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Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states.
Am J Clin Nutr. 2007 Dec; 86(6):1611-20.AJ

Abstract

BACKGROUND

In subjects with a high prevalence of metabolic risk abnormalities, the preferred replacement for saturated fat is unresolved.

OBJECTIVE

The objective was to study whether carbohydrate or monounsaturated fat is a preferred replacement for saturated fat.

DESIGN

Fifty-two men and 33 women, selected to have any combination of HDL cholesterol < or = 30th percentile, triacylglycerol > or = 70th percentile, or insulin > or = 70th percentile, were enrolled in a 3-period, 7-wk randomized crossover study. The subjects consumed an average American diet (AAD; 36% of energy from fat) and 2 additional diets in which 7% of energy from saturated fat was replaced with either carbohydrate (CHO diet) or monounsaturated fatty acids (MUFA diet).

RESULTS

Relative to the AAD, LDL cholesterol was lower with both the CHO (-7.0%) and MUFA (-6.3%) diets, whereas the difference in HDL cholesterol was smaller during the MUFA diet (-4.3%) than during the CHO diet (-7.2%). Plasma triacylglycerols tended to be lower with the MUFA diet, but were significantly higher with the CHO diet. Although dietary lipid responses varied on the basis of baseline lipid profiles, the response to diet did not differ between subjects with or without the metabolic syndrome or with or without insulin resistance. Postprandial triacylglycerol concentrations did not differ significantly between the diets. Lipoprotein(a) concentrations increased with both the CHO (20%) and MUFA (11%) diets relative to the AAD.

CONCLUSIONS

In the study population, who were at increased risk of coronary artery disease, MUFA provided a greater reduction in risk as a replacement for saturated fat than did carbohydrate.

Authors+Show Affiliations

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA. lars.berglund@ucdmc.ucdavis.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18065577

Citation

Berglund, Lars, et al. "Comparison of Monounsaturated Fat With Carbohydrates as a Replacement for Saturated Fat in Subjects With a High Metabolic Risk Profile: Studies in the Fasting and Postprandial States." The American Journal of Clinical Nutrition, vol. 86, no. 6, 2007, pp. 1611-20.
Berglund L, Lefevre M, Ginsberg HN, et al. Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states. Am J Clin Nutr. 2007;86(6):1611-20.
Berglund, L., Lefevre, M., Ginsberg, H. N., Kris-Etherton, P. M., Elmer, P. J., Stewart, P. W., Ershow, A., Pearson, T. A., Dennis, B. H., Roheim, P. S., Ramakrishnan, R., Reed, R., Stewart, K., & Phillips, K. M. (2007). Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states. The American Journal of Clinical Nutrition, 86(6), 1611-20.
Berglund L, et al. Comparison of Monounsaturated Fat With Carbohydrates as a Replacement for Saturated Fat in Subjects With a High Metabolic Risk Profile: Studies in the Fasting and Postprandial States. Am J Clin Nutr. 2007;86(6):1611-20. PubMed PMID: 18065577.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states. AU - Berglund,Lars, AU - Lefevre,Michael, AU - Ginsberg,Henry N, AU - Kris-Etherton,Penny M, AU - Elmer,Patricia J, AU - Stewart,Paul W, AU - Ershow,Abby, AU - Pearson,Thomas A, AU - Dennis,Barbara H, AU - Roheim,Paul S, AU - Ramakrishnan,Rajasekhar, AU - Reed,Roberta, AU - Stewart,Kent, AU - Phillips,Katherine M, AU - ,, PY - 2007/12/11/pubmed PY - 2008/1/23/medline PY - 2007/12/11/entrez SP - 1611 EP - 20 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 86 IS - 6 N2 - BACKGROUND: In subjects with a high prevalence of metabolic risk abnormalities, the preferred replacement for saturated fat is unresolved. OBJECTIVE: The objective was to study whether carbohydrate or monounsaturated fat is a preferred replacement for saturated fat. DESIGN: Fifty-two men and 33 women, selected to have any combination of HDL cholesterol < or = 30th percentile, triacylglycerol > or = 70th percentile, or insulin > or = 70th percentile, were enrolled in a 3-period, 7-wk randomized crossover study. The subjects consumed an average American diet (AAD; 36% of energy from fat) and 2 additional diets in which 7% of energy from saturated fat was replaced with either carbohydrate (CHO diet) or monounsaturated fatty acids (MUFA diet). RESULTS: Relative to the AAD, LDL cholesterol was lower with both the CHO (-7.0%) and MUFA (-6.3%) diets, whereas the difference in HDL cholesterol was smaller during the MUFA diet (-4.3%) than during the CHO diet (-7.2%). Plasma triacylglycerols tended to be lower with the MUFA diet, but were significantly higher with the CHO diet. Although dietary lipid responses varied on the basis of baseline lipid profiles, the response to diet did not differ between subjects with or without the metabolic syndrome or with or without insulin resistance. Postprandial triacylglycerol concentrations did not differ significantly between the diets. Lipoprotein(a) concentrations increased with both the CHO (20%) and MUFA (11%) diets relative to the AAD. CONCLUSIONS: In the study population, who were at increased risk of coronary artery disease, MUFA provided a greater reduction in risk as a replacement for saturated fat than did carbohydrate. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/18065577/Comparison_of_monounsaturated_fat_with_carbohydrates_as_a_replacement_for_saturated_fat_in_subjects_with_a_high_metabolic_risk_profile:_studies_in_the_fasting_and_postprandial_states_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/86.5.1611 DB - PRIME DP - Unbound Medicine ER -