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[Cigarette smoking and gastric cancer risk in a community-based cohort study in Korea].
J Prev Med Public Health 2007; 40(6):467-74JP

Abstract

OBJECTIVES

Gastric cancer is the most common incident cancer in Korea. Although Helicobacter pylori infection is the most important risk factor for the development of gastric cancer, cigarette smoking has also been suggested to play an important role in the development of gastric cancer. The objective of this study is to evaluate the relationship between cigarette smoking and gastric cancer risk in a Korean population.

METHODS

The study population consisted of 13,785 subjects who had been enrolled in the Korean Multi-Center Cancer Cohort between 1993 and 2002. As of December 2002, 139 incident gastric cancer cases were ascertained through the Korea Central Cancer Registry and the National Death Certificate Database. Relative risks (RR) and 95% confidence intervals (CI) for gastric cancer were estimated using Cox's proportional hazard model adjusted for age, education, alcohol drinking status and history of gastritis or ulcer.

RESULTS

Significant dose-response relationships were observed between the duration of smoking and the risk of gastric cancer among the male subjects in comparison to non-smokers: men who smoked for 20-39 years had a 2.09- fold (95% CI 1.00-4.38) increase, and those who smoked for more than 40 years had a 3.13-fold (95% CI 1.59-6.17) increase in the risk of gastric cancer (P trend<0.01).

CONCLUSIONS

This study suggests that a longer duration of cigarette smoking may increase the risk of gastric cancer development in a dose-response manner in Korean men. The association between smoking and gastric cancer risk in women should be verified in future studies with a larger number of cases.

Authors+Show Affiliations

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Multicenter Study

Language

kor

PubMed ID

18063902

Citation

Kim, Yeonju, et al. "[Cigarette Smoking and Gastric Cancer Risk in a Community-based Cohort Study in Korea]." Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, vol. 40, no. 6, 2007, pp. 467-74.
Kim Y, Shin A, Gwack J, et al. [Cigarette smoking and gastric cancer risk in a community-based cohort study in Korea]. J Prev Med Public Health. 2007;40(6):467-74.
Kim, Y., Shin, A., Gwack, J., Jun, J. K., Park, S. K., Kang, D., ... Yoo, K. Y. (2007). [Cigarette smoking and gastric cancer risk in a community-based cohort study in Korea]. Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, 40(6), pp. 467-74.
Kim Y, et al. [Cigarette Smoking and Gastric Cancer Risk in a Community-based Cohort Study in Korea]. J Prev Med Public Health. 2007;40(6):467-74. PubMed PMID: 18063902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cigarette smoking and gastric cancer risk in a community-based cohort study in Korea]. AU - Kim,Yeonju, AU - Shin,Aesun, AU - Gwack,Jin, AU - Jun,Jae Kwan, AU - Park,Sue Kyung, AU - Kang,Daehee, AU - Shin,Hai-Rim, AU - Chang,Soung-Hoon, AU - Yoo,Keun-Young, PY - 2007/12/8/pubmed PY - 2008/1/30/medline PY - 2007/12/8/entrez SP - 467 EP - 74 JF - Journal of preventive medicine and public health = Yebang Uihakhoe chi JO - J Prev Med Public Health VL - 40 IS - 6 N2 - OBJECTIVES: Gastric cancer is the most common incident cancer in Korea. Although Helicobacter pylori infection is the most important risk factor for the development of gastric cancer, cigarette smoking has also been suggested to play an important role in the development of gastric cancer. The objective of this study is to evaluate the relationship between cigarette smoking and gastric cancer risk in a Korean population. METHODS: The study population consisted of 13,785 subjects who had been enrolled in the Korean Multi-Center Cancer Cohort between 1993 and 2002. As of December 2002, 139 incident gastric cancer cases were ascertained through the Korea Central Cancer Registry and the National Death Certificate Database. Relative risks (RR) and 95% confidence intervals (CI) for gastric cancer were estimated using Cox's proportional hazard model adjusted for age, education, alcohol drinking status and history of gastritis or ulcer. RESULTS: Significant dose-response relationships were observed between the duration of smoking and the risk of gastric cancer among the male subjects in comparison to non-smokers: men who smoked for 20-39 years had a 2.09- fold (95% CI 1.00-4.38) increase, and those who smoked for more than 40 years had a 3.13-fold (95% CI 1.59-6.17) increase in the risk of gastric cancer (P trend<0.01). CONCLUSIONS: This study suggests that a longer duration of cigarette smoking may increase the risk of gastric cancer development in a dose-response manner in Korean men. The association between smoking and gastric cancer risk in women should be verified in future studies with a larger number of cases. SN - 1975-8375 UR - https://www.unboundmedicine.com/medline/citation/18063902/[Cigarette_smoking_and_gastric_cancer_risk_in_a_community_based_cohort_study_in_Korea]_ L2 - https://medlineplus.gov/stomachcancer.html DB - PRIME DP - Unbound Medicine ER -