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A combination of soy isoflavone supplementation and exercise improves lipid profiles and protects antioxidant defense-systems against exercise-induced oxidative stress in ovariectomized rats.
Biofactors 2007; 29(4):175-85B

Abstract

Menopause is often accompanied with weight gain, metabolic lipid abnormalities, and oxidative stress. In this study, we investigated the combined effects of exercise and soy isoflavone supplementation on the lipid profiles and antioxidant capacities of ovariectomized rats. Twenty-five female Sprague-Dawley rats were divided into 5 groups: sham-operated, ovariectomized (OVX), OVX with exercise (OVX+EX), OVX with soy isoflavone supplementation (OVX+ISO), and OVX with both soy isoflavones and exercise (OVX+ISO+EX). After 12 weeks of intervention, antioxidant status was evaluated in collected blood samples by the ferric reducing ability of plasma (FRAP), glutathione (GSH) content, and sodium oxide dismutase (SOD) activity. DNA damage in the lymphocytes was determined using alkaline single-cell gel electrophoresis (the Comet assay). Although there were no significant differences in weight gain and food intake, weight gain was lower in OVX+EX, OVX+ISO, and OVX+ISO+EX than in OVX. OVX+EX, OVX+ISO, and OVX+ ISO+EX showed a significant decrease in total cholesterol, triglycerides, and LDL-cholesterol compared to OVX. The soy isoflavone supplemented group had significantly increased FRAP values and GSH contents in contrast to no changes in the exercised group, whereas exercise markedly increased SOD activity and H2O2-induced DNA tail length and tail moment. Exercise with soy isoflavone supplementation significantly increased FRAP values and had no difference on SOD activity, including DNA damage. These results demonstrate that a combined treatment of moderate exercise and soy isoflavone supplementation could exert a beneficial effect on weight control and lipid profiles, and offer protection from exercise-induced oxidative stress in postmenopausal women.

Authors+Show Affiliations

Department of Food and Nutrition, Brain Korea 21 Project, Yonsei University College of Human Ecology, Seodaemun-Gu, Seoul, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18057549

Citation

Oh, Hea Young, et al. "A Combination of Soy Isoflavone Supplementation and Exercise Improves Lipid Profiles and Protects Antioxidant Defense-systems Against Exercise-induced Oxidative Stress in Ovariectomized Rats." BioFactors (Oxford, England), vol. 29, no. 4, 2007, pp. 175-85.
Oh HY, Lim S, Lee JM, et al. A combination of soy isoflavone supplementation and exercise improves lipid profiles and protects antioxidant defense-systems against exercise-induced oxidative stress in ovariectomized rats. Biofactors. 2007;29(4):175-85.
Oh, H. Y., Lim, S., Lee, J. M., Kim, D. Y., Ann, E. S., & Yoon, S. (2007). A combination of soy isoflavone supplementation and exercise improves lipid profiles and protects antioxidant defense-systems against exercise-induced oxidative stress in ovariectomized rats. BioFactors (Oxford, England), 29(4), pp. 175-85.
Oh HY, et al. A Combination of Soy Isoflavone Supplementation and Exercise Improves Lipid Profiles and Protects Antioxidant Defense-systems Against Exercise-induced Oxidative Stress in Ovariectomized Rats. Biofactors. 2007;29(4):175-85. PubMed PMID: 18057549.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A combination of soy isoflavone supplementation and exercise improves lipid profiles and protects antioxidant defense-systems against exercise-induced oxidative stress in ovariectomized rats. AU - Oh,Hea Young, AU - Lim,Soyoung, AU - Lee,Joo Min, AU - Kim,Dae-Young, AU - Ann,Eue-Soo, AU - Yoon,Sun, PY - 2007/12/7/pubmed PY - 2008/4/15/medline PY - 2007/12/7/entrez SP - 175 EP - 85 JF - BioFactors (Oxford, England) JO - Biofactors VL - 29 IS - 4 N2 - Menopause is often accompanied with weight gain, metabolic lipid abnormalities, and oxidative stress. In this study, we investigated the combined effects of exercise and soy isoflavone supplementation on the lipid profiles and antioxidant capacities of ovariectomized rats. Twenty-five female Sprague-Dawley rats were divided into 5 groups: sham-operated, ovariectomized (OVX), OVX with exercise (OVX+EX), OVX with soy isoflavone supplementation (OVX+ISO), and OVX with both soy isoflavones and exercise (OVX+ISO+EX). After 12 weeks of intervention, antioxidant status was evaluated in collected blood samples by the ferric reducing ability of plasma (FRAP), glutathione (GSH) content, and sodium oxide dismutase (SOD) activity. DNA damage in the lymphocytes was determined using alkaline single-cell gel electrophoresis (the Comet assay). Although there were no significant differences in weight gain and food intake, weight gain was lower in OVX+EX, OVX+ISO, and OVX+ISO+EX than in OVX. OVX+EX, OVX+ISO, and OVX+ ISO+EX showed a significant decrease in total cholesterol, triglycerides, and LDL-cholesterol compared to OVX. The soy isoflavone supplemented group had significantly increased FRAP values and GSH contents in contrast to no changes in the exercised group, whereas exercise markedly increased SOD activity and H2O2-induced DNA tail length and tail moment. Exercise with soy isoflavone supplementation significantly increased FRAP values and had no difference on SOD activity, including DNA damage. These results demonstrate that a combined treatment of moderate exercise and soy isoflavone supplementation could exert a beneficial effect on weight control and lipid profiles, and offer protection from exercise-induced oxidative stress in postmenopausal women. SN - 0951-6433 UR - https://www.unboundmedicine.com/medline/citation/18057549/A_combination_of_soy_isoflavone_supplementation_and_exercise_improves_lipid_profiles_and_protects_antioxidant_defense_systems_against_exercise_induced_oxidative_stress_in_ovariectomized_rats_ L2 - https://content.iospress.com/openurl?genre=article&issn=0951-6433&volume=29&issue=4&spage=175 DB - PRIME DP - Unbound Medicine ER -