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Preconditioning repetitive transcranial magnetic stimulation of premotor cortex can reduce but not enhance short-term facilitation of primary motor cortex.
J Neurophysiol 2008; 99(2):564-70JN

Abstract

Short trains of suprathreshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over primary motor cortex (M1) evoke motor potentials (MEPs) in hand muscles that progressively increase in amplitude via a mechanism that is thought to be similar to short-term potentiation described in animal preparations. Long trains of subthreshold rTMS over dorsal premotor cortex (PMd) are known to affect the amplitude of single-pulse MEPs evoked from M1. We tested whether PMd-rTMS affects short-term facilitation in M1. We also explored the effect of PMd-rTMS on M1 responses evoked by single-pulse TMS of different polarities. We tested in 15 healthy subjects short-term facilitation in left M1 (10 suprathreshold TMS pulses at 5 Hz) after applying rTMS to left PMd (1,500 subthreshold pulses at 1 and 5 Hz). In a sample of subjects we delivered single-pulse TMS with different polarities and paired-pulse TMS at short intervals (SICI) after PMd-rTMS. Short-term facilitation in M1 was reduced after applying 1 Hz to PMd, but was unaffected after 5-Hz PMd-rTMS. PMd-rTMS with 1 Hz reduced the amplitude of MEPs evoked by monophasic posteroanterior (PA) or biphasic anteroposterior (AP)-PA but had little effect on MEPs by monophasic AP or biphasic PA-AP single-pulse TMS. PMd-rTMS left SICI unchanged. PMd-rTMS (1 Hz) reduces short-term facilitation in M1 induced by short 5-Hz trains. This effect is likely to be caused by reduced facilitation of I-wave inputs to corticospinal neurons.

Authors+Show Affiliations

Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18057113

Citation

Suppa, A, et al. "Preconditioning Repetitive Transcranial Magnetic Stimulation of Premotor Cortex Can Reduce but Not Enhance Short-term Facilitation of Primary Motor Cortex." Journal of Neurophysiology, vol. 99, no. 2, 2008, pp. 564-70.
Suppa A, Bologna M, Gilio F, et al. Preconditioning repetitive transcranial magnetic stimulation of premotor cortex can reduce but not enhance short-term facilitation of primary motor cortex. J Neurophysiol. 2008;99(2):564-70.
Suppa, A., Bologna, M., Gilio, F., Lorenzano, C., Rothwell, J. C., & Berardelli, A. (2008). Preconditioning repetitive transcranial magnetic stimulation of premotor cortex can reduce but not enhance short-term facilitation of primary motor cortex. Journal of Neurophysiology, 99(2), pp. 564-70.
Suppa A, et al. Preconditioning Repetitive Transcranial Magnetic Stimulation of Premotor Cortex Can Reduce but Not Enhance Short-term Facilitation of Primary Motor Cortex. J Neurophysiol. 2008;99(2):564-70. PubMed PMID: 18057113.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preconditioning repetitive transcranial magnetic stimulation of premotor cortex can reduce but not enhance short-term facilitation of primary motor cortex. AU - Suppa,A, AU - Bologna,M, AU - Gilio,F, AU - Lorenzano,C, AU - Rothwell,J C, AU - Berardelli,A, Y1 - 2007/12/05/ PY - 2007/12/7/pubmed PY - 2008/6/13/medline PY - 2007/12/7/entrez SP - 564 EP - 70 JF - Journal of neurophysiology JO - J. Neurophysiol. VL - 99 IS - 2 N2 - Short trains of suprathreshold 5-Hz repetitive transcranial magnetic stimulation (rTMS) over primary motor cortex (M1) evoke motor potentials (MEPs) in hand muscles that progressively increase in amplitude via a mechanism that is thought to be similar to short-term potentiation described in animal preparations. Long trains of subthreshold rTMS over dorsal premotor cortex (PMd) are known to affect the amplitude of single-pulse MEPs evoked from M1. We tested whether PMd-rTMS affects short-term facilitation in M1. We also explored the effect of PMd-rTMS on M1 responses evoked by single-pulse TMS of different polarities. We tested in 15 healthy subjects short-term facilitation in left M1 (10 suprathreshold TMS pulses at 5 Hz) after applying rTMS to left PMd (1,500 subthreshold pulses at 1 and 5 Hz). In a sample of subjects we delivered single-pulse TMS with different polarities and paired-pulse TMS at short intervals (SICI) after PMd-rTMS. Short-term facilitation in M1 was reduced after applying 1 Hz to PMd, but was unaffected after 5-Hz PMd-rTMS. PMd-rTMS with 1 Hz reduced the amplitude of MEPs evoked by monophasic posteroanterior (PA) or biphasic anteroposterior (AP)-PA but had little effect on MEPs by monophasic AP or biphasic PA-AP single-pulse TMS. PMd-rTMS left SICI unchanged. PMd-rTMS (1 Hz) reduces short-term facilitation in M1 induced by short 5-Hz trains. This effect is likely to be caused by reduced facilitation of I-wave inputs to corticospinal neurons. SN - 0022-3077 UR - https://www.unboundmedicine.com/medline/citation/18057113/Preconditioning_repetitive_transcranial_magnetic_stimulation_of_premotor_cortex_can_reduce_but_not_enhance_short_term_facilitation_of_primary_motor_cortex_ L2 - http://www.physiology.org/doi/full/10.1152/jn.00753.2007?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -