Tags

Type your tag names separated by a space and hit enter

Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database.
Nutr Metab Cardiovasc Dis. 2008 Nov; 18(9):624-31.NM

Abstract

BACKGROUND AND AIMS

We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects.

METHODS AND RESULTS

A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose <6.1 mmol/l. Parallel analyses were conducted in all subjects in the database (n=1093) and in those with all variables available (n=309). In the univariate analysis both FPI and M were significantly correlated with TG, HDL-C, UA and BP (systolic, diastolic and mean). Multivariate regression analyses including center, sex, age, body mass index (BMI), FPI and M as independent variables showed that: (1) TG and UA were positively correlated with FPI and negatively correlated with M; (2) HDL-C was negatively correlated with FPI and positively correlated with M; and (3) BP was negatively correlated with both FPI and M. Analyses of covariance showed that, after adjusting for center, sex, age and BMI, subjects with isolated hyperinsulinemia or isolated insulin resistance had higher TG and UA and lower HDL-C. Subjects with isolated insulin resistance had also higher BP whereas subjects with isolated hyperinsulinemia had lower BP. Subjects with both defects had a worse profile.

CONCLUSIONS

Hyperinsulinemia and insulin resistance might contribute with distinct and independent mechanisms to the development of several metabolic and hemodynamic disorders often clustering in the same individual. In particular, hypertriglyceridemia, low HDL-cholesterol and hyperuricemia seem to be related to both hyperinsulinemia and insulin resistance, whereas hypertension seems to be related only to insulin resistance.

Authors+Show Affiliations

Bonora E
University of Verona, Verona, Italy. enzo.bonora@univr.it
Capaldo B
No affiliation info available
Perin PC
No affiliation info available
Del Prato S
No affiliation info available
De Mattia G
No affiliation info available
Frittitta L
No affiliation info available
Frontoni S
No affiliation info available
Leonetti F
No affiliation info available
Luzi L
No affiliation info available
Marchesini G
No affiliation info available
Marini MA
No affiliation info available
Natali A
No affiliation info available
Paolisso G
No affiliation info available
Piatti PM
No affiliation info available
Pujia A
No affiliation info available
Solini A
No affiliation info available
Vettor R
No affiliation info available
Bonadonna RC
No affiliation info available
Group of Italian Scientists of Insulin Resistance (GISIR)
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overBlood PressureCholesterol, HDLHumansHyperinsulinismInsulin ResistanceLipidsMiddle AgedTriglyceridesUric Acid

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18060751

Citation

Bonora, Enzo, et al. "Hyperinsulinemia and Insulin Resistance Are Independently Associated With Plasma Lipids, Uric Acid and Blood Pressure in Non-diabetic Subjects. the GISIR Database." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 18, no. 9, 2008, pp. 624-31.
Bonora E, Capaldo B, Perin PC, et al. Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. Nutr Metab Cardiovasc Dis. 2008;18(9):624-31.
Bonora, E., Capaldo, B., Perin, P. C., Del Prato, S., De Mattia, G., Frittitta, L., Frontoni, S., Leonetti, F., Luzi, L., Marchesini, G., Marini, M. A., Natali, A., Paolisso, G., Piatti, P. M., Pujia, A., Solini, A., Vettor, R., & Bonadonna, R. C. (2008). Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 18(9), 624-31.
Bonora E, et al. Hyperinsulinemia and Insulin Resistance Are Independently Associated With Plasma Lipids, Uric Acid and Blood Pressure in Non-diabetic Subjects. the GISIR Database. Nutr Metab Cardiovasc Dis. 2008;18(9):624-31. PubMed PMID: 18060751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database. AU - Bonora,Enzo, AU - Capaldo,Brunella, AU - Perin,Paolo Cavallo, AU - Del Prato,Stefano, AU - De Mattia,Giancarlo, AU - Frittitta,Lucia, AU - Frontoni,Simona, AU - Leonetti,Frida, AU - Luzi,Livio, AU - Marchesini,Giulio, AU - Marini,Maria Adelaide, AU - Natali,Andrea, AU - Paolisso,Giuseppe, AU - Piatti,Pier Marco, AU - Pujia,Arturo, AU - Solini,Anna, AU - Vettor,Roberto, AU - Bonadonna,Riccardo C, AU - ,, Y1 - 2007/12/03/ PY - 2007/01/18/received PY - 2007/04/04/revised PY - 2007/05/09/accepted PY - 2007/12/7/pubmed PY - 2009/1/28/medline PY - 2007/12/7/entrez SP - 624 EP - 31 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 18 IS - 9 N2 - BACKGROUND AND AIMS: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. METHODS AND RESULTS: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose <6.1 mmol/l. Parallel analyses were conducted in all subjects in the database (n=1093) and in those with all variables available (n=309). In the univariate analysis both FPI and M were significantly correlated with TG, HDL-C, UA and BP (systolic, diastolic and mean). Multivariate regression analyses including center, sex, age, body mass index (BMI), FPI and M as independent variables showed that: (1) TG and UA were positively correlated with FPI and negatively correlated with M; (2) HDL-C was negatively correlated with FPI and positively correlated with M; and (3) BP was negatively correlated with both FPI and M. Analyses of covariance showed that, after adjusting for center, sex, age and BMI, subjects with isolated hyperinsulinemia or isolated insulin resistance had higher TG and UA and lower HDL-C. Subjects with isolated insulin resistance had also higher BP whereas subjects with isolated hyperinsulinemia had lower BP. Subjects with both defects had a worse profile. CONCLUSIONS: Hyperinsulinemia and insulin resistance might contribute with distinct and independent mechanisms to the development of several metabolic and hemodynamic disorders often clustering in the same individual. In particular, hypertriglyceridemia, low HDL-cholesterol and hyperuricemia seem to be related to both hyperinsulinemia and insulin resistance, whereas hypertension seems to be related only to insulin resistance. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/18060751/Hyperinsulinemia_and_insulin_resistance_are_independently_associated_with_plasma_lipids_uric_acid_and_blood_pressure_in_non_diabetic_subjects__The_GISIR_database_ DB - PRIME DP - Unbound Medicine ER -