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Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke.
Cerebrovasc Dis. 2008; 25(1-2):81-6.CD

Abstract

Polymorphisms in human platelet alloantigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa) and HPA-5 (GPIa/IIa) were investigated in 216 stroke patients and 318 matched control subjects. HPA genotyping was done by the polymerase chain reaction method using sequence-specific primers. Higher frequencies of the HPA-1 a/b (p < 0.001) and HPA-5 a/b (p < 0.001) allele, together with HPA-1 b/b, HPA-5 a/b and HPA-5 b/b genotypes were seen in patients, which was confirmed by regression analysis after controlling for a number of confounding variables. Furthermore, HPA-1 b/b and HPA-5 b/b were significantly associated with the extent of neurological symptoms, and with the recurrence of stroke. Both susceptible (1a/ b -2a/a-3a/ b -4a/a-5a/ b) and protective (1a/a-2a/a-3a/a-4a/a-5a/a; 1a/a-2a/a-3a/ b -4a/a-5a/a; 1a/ b -2a/a-3a/a-4a/a-5a/a; 1a/ b -2a/a-3a/ b -4a/a-5a/a) HPA genotypes were identified. This is the first evidence demonstrating differential association of the common 5 HPA gene variants with stroke, with HPA-1b and HPA-5b representing strong genetic risk factors.

Authors+Show Affiliations

Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18057877

Citation

Saidi, Sarra, et al. "Association of Human Platelet Alloantigen 1 Through 5 Polymorphisms With Ischemic Stroke." Cerebrovascular Diseases (Basel, Switzerland), vol. 25, no. 1-2, 2008, pp. 81-6.
Saidi S, Mahjoub T, Slamia LB, et al. Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke. Cerebrovasc Dis. 2008;25(1-2):81-6.
Saidi, S., Mahjoub, T., Slamia, L. B., Ammou, S. B., Al-Subaie, A. M., & Almawi, W. Y. (2008). Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke. Cerebrovascular Diseases (Basel, Switzerland), 25(1-2), 81-6.
Saidi S, et al. Association of Human Platelet Alloantigen 1 Through 5 Polymorphisms With Ischemic Stroke. Cerebrovasc Dis. 2008;25(1-2):81-6. PubMed PMID: 18057877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of human platelet alloantigen 1 through 5 polymorphisms with ischemic stroke. AU - Saidi,Sarra, AU - Mahjoub,Touhami, AU - Slamia,Lamia B, AU - Ammou,Sofyan B, AU - Al-Subaie,Abeer M, AU - Almawi,Wassim Y, Y1 - 2007/12/06/ PY - 2007/04/23/received PY - 2007/07/01/accepted PY - 2007/12/7/pubmed PY - 2008/4/11/medline PY - 2007/12/7/entrez SP - 81 EP - 6 JF - Cerebrovascular diseases (Basel, Switzerland) JO - Cerebrovasc. Dis. VL - 25 IS - 1-2 N2 - Polymorphisms in human platelet alloantigen (HPA)-1 and HPA-3 (GPIIb/IIIa), HPA-2 (GPIb/IX), HPA-4 (GPIIIa) and HPA-5 (GPIa/IIa) were investigated in 216 stroke patients and 318 matched control subjects. HPA genotyping was done by the polymerase chain reaction method using sequence-specific primers. Higher frequencies of the HPA-1 a/b (p < 0.001) and HPA-5 a/b (p < 0.001) allele, together with HPA-1 b/b, HPA-5 a/b and HPA-5 b/b genotypes were seen in patients, which was confirmed by regression analysis after controlling for a number of confounding variables. Furthermore, HPA-1 b/b and HPA-5 b/b were significantly associated with the extent of neurological symptoms, and with the recurrence of stroke. Both susceptible (1a/ b -2a/a-3a/ b -4a/a-5a/ b) and protective (1a/a-2a/a-3a/a-4a/a-5a/a; 1a/a-2a/a-3a/ b -4a/a-5a/a; 1a/ b -2a/a-3a/a-4a/a-5a/a; 1a/ b -2a/a-3a/ b -4a/a-5a/a) HPA genotypes were identified. This is the first evidence demonstrating differential association of the common 5 HPA gene variants with stroke, with HPA-1b and HPA-5b representing strong genetic risk factors. SN - 1421-9786 UR - https://www.unboundmedicine.com/medline/citation/18057877/Association_of_human_platelet_alloantigen_1_through_5_polymorphisms_with_ischemic_stroke_ L2 - https://www.karger.com?DOI=10.1159/000111995 DB - PRIME DP - Unbound Medicine ER -