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Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years.
J Alzheimers Dis 2007; 12(3):255-60JA

Abstract

This study examines the intra-individual stability of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) over 2 years in 83 patients with mild cognitive impairment (MCI) and 17 cognitively healthy control individuals. All participants underwent clinical and neuropsychological evaluation and lumbar puncture at baseline and after 2 years at a university hospital memory clinic. CSF was analyzed for total tau (T-tau), phospho-tau(181) (P-tau(181)) and amyloid-beta(1-42) (Abeta(1-42)). During the 2-year observational time, 12 MCI patients progressed to AD and 3 progressed to vascular dementia, while 68 remained stable. Baseline T-tau and P-tau(181) levels were elevated in the MCI-AD group as compared to the stable MCI patients and the control group (p<0.01), while baseline Abeta(1-42) levels were lower (p<0.001). Stable MCI patients were biochemically indistinguishable from controls. The biomarker levels at baseline and after 2 years showed Pearson R values between 0.81 and 0.91 (p<0.001) and coefficients of variation of 7.2 to 8.7%. In conclusion, intra-individual biomarker levels are remarkably stable over 2 years. Thus, even minor biochemical changes induced by treatment against AD should be detectable using these biomarkers, which bodes well for their usefulness as surrogate markers for drug efficacy in clinical trials.

Authors+Show Affiliations

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at Göteborg University, Mölndal, Sweden. henrik.zetterberg@clinchem.gu.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18057559

Citation

Zetterberg, Henrik, et al. "Intra-individual Stability of CSF Biomarkers for Alzheimer's Disease Over Two Years." Journal of Alzheimer's Disease : JAD, vol. 12, no. 3, 2007, pp. 255-60.
Zetterberg H, Pedersen M, Lind K, et al. Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years. J Alzheimers Dis. 2007;12(3):255-60.
Zetterberg, H., Pedersen, M., Lind, K., Svensson, M., Rolstad, S., Eckerström, C., ... Wallin, A. (2007). Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years. Journal of Alzheimer's Disease : JAD, 12(3), pp. 255-60.
Zetterberg H, et al. Intra-individual Stability of CSF Biomarkers for Alzheimer's Disease Over Two Years. J Alzheimers Dis. 2007;12(3):255-60. PubMed PMID: 18057559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intra-individual stability of CSF biomarkers for Alzheimer's disease over two years. AU - Zetterberg,Henrik, AU - Pedersen,Mona, AU - Lind,Karin, AU - Svensson,Maria, AU - Rolstad,Sindre, AU - Eckerström,Carl, AU - Syversen,Steinar, AU - Mattsson,Ulla-Britt, AU - Ysander,Christina, AU - Mattsson,Niklas, AU - Nordlund,Arto, AU - Vanderstichele,Hugo, AU - Vanmechelen,Eugeen, AU - Jonsson,Michael, AU - Edman,Ake, AU - Blennow,Kaj, AU - Wallin,Anders, PY - 2007/12/7/pubmed PY - 2008/3/20/medline PY - 2007/12/7/entrez SP - 255 EP - 60 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 12 IS - 3 N2 - This study examines the intra-individual stability of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) over 2 years in 83 patients with mild cognitive impairment (MCI) and 17 cognitively healthy control individuals. All participants underwent clinical and neuropsychological evaluation and lumbar puncture at baseline and after 2 years at a university hospital memory clinic. CSF was analyzed for total tau (T-tau), phospho-tau(181) (P-tau(181)) and amyloid-beta(1-42) (Abeta(1-42)). During the 2-year observational time, 12 MCI patients progressed to AD and 3 progressed to vascular dementia, while 68 remained stable. Baseline T-tau and P-tau(181) levels were elevated in the MCI-AD group as compared to the stable MCI patients and the control group (p<0.01), while baseline Abeta(1-42) levels were lower (p<0.001). Stable MCI patients were biochemically indistinguishable from controls. The biomarker levels at baseline and after 2 years showed Pearson R values between 0.81 and 0.91 (p<0.001) and coefficients of variation of 7.2 to 8.7%. In conclusion, intra-individual biomarker levels are remarkably stable over 2 years. Thus, even minor biochemical changes induced by treatment against AD should be detectable using these biomarkers, which bodes well for their usefulness as surrogate markers for drug efficacy in clinical trials. SN - 1387-2877 UR - https://www.unboundmedicine.com/medline/citation/18057559/Intra_individual_stability_of_CSF_biomarkers_for_Alzheimer's_disease_over_two_years_ L2 - https://content.iospress.com/openurl?genre=article&amp;issn=1387-2877&amp;volume=12&amp;issue=3&amp;spage=255 DB - PRIME DP - Unbound Medicine ER -