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Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and their association with clinical outcome, troponin T and C-reactive protein in patients with acute coronary syndromes.
Clin Biochem. 2008 Feb; 41(3):126-33.CB

Abstract

OBJECTIVES

The aim of this study was to compare concentrations of soluble intercellular adhesion molecule (ICAM-1) and vascular cell adhesion molecule (VCAM-1) in patients with coronary artery disease and healthy control and to evaluate the usefulness of the inflammatory markers as predictors of adverse prognosis in patients with acute coronary syndromes (ACS).

DESIGN AND METHODS

ELISA was used to measure sICAM-1 and sVCAM-1 levels in 75 patients with ACS, 36 patients with stable angina pectoris (SAP) and 25 healthy subjects. hsCRP was measured with immunoturbidimetric assay, cardiac troponin T-with electrochemiluminescence immunoassay.

RESULTS

All soluble ICAM-1 and VCAM-1 significantly discriminated between patients with ACS and SAP (p=0.014 and 0.05, respectively) and control subjects (p<0.001 and 0.05). During the 6-month follow-up of the patients with ACS, there were 28 major cardiac events (37.3%). The odds ratio associated with the highest value of sVCAM-1 was 4.62 (95% CI 1.8-11.4, p=0.0009) without adjustment and remained significantly elevated after adjustment for cTnT (RR 3.93, 1.5-10, p=0.04) and hsCRP (RR 2.22, 0.8-5.7, p=0.05). In contrast, an elevated level of sICAM-1 was not associated with future coronary risk after adjustment for cTnT and hsCRP.

CONCLUSIONS

In patients with acute coronary syndromes, VCAM-1 serum levels powerfully predict an increased risk for subsequent cardiovascular events and extend the prognostic information gained from traditional biochemical markers.

Authors+Show Affiliations

Medical University Sofia, Bulgaria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18061588

Citation

Postadzhiyan, Arman S., et al. "Circulating Soluble Adhesion Molecules ICAM-1 and VCAM-1 and Their Association With Clinical Outcome, Troponin T and C-reactive Protein in Patients With Acute Coronary Syndromes." Clinical Biochemistry, vol. 41, no. 3, 2008, pp. 126-33.
Postadzhiyan AS, Tzontcheva AV, Kehayov I, et al. Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and their association with clinical outcome, troponin T and C-reactive protein in patients with acute coronary syndromes. Clin Biochem. 2008;41(3):126-33.
Postadzhiyan, A. S., Tzontcheva, A. V., Kehayov, I., & Finkov, B. (2008). Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and their association with clinical outcome, troponin T and C-reactive protein in patients with acute coronary syndromes. Clinical Biochemistry, 41(3), 126-33.
Postadzhiyan AS, et al. Circulating Soluble Adhesion Molecules ICAM-1 and VCAM-1 and Their Association With Clinical Outcome, Troponin T and C-reactive Protein in Patients With Acute Coronary Syndromes. Clin Biochem. 2008;41(3):126-33. PubMed PMID: 18061588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and their association with clinical outcome, troponin T and C-reactive protein in patients with acute coronary syndromes. AU - Postadzhiyan,Arman S, AU - Tzontcheva,Anna V, AU - Kehayov,Ivan, AU - Finkov,Bojidar, Y1 - 2007/09/19/ PY - 2007/04/24/received PY - 2007/08/14/revised PY - 2007/09/08/accepted PY - 2007/12/7/pubmed PY - 2008/6/6/medline PY - 2007/12/7/entrez SP - 126 EP - 33 JF - Clinical biochemistry JO - Clin Biochem VL - 41 IS - 3 N2 - OBJECTIVES: The aim of this study was to compare concentrations of soluble intercellular adhesion molecule (ICAM-1) and vascular cell adhesion molecule (VCAM-1) in patients with coronary artery disease and healthy control and to evaluate the usefulness of the inflammatory markers as predictors of adverse prognosis in patients with acute coronary syndromes (ACS). DESIGN AND METHODS: ELISA was used to measure sICAM-1 and sVCAM-1 levels in 75 patients with ACS, 36 patients with stable angina pectoris (SAP) and 25 healthy subjects. hsCRP was measured with immunoturbidimetric assay, cardiac troponin T-with electrochemiluminescence immunoassay. RESULTS: All soluble ICAM-1 and VCAM-1 significantly discriminated between patients with ACS and SAP (p=0.014 and 0.05, respectively) and control subjects (p<0.001 and 0.05). During the 6-month follow-up of the patients with ACS, there were 28 major cardiac events (37.3%). The odds ratio associated with the highest value of sVCAM-1 was 4.62 (95% CI 1.8-11.4, p=0.0009) without adjustment and remained significantly elevated after adjustment for cTnT (RR 3.93, 1.5-10, p=0.04) and hsCRP (RR 2.22, 0.8-5.7, p=0.05). In contrast, an elevated level of sICAM-1 was not associated with future coronary risk after adjustment for cTnT and hsCRP. CONCLUSIONS: In patients with acute coronary syndromes, VCAM-1 serum levels powerfully predict an increased risk for subsequent cardiovascular events and extend the prognostic information gained from traditional biochemical markers. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/18061588/Circulating_soluble_adhesion_molecules_ICAM_1_and_VCAM_1_and_their_association_with_clinical_outcome_troponin_T_and_C_reactive_protein_in_patients_with_acute_coronary_syndromes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(07)00355-4 DB - PRIME DP - Unbound Medicine ER -