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Ethanol state-dependent memory: involvement of dorsal hippocampal muscarinic and nicotinic receptors.
Neurobiol Learn Mem. 2008 May; 89(4):441-7.NL

Abstract

In the present study, the effects of bilateral injections of cholinergic agents into the hippocampal CA1 regions (intra-CA1) on ethanol state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intraperitoneal injection (i.p.) of ethanol (0.25, 0.5 and 1g/kg) dose dependently induced impairment of memory retention. Pre-test administration of ethanol (0.5 and 1 g/kg, i.p.) induced state-dependent retrieval of the memory acquired under pre-training ethanol (1 g/kg, i.p.) influence. Pre-test intra-CA1 injection of physostigmine (2.5 and 5 microg/mouse, intra-CA1) or nicotine (0.3 and 0.5 microg/mouse, intra-CA1) improved pre-training ethanol (1g/kg)-induced retrieval impairment. Moreover, pre-test administration of physostigmine (2.5 and 5 microg/mouse, intra-CA1) or nicotine (0.3 and 0.5 microg/mouse, intra-CA1) with an ineffective dose of ethanol (0.25 g/kg) significantly restored the retrieval and induced ethanol state-dependent memory. Pre-test intra-CA1 injection of the muscarinic receptor antagonist, atropine (4 and 8 microg/mouse, intra-CA1) or the nicotinic receptor antagonist, mecamylamine (2 and 4 microg/mouse, intra-CA1) 5 min before the administration of ethanol (1g/kg, i.p.) dose dependently inhibited ethanol state-dependent memory. Pre-test intra-CA1 administration of physostigmine (0.5, 2.5 and 5 microg/mouse), atropine (2, 4 and 8 microg/mouse), nicotine (0.1, 0.3 and 0.5 microg/mouse) or mecamylamine (1, 2 and 4 microg/mouse) alone cannot affect memory retention. These findings implicate the involvement of a dorsal hippocampal cholinergic mechanism in ethanol state-dependent memory and also it can be concluded that there may be a cross-state dependency between ethanol and acetylcholine.

Authors+Show Affiliations

Department of Animal Biology, School of Biology, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran. rezayof@khayam.ut.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18065245

Citation

Rezayof, Ameneh, et al. "Ethanol State-dependent Memory: Involvement of Dorsal Hippocampal Muscarinic and Nicotinic Receptors." Neurobiology of Learning and Memory, vol. 89, no. 4, 2008, pp. 441-7.
Rezayof A, Alijanpour S, Zarrindast MR, et al. Ethanol state-dependent memory: involvement of dorsal hippocampal muscarinic and nicotinic receptors. Neurobiol Learn Mem. 2008;89(4):441-7.
Rezayof, A., Alijanpour, S., Zarrindast, M. R., & Rassouli, Y. (2008). Ethanol state-dependent memory: involvement of dorsal hippocampal muscarinic and nicotinic receptors. Neurobiology of Learning and Memory, 89(4), 441-7.
Rezayof A, et al. Ethanol State-dependent Memory: Involvement of Dorsal Hippocampal Muscarinic and Nicotinic Receptors. Neurobiol Learn Mem. 2008;89(4):441-7. PubMed PMID: 18065245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethanol state-dependent memory: involvement of dorsal hippocampal muscarinic and nicotinic receptors. AU - Rezayof,Ameneh, AU - Alijanpour,Sakineh, AU - Zarrindast,Mohammad-Reza, AU - Rassouli,Yassaman, Y1 - 2007/12/11/ PY - 2007/06/10/received PY - 2007/10/14/revised PY - 2007/10/31/accepted PY - 2007/12/11/pubmed PY - 2008/7/17/medline PY - 2007/12/11/entrez SP - 441 EP - 7 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 89 IS - 4 N2 - In the present study, the effects of bilateral injections of cholinergic agents into the hippocampal CA1 regions (intra-CA1) on ethanol state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intraperitoneal injection (i.p.) of ethanol (0.25, 0.5 and 1g/kg) dose dependently induced impairment of memory retention. Pre-test administration of ethanol (0.5 and 1 g/kg, i.p.) induced state-dependent retrieval of the memory acquired under pre-training ethanol (1 g/kg, i.p.) influence. Pre-test intra-CA1 injection of physostigmine (2.5 and 5 microg/mouse, intra-CA1) or nicotine (0.3 and 0.5 microg/mouse, intra-CA1) improved pre-training ethanol (1g/kg)-induced retrieval impairment. Moreover, pre-test administration of physostigmine (2.5 and 5 microg/mouse, intra-CA1) or nicotine (0.3 and 0.5 microg/mouse, intra-CA1) with an ineffective dose of ethanol (0.25 g/kg) significantly restored the retrieval and induced ethanol state-dependent memory. Pre-test intra-CA1 injection of the muscarinic receptor antagonist, atropine (4 and 8 microg/mouse, intra-CA1) or the nicotinic receptor antagonist, mecamylamine (2 and 4 microg/mouse, intra-CA1) 5 min before the administration of ethanol (1g/kg, i.p.) dose dependently inhibited ethanol state-dependent memory. Pre-test intra-CA1 administration of physostigmine (0.5, 2.5 and 5 microg/mouse), atropine (2, 4 and 8 microg/mouse), nicotine (0.1, 0.3 and 0.5 microg/mouse) or mecamylamine (1, 2 and 4 microg/mouse) alone cannot affect memory retention. These findings implicate the involvement of a dorsal hippocampal cholinergic mechanism in ethanol state-dependent memory and also it can be concluded that there may be a cross-state dependency between ethanol and acetylcholine. SN - 1095-9564 UR - https://www.unboundmedicine.com/medline/citation/18065245/Ethanol_state_dependent_memory:_involvement_of_dorsal_hippocampal_muscarinic_and_nicotinic_receptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(07)00175-X DB - PRIME DP - Unbound Medicine ER -