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One-year effect of changing duration of untreated psychosis in a single catchment area.
Br J Psychiatry Suppl. 2007 Dec; 51:s128-32.BJ

Abstract

BACKGROUND

There is highly replicated positive correlation between longer duration of untreated psychosis and poorer outcome.

AIMS

To study the effect of early intervention in first psychosis on one-year outcome using an historical quasi-experimental design.

METHOD

We compare the outcome of two samples of first-episode psychosis from the same healthcare district at different time periods. The historical control sample was assessed during 1993-1994, before the establishment of a system for early detection of psychosis. The experimental sample is the early detection sample in the Early Treatment and Intervention in Psychosis study assessed during 1997-2000.

RESULTS

At 1-year follow-up, the early detection group was younger, had a smaller fraction of individuals with schizophrenia, had less severe negative and general symptoms and had more friends in the past year than the historical control group. No differences were found in clinical course (remission, relapse, continuously psychotic) or positive symptoms, but more patients in the early detection sample were treated as outpatients without hospitalisation.

CONCLUSIONS

Early detection of schizophrenia in one healthcare sector is associated with less severe deterioration at 1 year.

Authors+Show Affiliations

Stavanger University Hospital, Psychiatric Clinic, Division for Psychiatry, and Department of Psychiatry, University of Bergen, Norway. tklarsen@online.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18055929

Citation

Larsen, Tor K., et al. "One-year Effect of Changing Duration of Untreated Psychosis in a Single Catchment Area." The British Journal of Psychiatry. Supplement, vol. 51, 2007, pp. s128-32.
Larsen TK, Melle I, Friis S, et al. One-year effect of changing duration of untreated psychosis in a single catchment area. Br J Psychiatry Suppl. 2007;51:s128-32.
Larsen, T. K., Melle, I., Friis, S., Joa, I., Johannessen, J. O., Opjordsmoen, S., Simonsen, E., Vaglum, P., & McGlashan, T. H. (2007). One-year effect of changing duration of untreated psychosis in a single catchment area. The British Journal of Psychiatry. Supplement, 51, s128-32. https://doi.org/10.1192/bjp.191.51.s128
Larsen TK, et al. One-year Effect of Changing Duration of Untreated Psychosis in a Single Catchment Area. Br J Psychiatry Suppl. 2007;51:s128-32. PubMed PMID: 18055929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - One-year effect of changing duration of untreated psychosis in a single catchment area. AU - Larsen,Tor K, AU - Melle,Ingrid, AU - Friis,Svein, AU - Joa,Inge, AU - Johannessen,Jan Olav, AU - Opjordsmoen,Stein, AU - Simonsen,Erik, AU - Vaglum,Per, AU - McGlashan,Thomas H, PY - 2008/1/19/pubmed PY - 2008/4/22/medline PY - 2008/1/19/entrez SP - s128 EP - 32 JF - The British journal of psychiatry. Supplement JO - Br J Psychiatry Suppl VL - 51 N2 - BACKGROUND: There is highly replicated positive correlation between longer duration of untreated psychosis and poorer outcome. AIMS: To study the effect of early intervention in first psychosis on one-year outcome using an historical quasi-experimental design. METHOD: We compare the outcome of two samples of first-episode psychosis from the same healthcare district at different time periods. The historical control sample was assessed during 1993-1994, before the establishment of a system for early detection of psychosis. The experimental sample is the early detection sample in the Early Treatment and Intervention in Psychosis study assessed during 1997-2000. RESULTS: At 1-year follow-up, the early detection group was younger, had a smaller fraction of individuals with schizophrenia, had less severe negative and general symptoms and had more friends in the past year than the historical control group. No differences were found in clinical course (remission, relapse, continuously psychotic) or positive symptoms, but more patients in the early detection sample were treated as outpatients without hospitalisation. CONCLUSIONS: Early detection of schizophrenia in one healthcare sector is associated with less severe deterioration at 1 year. SN - 0960-5371 UR - https://www.unboundmedicine.com/medline/citation/18055929/One_year_effect_of_changing_duration_of_untreated_psychosis_in_a_single_catchment_area_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=18055929.ui DB - PRIME DP - Unbound Medicine ER -