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Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids.
Am J Clin Nutr. 2007 Dec; 86(6):1621-5.AJ

Abstract

BACKGROUND

n-3 Fatty acids (FAs) have been shown to be beneficial for cardiovascular health. Whether n-3 FAs from oily fish consumed weekly or from fish-oil capsules taken daily are equally bioavailable is not clear.

OBJECTIVE

The purpose of this study was to compare the rate and extent of enrichment of blood cell membranes [ie, red blood cells (RBCs)] and plasma phospholipids with n-3 FAs from these 2 sources.

DESIGN

Healthy premenopausal female volunteers were randomly assigned to consume a daily average of 485 mg eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids either from 2 servings of oily fish (ie, salmon and albacore tuna) per week or from 1-2 capsules/d.

RESULTS

After 16 wk, EPA+DHA in RBCs in the fish group (n = 11) increased from 4.0 +/- 0.6% of total FAs to 6.2 +/- 1.4%, whereas it rose from 4.3 +/- 1.0% to 6.2 +/- 1.4% in the capsule group (P < 0.0001 for both; NS for group effect). Similar results were observed in plasma phospholipids. EPA+DHA stabilized in the latter after 4 wk but continued to rise through week 16 in RBCs. EPA in RBCs increased significantly (P = 0.01) more rapidly in the fish group than in the capsule group during the first 4 wk, but rates did not differ significantly between groups thereafter. Total FA variances were less in RBCs than in plasma phospholipids (P = 0.04).

CONCLUSION

These findings suggest that the consumption of equal amounts of EPA and DHA from oily fish on a weekly basis or from fish-oil capsules on a daily basis is equally effective at enriching blood lipids with n-3 FAs.

Authors+Show Affiliations

Lipid and Diabetes Research Center, Saint Luke's Mid America Heart Institute, Kansas City, MO, USA. bill.harris@usd.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18065578

Citation

Harris, William S., et al. "Comparison of the Effects of Fish and Fish-oil Capsules On the N 3 Fatty Acid Content of Blood Cells and Plasma Phospholipids." The American Journal of Clinical Nutrition, vol. 86, no. 6, 2007, pp. 1621-5.
Harris WS, Pottala JV, Sands SA, et al. Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids. Am J Clin Nutr. 2007;86(6):1621-5.
Harris, W. S., Pottala, J. V., Sands, S. A., & Jones, P. G. (2007). Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids. The American Journal of Clinical Nutrition, 86(6), 1621-5.
Harris WS, et al. Comparison of the Effects of Fish and Fish-oil Capsules On the N 3 Fatty Acid Content of Blood Cells and Plasma Phospholipids. Am J Clin Nutr. 2007;86(6):1621-5. PubMed PMID: 18065578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the effects of fish and fish-oil capsules on the n 3 fatty acid content of blood cells and plasma phospholipids. AU - Harris,William S, AU - Pottala,James V, AU - Sands,Scott A, AU - Jones,Philip G, PY - 2007/12/11/pubmed PY - 2008/1/23/medline PY - 2007/12/11/entrez SP - 1621 EP - 5 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 86 IS - 6 N2 - BACKGROUND: n-3 Fatty acids (FAs) have been shown to be beneficial for cardiovascular health. Whether n-3 FAs from oily fish consumed weekly or from fish-oil capsules taken daily are equally bioavailable is not clear. OBJECTIVE: The purpose of this study was to compare the rate and extent of enrichment of blood cell membranes [ie, red blood cells (RBCs)] and plasma phospholipids with n-3 FAs from these 2 sources. DESIGN: Healthy premenopausal female volunteers were randomly assigned to consume a daily average of 485 mg eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids either from 2 servings of oily fish (ie, salmon and albacore tuna) per week or from 1-2 capsules/d. RESULTS: After 16 wk, EPA+DHA in RBCs in the fish group (n = 11) increased from 4.0 +/- 0.6% of total FAs to 6.2 +/- 1.4%, whereas it rose from 4.3 +/- 1.0% to 6.2 +/- 1.4% in the capsule group (P < 0.0001 for both; NS for group effect). Similar results were observed in plasma phospholipids. EPA+DHA stabilized in the latter after 4 wk but continued to rise through week 16 in RBCs. EPA in RBCs increased significantly (P = 0.01) more rapidly in the fish group than in the capsule group during the first 4 wk, but rates did not differ significantly between groups thereafter. Total FA variances were less in RBCs than in plasma phospholipids (P = 0.04). CONCLUSION: These findings suggest that the consumption of equal amounts of EPA and DHA from oily fish on a weekly basis or from fish-oil capsules on a daily basis is equally effective at enriching blood lipids with n-3 FAs. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/18065578/Comparison_of_the_effects_of_fish_and_fish_oil_capsules_on_the_n_3_fatty_acid_content_of_blood_cells_and_plasma_phospholipids_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/86.5.1621 DB - PRIME DP - Unbound Medicine ER -