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Antitumor, antioxidant and antimicrobial activities of Bersama engleriana (Melianthaceae).
J Ethnopharmacol. 2008 Feb 12; 115(3):494-501.JE

Abstract

The aim of this study was to evaluate the antitumor, antioxidant and antimicrobial activities as well as the phytochemical composition and the acute toxicity of the methanolic extracts from the roots (BER), stem bark (BEB), leaves (BEL) and wood (BEW) of Bersama engleriana. The crown gall tumor and DPPH radical scavenging assays were used to detect respectively the antitumoral and oxidant activities. Agar diffusion and liquid dilution were used for antimicrobial tests and the phytochemical assays were conducted according to Harbone methods. The single-dose oral toxicity test was performed in accordance with the OPPTS 870.1100 and OECD 401 guidelines. The phytochemical tests indicated the presence of flavonoids, phenols, triterpenes and anthraquinones in all extracts. Pronounced tumor reducing activity was observed with the extracts from the roots (69.32%) and leaves (65.42%). The DPPH scavenging activity showed that the extract from the leaves was the most active with 93.71% inhibition rate at the 1000 microg/ml. The results of antimicrobial activity showed that all tested extracts were active against all tested microbial species, including Gram-positive, and negative bacteria, the two Candida species and mycobacteria. The MIC values obtained ranged from 9.76 to 156.25 microg/ml. Under the conditions of the studied toxicity, all extracts were found to be non-toxic. The overall results of this study indicates that the extracts from the roots, stem bark, leaves and wood have interesting antioxidant properties and represent a potential source of medicine for the treatment of infectious diseases and cancer.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, University of Yaoundé I, BP 812 Yaoundé, Cameroon. kuetevictor@yahoo.fr <kuetevictor@yahoo.fr>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18063329

Citation

Kuete, Victor, et al. "Antitumor, Antioxidant and Antimicrobial Activities of Bersama Engleriana (Melianthaceae)." Journal of Ethnopharmacology, vol. 115, no. 3, 2008, pp. 494-501.
Kuete V, Mbaveng AT, Tsaffack M, et al. Antitumor, antioxidant and antimicrobial activities of Bersama engleriana (Melianthaceae). J Ethnopharmacol. 2008;115(3):494-501.
Kuete, V., Mbaveng, A. T., Tsaffack, M., Beng, V. P., Etoa, F. X., Nkengfack, A. E., Meyer, J. J., & Lall, N. (2008). Antitumor, antioxidant and antimicrobial activities of Bersama engleriana (Melianthaceae). Journal of Ethnopharmacology, 115(3), 494-501.
Kuete V, et al. Antitumor, Antioxidant and Antimicrobial Activities of Bersama Engleriana (Melianthaceae). J Ethnopharmacol. 2008 Feb 12;115(3):494-501. PubMed PMID: 18063329.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antitumor, antioxidant and antimicrobial activities of Bersama engleriana (Melianthaceae). AU - Kuete,Victor, AU - Mbaveng,Armelle Tsafack, AU - Tsaffack,Maurice, AU - Beng,Véronique Penlap, AU - Etoa,Francois-Xavier, AU - Nkengfack,Augustin Ephraim, AU - Meyer,J J Marion, AU - Lall,Namrita, Y1 - 2007/10/26/ PY - 2007/07/26/received PY - 2007/08/31/revised PY - 2007/10/16/accepted PY - 2007/12/8/pubmed PY - 2008/4/4/medline PY - 2007/12/8/entrez SP - 494 EP - 501 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 115 IS - 3 N2 - The aim of this study was to evaluate the antitumor, antioxidant and antimicrobial activities as well as the phytochemical composition and the acute toxicity of the methanolic extracts from the roots (BER), stem bark (BEB), leaves (BEL) and wood (BEW) of Bersama engleriana. The crown gall tumor and DPPH radical scavenging assays were used to detect respectively the antitumoral and oxidant activities. Agar diffusion and liquid dilution were used for antimicrobial tests and the phytochemical assays were conducted according to Harbone methods. The single-dose oral toxicity test was performed in accordance with the OPPTS 870.1100 and OECD 401 guidelines. The phytochemical tests indicated the presence of flavonoids, phenols, triterpenes and anthraquinones in all extracts. Pronounced tumor reducing activity was observed with the extracts from the roots (69.32%) and leaves (65.42%). The DPPH scavenging activity showed that the extract from the leaves was the most active with 93.71% inhibition rate at the 1000 microg/ml. The results of antimicrobial activity showed that all tested extracts were active against all tested microbial species, including Gram-positive, and negative bacteria, the two Candida species and mycobacteria. The MIC values obtained ranged from 9.76 to 156.25 microg/ml. Under the conditions of the studied toxicity, all extracts were found to be non-toxic. The overall results of this study indicates that the extracts from the roots, stem bark, leaves and wood have interesting antioxidant properties and represent a potential source of medicine for the treatment of infectious diseases and cancer. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18063329/Antitumor_antioxidant_and_antimicrobial_activities_of_Bersama_engleriana__Melianthaceae__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00551-X DB - PRIME DP - Unbound Medicine ER -