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Design and applications of coupled SPE-CE.
Electrophoresis. 2008 Jan; 29(1):108-28.E

Abstract

CE suffers from an inherent low concentration sensitivity. Analyte detection limits can be improved by combining CE with SPE. This paper presents an overview of coupled SPE-CE systems that have been reported in literature. Attention is paid to fundamental aspects of coupling SPE and CE, as well as to important SPE requirements. Interfaces for inline and online coupling with CE are critically discussed, and their mode of operation is outlined. Advantages and limitations of the interfaces are discussed and typical examples are selected. Finally, some future developments are discussed.

Authors+Show Affiliations

Tempels FW
Division of Biomedical Analysis, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Underberg WJ
No affiliation info available
Somsen GW
No affiliation info available
de Jong GJ
No affiliation info available

MeSH

AnimalsElectrophoresis, CapillaryEquipment DesignHumansMiniaturizationOnline SystemsPharmaceutical PreparationsSolid Phase Extraction

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18058767

Citation

Tempels, F W Alexander, et al. "Design and Applications of Coupled SPE-CE." Electrophoresis, vol. 29, no. 1, 2008, pp. 108-28.
Tempels FW, Underberg WJ, Somsen GW, et al. Design and applications of coupled SPE-CE. Electrophoresis. 2008;29(1):108-28.
Tempels, F. W., Underberg, W. J., Somsen, G. W., & de Jong, G. J. (2008). Design and applications of coupled SPE-CE. Electrophoresis, 29(1), 108-28.
Tempels FW, et al. Design and Applications of Coupled SPE-CE. Electrophoresis. 2008;29(1):108-28. PubMed PMID: 18058767.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Design and applications of coupled SPE-CE. AU - Tempels,F W Alexander, AU - Underberg,Willy J M, AU - Somsen,Govert W, AU - de Jong,Gerhardus J, PY - 2007/12/7/pubmed PY - 2008/2/29/medline PY - 2007/12/7/entrez SP - 108 EP - 28 JF - Electrophoresis JO - Electrophoresis VL - 29 IS - 1 N2 - CE suffers from an inherent low concentration sensitivity. Analyte detection limits can be improved by combining CE with SPE. This paper presents an overview of coupled SPE-CE systems that have been reported in literature. Attention is paid to fundamental aspects of coupling SPE and CE, as well as to important SPE requirements. Interfaces for inline and online coupling with CE are critically discussed, and their mode of operation is outlined. Advantages and limitations of the interfaces are discussed and typical examples are selected. Finally, some future developments are discussed. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/18058767/Design_and_applications_of_coupled_SPE_CE_ DB - PRIME DP - Unbound Medicine ER -