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Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue.
Gen Physiol Biophys 2007; 26(3):221-9GP

Abstract

Elevated serum resistin is implicated in insulin resistance associated with obesity and type 2 diabetes mellitus. Alcohol consumption interferes with the nutritional status, metabolic and hormonal activity of the drinker. Impact of ethanol intake on resistin level and resistin metabolic effects is unknown. Effect of long-time (28 days) ad libitum moderate alcohol (6% ethanol solution) intake on serum resistin and resistin mRNA level in adipose tissue of rats (A) was compared to control (C) and pair-fed (PF) animals. PF rats were fed the same caloric amount as A rats on previous day. Alcohol consumption resulted in reduction of food and energy intake, decreased body mass gain, epididymal fat pads mass and smaller adipocytes (vs. C rats). Alcohol intake significantly increased serum resistin and glucose, insulinemia remained unchanged. Systemic insulin resistance was not proved by HOMA, QUICKI and McAuley indexes, but impaired insulin effect on glucose transport in isolated adipocytes was present. Elevated serum resistin was positively correlated with glycemia (r = 0.88, p < 0.01) and negatively with fat cell size (r = -0.73, p < 0.05). High resistin level as the consequence of long-time alcohol intake could contribute to smaller adipocytes, higher glycemia, attenuation of insulin-stimulated glucose transport in adipocytes. Diminished resistin gene expression in adipose tissue of A and PF rats was present.

Authors+Show Affiliations

Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlárska 3, 833 06 Bratislava, Slovakia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18063850

Citation

Pravdová, E, et al. "Long-time Alcohol Intake Modifies Resistin Secretion and Expression of Resistin Gene in Adipose Tissue." General Physiology and Biophysics, vol. 26, no. 3, 2007, pp. 221-9.
Pravdová E, Macho L, Hlavácová N, et al. Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue. Gen Physiol Biophys. 2007;26(3):221-9.
Pravdová, E., Macho, L., Hlavácová, N., & Ficková, M. (2007). Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue. General Physiology and Biophysics, 26(3), pp. 221-9.
Pravdová E, et al. Long-time Alcohol Intake Modifies Resistin Secretion and Expression of Resistin Gene in Adipose Tissue. Gen Physiol Biophys. 2007;26(3):221-9. PubMed PMID: 18063850.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-time alcohol intake modifies resistin secretion and expression of resistin gene in adipose tissue. AU - Pravdová,E, AU - Macho,L, AU - Hlavácová,N, AU - Ficková,M, PY - 2007/12/8/pubmed PY - 2008/2/20/medline PY - 2007/12/8/entrez SP - 221 EP - 9 JF - General physiology and biophysics JO - Gen. Physiol. Biophys. VL - 26 IS - 3 N2 - Elevated serum resistin is implicated in insulin resistance associated with obesity and type 2 diabetes mellitus. Alcohol consumption interferes with the nutritional status, metabolic and hormonal activity of the drinker. Impact of ethanol intake on resistin level and resistin metabolic effects is unknown. Effect of long-time (28 days) ad libitum moderate alcohol (6% ethanol solution) intake on serum resistin and resistin mRNA level in adipose tissue of rats (A) was compared to control (C) and pair-fed (PF) animals. PF rats were fed the same caloric amount as A rats on previous day. Alcohol consumption resulted in reduction of food and energy intake, decreased body mass gain, epididymal fat pads mass and smaller adipocytes (vs. C rats). Alcohol intake significantly increased serum resistin and glucose, insulinemia remained unchanged. Systemic insulin resistance was not proved by HOMA, QUICKI and McAuley indexes, but impaired insulin effect on glucose transport in isolated adipocytes was present. Elevated serum resistin was positively correlated with glycemia (r = 0.88, p < 0.01) and negatively with fat cell size (r = -0.73, p < 0.05). High resistin level as the consequence of long-time alcohol intake could contribute to smaller adipocytes, higher glycemia, attenuation of insulin-stimulated glucose transport in adipocytes. Diminished resistin gene expression in adipose tissue of A and PF rats was present. SN - 0231-5882 UR - https://www.unboundmedicine.com/medline/citation/18063850/Long_time_alcohol_intake_modifies_resistin_secretion_and_expression_of_resistin_gene_in_adipose_tissue_ L2 - https://medlineplus.gov/alcohol.html DB - PRIME DP - Unbound Medicine ER -