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Antitumor effect of soluble beta-1,3-glucan from Agrobacterium sp. R259 KCTC 1019.
J Microbiol Biotechnol. 2007 Sep; 17(9):1513-20.JM

Abstract

Beta-1,3-glucans enhance immune reactions such as antitumor, antibacterial, antiviral, anticoagulatory, and wound healing activities. beta-1,3-Glucans have various functions depending on the molecular weight, degree of branching, conformation, water solubility, and intermolecular association. The molecular weight of the soluble glucan was about 15,000 as determined by a high-performance size exclusion chromatography. From the infrared (IR) and 13C NMR analytical data, the purified soluble glucan was found to exclusively consist of beta-D-glucopyranose with 1,3 linkage. We tested the immunestimulating activities of the soluble beta-1,3-glucan extracted from Agrobacterium sp. R259 KCTC 1019 and confirmed the following activities. IFN-gamma and each cytokines were induced in the spleens and thymus of mice treated with soluble beta-1,3-glucan. Adjuvant effect was observed on antibody production. Nitric oxide was synthesized in monocytic cell lines treated with beta-1,3-glucan. The cytotoxic and antitumor effects were observed on various cancer cell lines and ICR mice. These results strongly suggested that this soluble beta-1,3-glucan could be a good candidate for an immune-modulating agent.

Authors+Show Affiliations

Shim JH
Department of Bioscience and Biotechnology, Konkuk University, Seoul 143- 701, Korea.
Sung KJ
No affiliation info available
Cho MC
No affiliation info available
Choi WA
No affiliation info available
Yang Y
No affiliation info available
Lim JS
No affiliation info available
Yoon DY
No affiliation info available

MeSH

AnimalsAntineoplastic AgentsCell Line, TumorCell ProliferationDisease Models, AnimalMagnetic Resonance SpectroscopyMiceMice, Inbred ICRNeoplasm MetastasisRhizobiumSolubilityWaterbeta-Glucans

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18062230

Citation

Shim, Jung-Hyun, et al. "Antitumor Effect of Soluble Beta-1,3-glucan From Agrobacterium Sp. R259 KCTC 1019." Journal of Microbiology and Biotechnology, vol. 17, no. 9, 2007, pp. 1513-20.
Shim JH, Sung KJ, Cho MC, et al. Antitumor effect of soluble beta-1,3-glucan from Agrobacterium sp. R259 KCTC 1019. J Microbiol Biotechnol. 2007;17(9):1513-20.
Shim, J. H., Sung, K. J., Cho, M. C., Choi, W. A., Yang, Y., Lim, J. S., & Yoon, D. Y. (2007). Antitumor effect of soluble beta-1,3-glucan from Agrobacterium sp. R259 KCTC 1019. Journal of Microbiology and Biotechnology, 17(9), 1513-20.
Shim JH, et al. Antitumor Effect of Soluble Beta-1,3-glucan From Agrobacterium Sp. R259 KCTC 1019. J Microbiol Biotechnol. 2007;17(9):1513-20. PubMed PMID: 18062230.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor effect of soluble beta-1,3-glucan from Agrobacterium sp. R259 KCTC 1019. AU - Shim,Jung-Hyun, AU - Sung,Ki-Joong, AU - Cho,Min-Chul, AU - Choi,Won-A, AU - Yang,Young, AU - Lim,Jong-Seok, AU - Yoon,Do-Young, PY - 2007/12/8/pubmed PY - 2008/3/21/medline PY - 2007/12/8/entrez SP - 1513 EP - 20 JF - Journal of microbiology and biotechnology JO - J Microbiol Biotechnol VL - 17 IS - 9 N2 - Beta-1,3-glucans enhance immune reactions such as antitumor, antibacterial, antiviral, anticoagulatory, and wound healing activities. beta-1,3-Glucans have various functions depending on the molecular weight, degree of branching, conformation, water solubility, and intermolecular association. The molecular weight of the soluble glucan was about 15,000 as determined by a high-performance size exclusion chromatography. From the infrared (IR) and 13C NMR analytical data, the purified soluble glucan was found to exclusively consist of beta-D-glucopyranose with 1,3 linkage. We tested the immunestimulating activities of the soluble beta-1,3-glucan extracted from Agrobacterium sp. R259 KCTC 1019 and confirmed the following activities. IFN-gamma and each cytokines were induced in the spleens and thymus of mice treated with soluble beta-1,3-glucan. Adjuvant effect was observed on antibody production. Nitric oxide was synthesized in monocytic cell lines treated with beta-1,3-glucan. The cytotoxic and antitumor effects were observed on various cancer cell lines and ICR mice. These results strongly suggested that this soluble beta-1,3-glucan could be a good candidate for an immune-modulating agent. SN - 1017-7825 UR - https://www.unboundmedicine.com/medline/citation/18062230/Antitumor_effect_of_soluble_beta_13_glucan_from_Agrobacterium_sp__R259_KCTC_1019_ DB - PRIME DP - Unbound Medicine ER -