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Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography.
Thromb Haemost. 2007 Dec; 98(6):1350-6.TH

Abstract

In a study population consisting of healthy men (n = 8), women not using oral contraceptives (OC) (n = 28) and women using different kinds of OC (n = 187) we used calibrated automated thrombography (CAT) in the absence and presence of added activated protein C (APC) to compare parameters that can be obtained from thrombin generation curves, i.e. lag time, time to peak, peak height and endogenous thrombin potential (ETP). Both with and without APC, plasmas of OC users exhibited the shortest lag time and time to peak, and the highest peak height and ETP. In the absence of APC none of these parameters differed between users of OC containing different progestogens. In contrast, in the presence of APC shorter lag times and time to peak, and higher peak height and ETP were observed in plasma of users of gestodene-, desogestrel-, drospirenone- and cyproterone acetate-containing OC than in plasma of users of levonorgestrel- containing OC. The ETP determined in the absence of APC (ETP(-APC)) had no predictive value for the APCsr (r = 0.11; slope 0.9 x 10(-3); 95% CI: -0.1 x 10(-3) to 2.0 x 10(-3)) whereas the ETP measured in the presence of APC (ETP+APC) showed an excellent correlation with the APCsr (r = 0.95; slope 6.6 x 10(-3); 95% CI: 6.3 x 10(-3) to 6.9 x 10(-3)) indicating that the APCsr is entirely determined by the ETP+APC. In conclusion, OC use increases thrombin generation, but differential effects of second and third generation OCs on the protein C system likely determine the differences in the risk of venous thrombosis between these kinds of OC.

Authors+Show Affiliations

Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18064335

Citation

Tchaikovski, Svetlana N., et al. "Effect of Oral Contraceptives On Thrombin Generation Measured Via Calibrated Automated Thrombography." Thrombosis and Haemostasis, vol. 98, no. 6, 2007, pp. 1350-6.
Tchaikovski SN, van Vliet HA, Thomassen MC, et al. Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography. Thromb Haemost. 2007;98(6):1350-6.
Tchaikovski, S. N., van Vliet, H. A., Thomassen, M. C., Bertina, R. M., Rosendaal, F. R., Sandset, P. M., Helmerhorst, F. M., Tans, G., & Rosing, J. (2007). Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography. Thrombosis and Haemostasis, 98(6), 1350-6.
Tchaikovski SN, et al. Effect of Oral Contraceptives On Thrombin Generation Measured Via Calibrated Automated Thrombography. Thromb Haemost. 2007;98(6):1350-6. PubMed PMID: 18064335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of oral contraceptives on thrombin generation measured via calibrated automated thrombography. AU - Tchaikovski,Svetlana N, AU - van Vliet,Huib A A M, AU - Thomassen,M C L G D, AU - Bertina,Rogier M, AU - Rosendaal,Frits R, AU - Sandset,Per-Morten, AU - Helmerhorst,Frans M, AU - Tans,Guido, AU - Rosing,Jan, PY - 2007/12/8/pubmed PY - 2008/2/27/medline PY - 2007/12/8/entrez SP - 1350 EP - 6 JF - Thrombosis and haemostasis JO - Thromb Haemost VL - 98 IS - 6 N2 - In a study population consisting of healthy men (n = 8), women not using oral contraceptives (OC) (n = 28) and women using different kinds of OC (n = 187) we used calibrated automated thrombography (CAT) in the absence and presence of added activated protein C (APC) to compare parameters that can be obtained from thrombin generation curves, i.e. lag time, time to peak, peak height and endogenous thrombin potential (ETP). Both with and without APC, plasmas of OC users exhibited the shortest lag time and time to peak, and the highest peak height and ETP. In the absence of APC none of these parameters differed between users of OC containing different progestogens. In contrast, in the presence of APC shorter lag times and time to peak, and higher peak height and ETP were observed in plasma of users of gestodene-, desogestrel-, drospirenone- and cyproterone acetate-containing OC than in plasma of users of levonorgestrel- containing OC. The ETP determined in the absence of APC (ETP(-APC)) had no predictive value for the APCsr (r = 0.11; slope 0.9 x 10(-3); 95% CI: -0.1 x 10(-3) to 2.0 x 10(-3)) whereas the ETP measured in the presence of APC (ETP+APC) showed an excellent correlation with the APCsr (r = 0.95; slope 6.6 x 10(-3); 95% CI: 6.3 x 10(-3) to 6.9 x 10(-3)) indicating that the APCsr is entirely determined by the ETP+APC. In conclusion, OC use increases thrombin generation, but differential effects of second and third generation OCs on the protein C system likely determine the differences in the risk of venous thrombosis between these kinds of OC. SN - 0340-6245 UR - https://www.unboundmedicine.com/medline/citation/18064335/Effect_of_oral_contraceptives_on_thrombin_generation_measured_via_calibrated_automated_thrombography_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=18064335.ui DB - PRIME DP - Unbound Medicine ER -