, PY - 2008/1/19/pubmed PY - 2008/4/22/medline PY - 2008/1/19/entrez SP - s123 EP - 7 JF - The British journal of psychiatry. Supplement JO - Br J Psychiatry Suppl VL - 51 N2 - BACKGROUND: First-episode psychosis is typically preceded by a prodrome in which there is deterioration in global and social functioning. AIMS: To examine whether the duration of the prodromal phase influences grey and white matter volumes at the onset of psychosis. METHODS: Eighty-two people were scanned using magnetic resonance imaging when they developed a first episode of psychosis. The duration of the prodromal phase was estimated from detailed interviews and medical records. Voxel-based morphometry was used to assess neuroanatomical abnormalities. RESULTS: A long prodromal phase was associated with smaller grey matter volumes in the cingulate, frontal and left insular cortex, and with less white matter volume bilaterally in the superior longitudinal and uncinate fasciculi and the cingulum. CONCLUSIONS: The severity of volumetric abnormalities in first-episode psychosis was greater in those with a long prodrome. SN - 0960-5371 UR - https://www.unboundmedicine.com/medline/citation/18055928/Duration_of_prodromal_phase_and_severity_of_volumetric_abnormalities_in_first_episode_psychosis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=18055928.ui DB - PRIME DP - Unbound Medicine ER -