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A more atherogenic serum lipoprotein profile is present in women with polycystic ovary syndrome: a case-control study.
J Clin Endocrinol Metab. 2008 Feb; 93(2):470-6.JC

Abstract

CONTEXT

Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory.

OBJECTIVE

Our objective was to identify changes in lipid metabolism in women with PCOS, and the relative impact of obesity, insulin resistance, and hyperandrogenism on lipid parameters.

DESIGN

This was a case-control study.

SETTING

The study was performed at a single referral center.

SUBJECTS

PCOS was diagnosed according to the 2003 Rotterdam criteria. Healthy mothers with regular menstrual cycles served as controls.

MAIN OUTCOME PARAMETERS

Fasting insulin, triglycerides (TGs), cholesterol, high-density lipoprotein (HDL)-cholesterol, apoA-I, and apoB were determined. Low-density lipoprotein (LDL)-cholesterol was calculated using the Friedewald formula.

RESULTS

We included 557 women with PCOS and 295 controls. After correction for age and body mass index, PCOS women had higher median levels of insulin (10.1 vs. 6.9 mU/liter), TGs (95 vs. 81 mg/dl), cholesterol (196 vs. 178 mg/dl), and LDL-cholesterol (125 vs. 106 mg/dl) in combination with lower levels of HDL-cholesterol (46 vs. 55 mg/dl) and apoA-I (118 vs. 146 mg/dl) compared with controls (all P values < or = 0.01). apoB levels were similar in cases and controls. Free androgen index, body mass index, SHBG, and estradiol were independent predictors of apoA-I levels in women with PCOS.

CONCLUSIONS

PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile.

Authors+Show Affiliations

Valkenburg O
Department of Gynecology and Obstetrics, Division of Reproductive Medicine, Room HS 508, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands. o.valkenburg@erasmusmc.nl
Steegers-Theunissen RP
No affiliation info available
Smedts HP
No affiliation info available
Dallinga-Thie GM
No affiliation info available
Fauser BC
No affiliation info available
Westerveld EH
No affiliation info available
Laven JS
No affiliation info available

MeSH

AdultApolipoprotein A-IApolipoproteins BAtherosclerosisCase-Control StudiesCholesterolCohort StudiesFemaleHumansHyperandrogenismInsulinInsulin ResistanceMultivariate AnalysisObesityPolycystic Ovary SyndromeRisk FactorsTriglycerides

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18056772

Citation

Valkenburg, Olivier, et al. "A More Atherogenic Serum Lipoprotein Profile Is Present in Women With Polycystic Ovary Syndrome: a Case-control Study." The Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 2, 2008, pp. 470-6.
Valkenburg O, Steegers-Theunissen RP, Smedts HP, et al. A more atherogenic serum lipoprotein profile is present in women with polycystic ovary syndrome: a case-control study. J Clin Endocrinol Metab. 2008;93(2):470-6.
Valkenburg, O., Steegers-Theunissen, R. P., Smedts, H. P., Dallinga-Thie, G. M., Fauser, B. C., Westerveld, E. H., & Laven, J. S. (2008). A more atherogenic serum lipoprotein profile is present in women with polycystic ovary syndrome: a case-control study. The Journal of Clinical Endocrinology and Metabolism, 93(2), 470-6.
Valkenburg O, et al. A More Atherogenic Serum Lipoprotein Profile Is Present in Women With Polycystic Ovary Syndrome: a Case-control Study. J Clin Endocrinol Metab. 2008;93(2):470-6. PubMed PMID: 18056772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A more atherogenic serum lipoprotein profile is present in women with polycystic ovary syndrome: a case-control study. AU - Valkenburg,Olivier, AU - Steegers-Theunissen,Regine P M, AU - Smedts,Huberdina P M, AU - Dallinga-Thie,Geesje M, AU - Fauser,Bart C J M, AU - Westerveld,Egbertine H, AU - Laven,Joop S E, Y1 - 2007/12/04/ PY - 2007/12/7/pubmed PY - 2008/4/11/medline PY - 2007/12/7/entrez SP - 470 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 93 IS - 2 N2 - CONTEXT: Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory. OBJECTIVE: Our objective was to identify changes in lipid metabolism in women with PCOS, and the relative impact of obesity, insulin resistance, and hyperandrogenism on lipid parameters. DESIGN: This was a case-control study. SETTING: The study was performed at a single referral center. SUBJECTS: PCOS was diagnosed according to the 2003 Rotterdam criteria. Healthy mothers with regular menstrual cycles served as controls. MAIN OUTCOME PARAMETERS: Fasting insulin, triglycerides (TGs), cholesterol, high-density lipoprotein (HDL)-cholesterol, apoA-I, and apoB were determined. Low-density lipoprotein (LDL)-cholesterol was calculated using the Friedewald formula. RESULTS: We included 557 women with PCOS and 295 controls. After correction for age and body mass index, PCOS women had higher median levels of insulin (10.1 vs. 6.9 mU/liter), TGs (95 vs. 81 mg/dl), cholesterol (196 vs. 178 mg/dl), and LDL-cholesterol (125 vs. 106 mg/dl) in combination with lower levels of HDL-cholesterol (46 vs. 55 mg/dl) and apoA-I (118 vs. 146 mg/dl) compared with controls (all P values < or = 0.01). apoB levels were similar in cases and controls. Free androgen index, body mass index, SHBG, and estradiol were independent predictors of apoA-I levels in women with PCOS. CONCLUSIONS: PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/18056772/A_more_atherogenic_serum_lipoprotein_profile_is_present_in_women_with_polycystic_ovary_syndrome:_a_case_control_study_ DB - PRIME DP - Unbound Medicine ER -