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Diagnostic capability of scanning laser polarimetry with variable cornea compensator in Indian patients with early primary open-angle glaucoma.
Ophthalmology. 2008 Jul; 115(7):1167-1172.e1.O

Abstract

PURPOSE

To evaluate the diagnostic ability of scanning laser polarimetry (GDx variable corneal compensator [VCC]) for early glaucoma in Asian Indian eyes.

DESIGN

Cross-sectional observational study.

PARTICIPANTS

Two groups of patients (early glaucoma and normal) who satisfied the inclusion and exclusion criteria were included. Early glaucoma was diagnosed in presence of open angles, characteristic glaucomatous optic disc changes correlating with the visual field (VF) on automated perimetry (VF defect fulfilling at least 2 of 3 Anderson and Patella's criteria with mean deviation >or= -6 decibels). Normal subjects had visual acuity >or= 20/30 and intraocular pressure < 22 mmHg, with a normal optic disc and fields and no ocular abnormality.

METHODS

All patients underwent complete ophthalmic evaluation, including VF examination (24-2/30-2 Swedish interactive threshold algorithm standard program) and imaging with GDx VCC.

MAIN OUTCOME MEASURES

Sensitivity, specificity, positive predictive value and negative predictive value, area under the receiving operating characteristic curve, and likelihood ratios (LRs) were calculated for various GDx VCC parameters.

RESULTS

Seventy-four eyes (74 patients) with early glaucoma and 104 eyes (104 normal subjects) were enrolled. TSNIT Std Dev (temporal-superior-nasal-inferior-temporal standard deviation) had the best combination of sensitivity and specificity-61.3 and 95.2, respectively-followed by nerve fiber index score > 50 (sensitivity, 52.7%; specificity, 99%). Nerve fiber index score > 50 had positive and negative predictive values of 74.3% and 97.6%, respectively, for an assumed glaucoma prevalence of 5%. Nerve fiber index score > 50 had a positive LR (+LR) of 54.8 for early glaucoma.

CONCLUSIONS

GDx VCC has moderate sensitivity, with high specificity, in the diagnosis of early glaucoma. The high +LR for the nerve fiber index score can provide valuable diagnostic information for individual patients.

Authors+Show Affiliations

LV Prasad Eye Institute, Hyderabad, India. rajulparikh@lvpei.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18061269

Citation

Parikh, Rajul S., et al. "Diagnostic Capability of Scanning Laser Polarimetry With Variable Cornea Compensator in Indian Patients With Early Primary Open-angle Glaucoma." Ophthalmology, vol. 115, no. 7, 2008, pp. 1167-1172.e1.
Parikh RS, Parikh SR, Kumar RS, et al. Diagnostic capability of scanning laser polarimetry with variable cornea compensator in Indian patients with early primary open-angle glaucoma. Ophthalmology. 2008;115(7):1167-1172.e1.
Parikh, R. S., Parikh, S. R., Kumar, R. S., Prabakaran, S., Babu, J. G., & Thomas, R. (2008). Diagnostic capability of scanning laser polarimetry with variable cornea compensator in Indian patients with early primary open-angle glaucoma. Ophthalmology, 115(7), 1167-e1.
Parikh RS, et al. Diagnostic Capability of Scanning Laser Polarimetry With Variable Cornea Compensator in Indian Patients With Early Primary Open-angle Glaucoma. Ophthalmology. 2008;115(7):1167-1172.e1. PubMed PMID: 18061269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic capability of scanning laser polarimetry with variable cornea compensator in Indian patients with early primary open-angle glaucoma. AU - Parikh,Rajul S, AU - Parikh,Shefali R, AU - Kumar,Rajesh S, AU - Prabakaran,S, AU - Babu,J Gansesh, AU - Thomas,Ravi, Y1 - 2007/12/03/ PY - 2007/02/13/received PY - 2007/09/21/revised PY - 2007/09/21/accepted PY - 2007/12/7/pubmed PY - 2008/7/17/medline PY - 2007/12/7/entrez SP - 1167 EP - 1172.e1 JF - Ophthalmology JO - Ophthalmology VL - 115 IS - 7 N2 - PURPOSE: To evaluate the diagnostic ability of scanning laser polarimetry (GDx variable corneal compensator [VCC]) for early glaucoma in Asian Indian eyes. DESIGN: Cross-sectional observational study. PARTICIPANTS: Two groups of patients (early glaucoma and normal) who satisfied the inclusion and exclusion criteria were included. Early glaucoma was diagnosed in presence of open angles, characteristic glaucomatous optic disc changes correlating with the visual field (VF) on automated perimetry (VF defect fulfilling at least 2 of 3 Anderson and Patella's criteria with mean deviation >or= -6 decibels). Normal subjects had visual acuity >or= 20/30 and intraocular pressure < 22 mmHg, with a normal optic disc and fields and no ocular abnormality. METHODS: All patients underwent complete ophthalmic evaluation, including VF examination (24-2/30-2 Swedish interactive threshold algorithm standard program) and imaging with GDx VCC. MAIN OUTCOME MEASURES: Sensitivity, specificity, positive predictive value and negative predictive value, area under the receiving operating characteristic curve, and likelihood ratios (LRs) were calculated for various GDx VCC parameters. RESULTS: Seventy-four eyes (74 patients) with early glaucoma and 104 eyes (104 normal subjects) were enrolled. TSNIT Std Dev (temporal-superior-nasal-inferior-temporal standard deviation) had the best combination of sensitivity and specificity-61.3 and 95.2, respectively-followed by nerve fiber index score > 50 (sensitivity, 52.7%; specificity, 99%). Nerve fiber index score > 50 had positive and negative predictive values of 74.3% and 97.6%, respectively, for an assumed glaucoma prevalence of 5%. Nerve fiber index score > 50 had a positive LR (+LR) of 54.8 for early glaucoma. CONCLUSIONS: GDx VCC has moderate sensitivity, with high specificity, in the diagnosis of early glaucoma. The high +LR for the nerve fiber index score can provide valuable diagnostic information for individual patients. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/18061269/Diagnostic_capability_of_scanning_laser_polarimetry_with_variable_cornea_compensator_in_Indian_patients_with_early_primary_open_angle_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(07)01040-8 DB - PRIME DP - Unbound Medicine ER -