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Diagnostic value of D-dimer for deep venous thrombosis in outpatients.
Haemostasis. 1991; 21(5):286-92.H

Abstract

We have studied the diagnostic value for deep venous thrombosis (DVT) of an enzyme immunoassay (EIA) for the detection of D-dimer in plasma of 239 consecutive outpatients suspected of having DVT by their general practitioner. DVT was confirmed by impedance plethysmography in 60 patients. Using the 95th percentile range of 42 healthy volunteers, the sensitivity for the detection of DVT was 92%, with a specificity of 21%. In our population with a prevalence of 25%, the D-dimer EIA showed a negative predictive value of 88% and a positive predictive value of 28%. We conclude that this D-dimer ELISA has limited value, either to confirm or to exclude DVT in outpatients.

Authors+Show Affiliations

Kroneman H
Erasmus University Rotterdam, Center for Clinical Decision Analysis, The Netherlands.
Van Bergen PF
No affiliation info available
Knot EA
No affiliation info available
Jonker JJ
No affiliation info available
de Maat MP
No affiliation info available

MeSH

AdultAgedAged, 80 and overFemaleFibrin Fibrinogen Degradation ProductsHumansImmunoenzyme TechniquesMaleMiddle AgedPlethysmography, ImpedancePredictive Value of TestsPrevalenceThrombophlebitis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1806457

Citation

Kroneman, H, et al. "Diagnostic Value of D-dimer for Deep Venous Thrombosis in Outpatients." Haemostasis, vol. 21, no. 5, 1991, pp. 286-92.
Kroneman H, Van Bergen PF, Knot EA, et al. Diagnostic value of D-dimer for deep venous thrombosis in outpatients. Haemostasis. 1991;21(5):286-92.
Kroneman, H., Van Bergen, P. F., Knot, E. A., Jonker, J. J., & de Maat, M. P. (1991). Diagnostic value of D-dimer for deep venous thrombosis in outpatients. Haemostasis, 21(5), 286-92.
Kroneman H, et al. Diagnostic Value of D-dimer for Deep Venous Thrombosis in Outpatients. Haemostasis. 1991;21(5):286-92. PubMed PMID: 1806457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnostic value of D-dimer for deep venous thrombosis in outpatients. AU - Kroneman,H, AU - Van Bergen,P F, AU - Knot,E A, AU - Jonker,J J, AU - de Maat,M P, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 286 EP - 92 JF - Haemostasis JO - Haemostasis VL - 21 IS - 5 N2 - We have studied the diagnostic value for deep venous thrombosis (DVT) of an enzyme immunoassay (EIA) for the detection of D-dimer in plasma of 239 consecutive outpatients suspected of having DVT by their general practitioner. DVT was confirmed by impedance plethysmography in 60 patients. Using the 95th percentile range of 42 healthy volunteers, the sensitivity for the detection of DVT was 92%, with a specificity of 21%. In our population with a prevalence of 25%, the D-dimer EIA showed a negative predictive value of 88% and a positive predictive value of 28%. We conclude that this D-dimer ELISA has limited value, either to confirm or to exclude DVT in outpatients. SN - 0301-0147 UR - https://www.unboundmedicine.com/medline/citation/1806457/Diagnostic_value_of_D_dimer_for_deep_venous_thrombosis_in_outpatients_ DB - PRIME DP - Unbound Medicine ER -